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The map label for this gene is gabT [H]

Identifier: 91788772

GI number: 91788772

Start: 3074259

End: 3075551

Strand: Direct

Name: gabT [H]

Synonym: Bpro_2912

Alternate gene names: 91788772

Gene position: 3074259-3075551 (Clockwise)

Preceding gene: 91788769

Following gene: 91788773

Centisome position: 59.12

GC content: 62.1

Gene sequence:

>1293_bases
ATGCCGTCAAATCAACCTACCACCAACGCCGCCCTCATGGCTCGCCGGAAAGCCGCCGTCGCACGCGGCGTCGGCCAGAC
GCATGAGATTTTTGTCAGCCGGGCACGCAACGCCGAGTTCTGGGACGTTGAAGACCGCCGCTACATCGACTTTGCCGGCG
GTATCGCCGTCCTCAACACCGGCCACCTCCATCCGCAAGTGATTGCCGCCGTCAAAACCCAGCTTGACCTTTACACACAC
ACCTGCTTTCAGGTCGTCGCCTATGAGCCCTACGTCGAACTGTCGGAAAAGCTCAACGCGCTGGCGCCCGGCAACTTTGC
CAAGAAAACCCTGCTCCTGAGCACCGGCGCCGAAGCGGTCGAAAACGCCGTGAAGGTGGCCCGCGCCTACACGAAACGTC
CGGGAATCATCGCCTTTACAGGCGGCTACCACGGCAGGACCAACATGACGCTGGGCATGACCGGCAAAGTGGCGCCCTAC
AAGCTGGGTTTTGGCCCGTTCCCGGGGGAAGTTTTCCATGCCCTGTATCCCAACGTGCTGCACGGCGTGAGTGTGGACCA
GGCGCTGCACTCCGTCGAACTGATCCTTAAAAACGACATTGAAGCCGAACGCGTGGCCGCCTTCATCCTCGAGCCCGTAC
AAGGCGAGGGTGGGTTTTACATTGCACCGCCGGAATTCATCACCGGCCTGAAGGCACTGGCAGACCGTCACGGCATCCTG
CTGATTGCCGACGAGGTGCAAACCGGTGCAGGCCGCACTGGAACCTGGTTTGCCAGCGAACAATGGCCTGTGGCTCCGGA
CCTGATCACGACGGCCAAGTCGATGGCGGGCGGCTTCCCCATCTCCGGCCTGGTCGGTCGCGCGGACGTCATGGATGCGC
CGGCCCCCGGTGGGTTGGGAGGTACCTATGCGGGAAGCCCCATCGGCTGCGCCGCAGCACTGGCCGTACTCAAGGTTTTC
GAGGACGAAAAACTCCTCGAACGCAGCAAGGCTCTGGGCGCCCATCTGCTCAAAGGTTTGCGCGCCATCGCGGAGAAAGA
AGTGACCATTGGCGACGTGCGGGGCCTGGGTGCCATGGTGGCGATGGAGCTGTTTGAAAACGGAGATGTCGCCCGCCCCA
ACGCCGCATTGACGCAACGCGTGGTCGCCGAAGCAGCGCGGCGCGGGCTGATCCTGCTGTCGTGCGGCACCTACGGCAAT
GTGATCCGGATTCTGGTTCCCCTCACGGCAAACGACGCCTTGCTAGACGAAGGCCTGAAAATTCTGGCAGACAGCTTTTC
CGCATTGCGCTAA

Upstream 100 bases:

>100_bases
GCACAGTGTGTTGAAAACACCGCAAAGCTGTACATGGACGGGCCTTGAACTGACTTCTACAGTCCAGACGTCCCACCACC
AAATTCATTTTTTCACCACC

Downstream 100 bases:

>100_bases
TGTGCATGACCAGCGTGTATGACCAGCCCGGGAACGACGATGACTAAAAACGATTTCCTTGTACGCTTTTCAAGCGTGCA
AAAAACCTATGACGGCGAGC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPSNQPTTNAALMARRKAAVARGVGQTHEIFVSRARNAEFWDVEDRRYIDFAGGIAVLNTGHLHPQVIAAVKTQLDLYTH
TCFQVVAYEPYVELSEKLNALAPGNFAKKTLLLSTGAEAVENAVKVARAYTKRPGIIAFTGGYHGRTNMTLGMTGKVAPY
KLGFGPFPGEVFHALYPNVLHGVSVDQALHSVELILKNDIEAERVAAFILEPVQGEGGFYIAPPEFITGLKALADRHGIL
LIADEVQTGAGRTGTWFASEQWPVAPDLITTAKSMAGGFPISGLVGRADVMDAPAPGGLGGTYAGSPIGCAAALAVLKVF
EDEKLLERSKALGAHLLKGLRAIAEKEVTIGDVRGLGAMVAMELFENGDVARPNAALTQRVVAEAARRGLILLSCGTYGN
VIRILVPLTANDALLDEGLKILADSFSALR

Sequences:

>Translated_430_residues
MPSNQPTTNAALMARRKAAVARGVGQTHEIFVSRARNAEFWDVEDRRYIDFAGGIAVLNTGHLHPQVIAAVKTQLDLYTH
TCFQVVAYEPYVELSEKLNALAPGNFAKKTLLLSTGAEAVENAVKVARAYTKRPGIIAFTGGYHGRTNMTLGMTGKVAPY
KLGFGPFPGEVFHALYPNVLHGVSVDQALHSVELILKNDIEAERVAAFILEPVQGEGGFYIAPPEFITGLKALADRHGIL
LIADEVQTGAGRTGTWFASEQWPVAPDLITTAKSMAGGFPISGLVGRADVMDAPAPGGLGGTYAGSPIGCAAALAVLKVF
EDEKLLERSKALGAHLLKGLRAIAEKEVTIGDVRGLGAMVAMELFENGDVARPNAALTQRVVAEAARRGLILLSCGTYGN
VIRILVPLTANDALLDEGLKILADSFSALR
>Mature_429_residues
PSNQPTTNAALMARRKAAVARGVGQTHEIFVSRARNAEFWDVEDRRYIDFAGGIAVLNTGHLHPQVIAAVKTQLDLYTHT
CFQVVAYEPYVELSEKLNALAPGNFAKKTLLLSTGAEAVENAVKVARAYTKRPGIIAFTGGYHGRTNMTLGMTGKVAPYK
LGFGPFPGEVFHALYPNVLHGVSVDQALHSVELILKNDIEAERVAAFILEPVQGEGGFYIAPPEFITGLKALADRHGILL
IADEVQTGAGRTGTWFASEQWPVAPDLITTAKSMAGGFPISGLVGRADVMDAPAPGGLGGTYAGSPIGCAAALAVLKVFE
DEKLLERSKALGAHLLKGLRAIAEKEVTIGDVRGLGAMVAMELFENGDVARPNAALTQRVVAEAARRGLILLSCGTYGNV
IRILVPLTANDALLDEGLKILADSFSALR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=403, Percent_Identity=33.4987593052109, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI13994255, Length=420, Percent_Identity=30, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=27.8846153846154, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=33.4375, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=28.3116883116883, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442705, Length=415, Percent_Identity=27.4698795180723, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=24.6543778801843, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI188536080, Length=425, Percent_Identity=26.5882352941176, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI38679950, Length=425, Percent_Identity=26.5882352941176, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI38679946, Length=425, Percent_Identity=26.5882352941176, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=63.895486935867, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=55.4761904761905, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=34.3283582089552, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=34.6633416458853, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI145693181, Length=399, Percent_Identity=31.328320802005, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786349, Length=340, Percent_Identity=33.5294117647059, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786991, Length=348, Percent_Identity=31.0344827586207, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=30.6264501160093, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=434, Percent_Identity=30.6451612903226, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=30.2211302211302, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=32.183908045977, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=26.4501160092807, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=31.5789473684211, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=415, Percent_Identity=30.3614457831325, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=371, Percent_Identity=22.3719676549865, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=25.1366120218579, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574759, Length=399, Percent_Identity=31.328320802005, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI161085790, Length=417, Percent_Identity=30.4556354916067, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21357415, Length=444, Percent_Identity=30.1801801801802, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=28.5714285714286, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=28.2967032967033, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=28.2967032967033, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=28.2967032967033, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45663; Mature: 45532

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSNQPTTNAALMARRKAAVARGVGQTHEIFVSRARNAEFWDVEDRRYIDFAGGIAVLNT
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCEEEEECCCEEEEEC
GHLHPQVIAAVKTQLDLYTHTCFQVVAYEPYVELSEKLNALAPGNFAKKTLLLSTGAEAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHEEEEECCHHHH
ENAVKVARAYTKRPGIIAFTGGYHGRTNMTLGMTGKVAPYKLGFGPFPGEVFHALYPNVL
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCEECCCCCCCHHHHHHHHHHHH
HGVSVDQALHSVELILKNDIEAERVAAFILEPVQGEGGFYIAPPEFITGLKALADRHGIL
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCCEE
LIADEVQTGAGRTGTWFASEQWPVAPDLITTAKSMAGGFPISGLVGRADVMDAPAPGGLG
EEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GTYAGSPIGCAAALAVLKVFEDEKLLERSKALGAHLLKGLRAIAEKEVTIGDVRGLGAMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMELFENGDVARPNAALTQRVVAEAARRGLILLSCGTYGNVIRILVPLTANDALLDEGLK
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHH
ILADSFSALR
HHHHHHHHCC
>Mature Secondary Structure 
PSNQPTTNAALMARRKAAVARGVGQTHEIFVSRARNAEFWDVEDRRYIDFAGGIAVLNT
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCEEEEECCCEEEEEC
GHLHPQVIAAVKTQLDLYTHTCFQVVAYEPYVELSEKLNALAPGNFAKKTLLLSTGAEAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHEEEEECCHHHH
ENAVKVARAYTKRPGIIAFTGGYHGRTNMTLGMTGKVAPYKLGFGPFPGEVFHALYPNVL
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCEECCCCCCCHHHHHHHHHHHH
HGVSVDQALHSVELILKNDIEAERVAAFILEPVQGEGGFYIAPPEFITGLKALADRHGIL
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCCEE
LIADEVQTGAGRTGTWFASEQWPVAPDLITTAKSMAGGFPISGLVGRADVMDAPAPGGLG
EEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GTYAGSPIGCAAALAVLKVFEDEKLLERSKALGAHLLKGLRAIAEKEVTIGDVRGLGAMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMELFENGDVARPNAALTQRVVAEAARRGLILLSCGTYGNVIRILVPLTANDALLDEGLK
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHH
ILADSFSALR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]