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The map label for this gene is hmuU [H]

Identifier: 91788643

GI number: 91788643

Start: 2922237

End: 2923271

Strand: Reverse

Name: hmuU [H]

Synonym: Bpro_2781

Alternate gene names: 91788643

Gene position: 2923271-2922237 (Counterclockwise)

Preceding gene: 91788644

Following gene: 91788642

Centisome position: 56.21

GC content: 67.63

Gene sequence:

>1035_bases
GTGAGGGCGCCGAACCGTTCTTTTGCCGTGCATGACCAGCACCGCAAGGCCTTCTGGCTGGCCGGTGCCTTGCTGGTGGC
CTCCGCAGCGCTATTGCTGCTGGGCGCCAGCGTGGGCAGCATCGGCTTTGAAAGCGTGATGAACATGCAGCACGACACGC
AGGCCATGCAAATCGTCTGGGAGATTCGCCTGCCGCGCACGGCCGGTGCGTGGCTGGCGGGGGCGCTGTTCGGCCTGGCG
GGCGCCGTGGCGCAGGGCCTGTTTCGCAACCCGTTGGCCGACCCGTATTTGCTGGGCAGCGCCTCGGGCGCTTTGCTGGG
TGAGGCGTGTGCGATGGTGCTGCTGGGCGTGTCGCCTCTGGCCGCGCATTGGCTTGTGCGGATTGGGTTGACGGGGGCTG
CCTTTGTCGGCGCCGTGCTTGCCGTGTTGCTGACCCTGGTGCTGGCCAAGGGCGTGCAACACACGCTGCGGCTGCTGCTG
GCCGGTGTGGTCGTGGGGGTGGTGCTGGGCGCCGTCAGCTCGCTCATTTTGCTGCTGAGCCCAAACATCATGCAGGCCAT
GCAGTCTTTCATGTTGGGCAGTACGGCGTTTGTGGACTGGACCGCCTGTGCCGTGATGGCCCTGGTGCTGGCAGTCAGCG
TGATTGCTGCCTGGATGATGAGCCATGTGCTGGATGGCCTGGCGCTGGGCGAAGCCACCGCGCAAAGCCTGGGCCTGCAG
CTGCCGCAAATGCGGGCCGCGCTGGTGGCGGTGCTGGCGCTGGCCACCGGCGCGGCAGTGGCGCAAACCGGCCTGATCGC
CTTCGTCGGCCTGGCCGCGCCGCACCTGGTGCGCTCGGTCGTCAAGACGACGCACGGCCGGCTCATTGTGCTGTCCAGCC
TGATGGGCGCGGTGCTGCTGATGGCCGCCGATATTCTGGCGCGCTGGCTGATTGCGCCGCAAGAGTTGCCCGTGGGCGTT
CTCACGGCGGTGCTGGGCGGCGGCTACCTGCTGTGGCTGATGCACCGGCATACCGGAAGAGGGGCAGGATTGTGA

Upstream 100 bases:

>100_bases
GTGTCTTCGGTGTGGACGAATCCGACGTGGTGGTGCGTCCCGGCCCGCGCATGGCCGAGGCGGCGCGCATCATGGCCAAG
TGCCTTGAAGGCAAGCAGCG

Downstream 100 bases:

>100_bases
TGGCTCCTATTGATCCGGTCGCCATGAATTCAATAGCTGTTGGCGCCCATGCCGTCAGGGCTCGCCTCGGAAATGTCGAA
GTGTTGCATGGCATAACGCT

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRAPNRSFAVHDQHRKAFWLAGALLVASAALLLLGASVGSIGFESVMNMQHDTQAMQIVWEIRLPRTAGAWLAGALFGLA
GAVAQGLFRNPLADPYLLGSASGALLGEACAMVLLGVSPLAAHWLVRIGLTGAAFVGAVLAVLLTLVLAKGVQHTLRLLL
AGVVVGVVLGAVSSLILLLSPNIMQAMQSFMLGSTAFVDWTACAVMALVLAVSVIAAWMMSHVLDGLALGEATAQSLGLQ
LPQMRAALVAVLALATGAAVAQTGLIAFVGLAAPHLVRSVVKTTHGRLIVLSSLMGAVLLMAADILARWLIAPQELPVGV
LTAVLGGGYLLWLMHRHTGRGAGL

Sequences:

>Translated_344_residues
MRAPNRSFAVHDQHRKAFWLAGALLVASAALLLLGASVGSIGFESVMNMQHDTQAMQIVWEIRLPRTAGAWLAGALFGLA
GAVAQGLFRNPLADPYLLGSASGALLGEACAMVLLGVSPLAAHWLVRIGLTGAAFVGAVLAVLLTLVLAKGVQHTLRLLL
AGVVVGVVLGAVSSLILLLSPNIMQAMQSFMLGSTAFVDWTACAVMALVLAVSVIAAWMMSHVLDGLALGEATAQSLGLQ
LPQMRAALVAVLALATGAAVAQTGLIAFVGLAAPHLVRSVVKTTHGRLIVLSSLMGAVLLMAADILARWLIAPQELPVGV
LTAVLGGGYLLWLMHRHTGRGAGL
>Mature_344_residues
MRAPNRSFAVHDQHRKAFWLAGALLVASAALLLLGASVGSIGFESVMNMQHDTQAMQIVWEIRLPRTAGAWLAGALFGLA
GAVAQGLFRNPLADPYLLGSASGALLGEACAMVLLGVSPLAAHWLVRIGLTGAAFVGAVLAVLLTLVLAKGVQHTLRLLL
AGVVVGVVLGAVSSLILLLSPNIMQAMQSFMLGSTAFVDWTACAVMALVLAVSVIAAWMMSHVLDGLALGEATAQSLGLQ
LPQMRAALVAVLALATGAAVAQTGLIAFVGLAAPHLVRSVVKTTHGRLIVLSSLMGAVLLMAADILARWLIAPQELPVGV
LTAVLGGGYLLWLMHRHTGRGAGL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=40.0709219858156, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790740, Length=318, Percent_Identity=35.5345911949685, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790741, Length=288, Percent_Identity=31.9444444444444, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=35.8620689655172, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786347, Length=342, Percent_Identity=30.1169590643275, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786804, Length=301, Percent_Identity=32.890365448505, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35461; Mature: 35461

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPNRSFAVHDQHRKAFWLAGALLVASAALLLLGASVGSIGFESVMNMQHDTQAMQIVW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIRLPRTAGAWLAGALFGLAGAVAQGLFRNPLADPYLLGSASGALLGEACAMVLLGVSPL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCHH
AAHWLVRIGLTGAAFVGAVLAVLLTLVLAKGVQHTLRLLLAGVVVGVVLGAVSSLILLLS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNIMQAMQSFMLGSTAFVDWTACAVMALVLAVSVIAAWMMSHVLDGLALGEATAQSLGLQ
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPQMRAALVAVLALATGAAVAQTGLIAFVGLAAPHLVRSVVKTTHGRLIVLSSLMGAVLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
MAADILARWLIAPQELPVGVLTAVLGGGYLLWLMHRHTGRGAGL
HHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRAPNRSFAVHDQHRKAFWLAGALLVASAALLLLGASVGSIGFESVMNMQHDTQAMQIVW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIRLPRTAGAWLAGALFGLAGAVAQGLFRNPLADPYLLGSASGALLGEACAMVLLGVSPL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCHH
AAHWLVRIGLTGAAFVGAVLAVLLTLVLAKGVQHTLRLLLAGVVVGVVLGAVSSLILLLS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNIMQAMQSFMLGSTAFVDWTACAVMALVLAVSVIAAWMMSHVLDGLALGEATAQSLGLQ
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPQMRAALVAVLALATGAAVAQTGLIAFVGLAAPHLVRSVVKTTHGRLIVLSSLMGAVLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
MAADILARWLIAPQELPVGVLTAVLGGGYLLWLMHRHTGRGAGL
HHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]