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The map label for this gene is lpxK

Identifier: 91788809

GI number: 91788809

Start: 3110797

End: 3111813

Strand: Direct

Name: lpxK

Synonym: Bpro_2949

Alternate gene names: 91788809

Gene position: 3110797-3111813 (Clockwise)

Preceding gene: 91788808

Following gene: 91788810

Centisome position: 59.82

GC content: 63.52

Gene sequence:

>1017_bases
TTGAGGACCTGGCTCACACGGGGTTGGCTGGCTCGTCTGCTGTGGCCGCTGGCGCAACTCCACGGCCAGGCCGTACGCCT
GCGCCGCGCCTTGTACCGCAGCGGCATTCTCGAATCCTGTCGTTTTGGGGTTCCCGTGATCGTGGCCGGCAATGTCGTGG
CCGGTGGTGCAGGCAAGACGCCACTGGTGATGGCGCTGGTCCGGCATTTGCAGGCACAAGGCCTGCAAGTCGGCGTGGTG
TCGCGCGGCTACGGACGGTCCAGCCATGAAAGTCTTGAGGTGAGCATCGGAACACCAGTGGCCCAGTCGGGTGATGAACC
GGCCCTTATAAAGCGCGCAACCAATGCGCCTGTTTTTGTCGCCAAAAAAAGAGCGGATGCCGTGCGCCGGCTGCTGGCGA
CATACCCCTCCACGGCCGTCGTGGTGTGCGACGACGGCTTGCAGCACTACGCCCTTCAGCGAGATATTGAAATTGCCGTG
TTTGACGACCGGGGCGTGGGCAACGGCTGGTTGCTGCCGGCTGGCCCACTGCGCGAACCGTGGCCAGGGCGCAGGCAGCA
AGGCCTTGACCTGGTGCTGCACACCGGCCTGAAGCCGGCTTTTGAAGGCTTCACCTCCGGCCGGCAACTCGCCGACCATG
CCATCGCTGCCGATGGCAGCCAGATCGCGTTAACCGCGCTGCGGGGCCGCACCTTGGTGGCACTGGCCGGCATTGCCAAT
CCCGAAGCCTTCTTTGCCATGCTCAGGGCACGCGGCCTGGTGCTGGAGCAGACCTTGTCCTTGCCGGATCACCACGATTT
TGGCGCCGGCGATCTCGCGGCCTGCGCAGGCAAGACCGTGCTGTGCACCGAAAAAGATGCCGTCAAGCTGTTTGGCAAGC
CGGGCCTCGCCTCCTTGCAGCTTCTGGCCGTTCCCCTGGTGTTTTCGCCCGAACCGGCTTTTTTTGCGGCGCTTGATGCA
CTCCTGGCGCCTCTGCTTTCTCAATTACCATCAGGCCATGGATACCAAACTGCTTGA

Upstream 100 bases:

>100_bases
CGCCATGGCCGGCGCGAAATAGATTTCCGGGCTCTTGCCGGCTCTTCCTTAACCGGCTCTTCCTTAACAACATGGCGAGA
AACGCGTGAAAAACCTCCTG

Downstream 100 bases:

>100_bases
ATTGCTGGTCTGCCCCGTGACGAAGGGCCCGCTGGTCTACGACCGTGAAAAACAGGAACTCATCTCCCGCAGCGCACGGC
TGGCCTACCCGGTACGCGAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRTWLTRGWLARLLWPLAQLHGQAVRLRRALYRSGILESCRFGVPVIVAGNVVAGGAGKTPLVMALVRHLQAQGLQVGVV
SRGYGRSSHESLEVSIGTPVAQSGDEPALIKRATNAPVFVAKKRADAVRRLLATYPSTAVVVCDDGLQHYALQRDIEIAV
FDDRGVGNGWLLPAGPLREPWPGRRQQGLDLVLHTGLKPAFEGFTSGRQLADHAIAADGSQIALTALRGRTLVALAGIAN
PEAFFAMLRARGLVLEQTLSLPDHHDFGAGDLAACAGKTVLCTEKDAVKLFGKPGLASLQLLAVPLVFSPEPAFFAALDA
LLAPLLSQLPSGHGYQTA

Sequences:

>Translated_338_residues
MRTWLTRGWLARLLWPLAQLHGQAVRLRRALYRSGILESCRFGVPVIVAGNVVAGGAGKTPLVMALVRHLQAQGLQVGVV
SRGYGRSSHESLEVSIGTPVAQSGDEPALIKRATNAPVFVAKKRADAVRRLLATYPSTAVVVCDDGLQHYALQRDIEIAV
FDDRGVGNGWLLPAGPLREPWPGRRQQGLDLVLHTGLKPAFEGFTSGRQLADHAIAADGSQIALTALRGRTLVALAGIAN
PEAFFAMLRARGLVLEQTLSLPDHHDFGAGDLAACAGKTVLCTEKDAVKLFGKPGLASLQLLAVPLVFSPEPAFFAALDA
LLAPLLSQLPSGHGYQTA
>Mature_338_residues
MRTWLTRGWLARLLWPLAQLHGQAVRLRRALYRSGILESCRFGVPVIVAGNVVAGGAGKTPLVMALVRHLQAQGLQVGVV
SRGYGRSSHESLEVSIGTPVAQSGDEPALIKRATNAPVFVAKKRADAVRRLLATYPSTAVVVCDDGLQHYALQRDIEIAV
FDDRGVGNGWLLPAGPLREPWPGRRQQGLDLVLHTGLKPAFEGFTSGRQLADHAIAADGSQIALTALRGRTLVALAGIAN
PEAFFAMLRARGLVLEQTLSLPDHHDFGAGDLAACAGKTVLCTEKDAVKLFGKPGLASLQLLAVPLVFSPEPAFFAALDA
LLAPLLSQLPSGHGYQTA

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=338, Percent_Identity=40.5325443786982, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_POLSJ (Q129C9)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_549761.1
- STRING:   Q129C9
- GeneID:   4014368
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_2949
- NMPDR:   fig|296591.1.peg.5539
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- PhylomeDB:   Q129C9
- ProtClustDB:   PRK00652
- BioCyc:   PSP296591:BPRO_2949-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35925; Mature: 35925

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTWLTRGWLARLLWPLAQLHGQAVRLRRALYRSGILESCRFGVPVIVAGNVVAGGAGKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCC
PLVMALVRHLQAQGLQVGVVSRGYGRSSHESLEVSIGTPVAQSGDEPALIKRATNAPVFV
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHEEECCCCCEEE
AKKRADAVRRLLATYPSTAVVVCDDGLQHYALQRDIEIAVFDDRGVGNGWLLPAGPLREP
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCC
WPGRRQQGLDLVLHTGLKPAFEGFTSGRQLADHAIAADGSQIALTALRGRTLVALAGIAN
CCCCHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCC
PEAFFAMLRARGLVLEQTLSLPDHHDFGAGDLAACAGKTVLCTEKDAVKLFGKPGLASLQ
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCHHHHCCCCCCHHHEE
LLAVPLVFSPEPAFFAALDALLAPLLSQLPSGHGYQTA
EEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRTWLTRGWLARLLWPLAQLHGQAVRLRRALYRSGILESCRFGVPVIVAGNVVAGGAGKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCC
PLVMALVRHLQAQGLQVGVVSRGYGRSSHESLEVSIGTPVAQSGDEPALIKRATNAPVFV
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHEEECCCCCEEE
AKKRADAVRRLLATYPSTAVVVCDDGLQHYALQRDIEIAVFDDRGVGNGWLLPAGPLREP
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCC
WPGRRQQGLDLVLHTGLKPAFEGFTSGRQLADHAIAADGSQIALTALRGRTLVALAGIAN
CCCCHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCC
PEAFFAMLRARGLVLEQTLSLPDHHDFGAGDLAACAGKTVLCTEKDAVKLFGKPGLASLQ
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCHHHHCCCCCCHHHEE
LLAVPLVFSPEPAFFAALDALLAPLLSQLPSGHGYQTA
EEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA