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The map label for this gene is metC [H]

Identifier: 91788457

GI number: 91788457

Start: 2725134

End: 2726324

Strand: Reverse

Name: metC [H]

Synonym: Bpro_2595

Alternate gene names: 91788457

Gene position: 2726324-2725134 (Counterclockwise)

Preceding gene: 91788458

Following gene: 91788456

Centisome position: 52.43

GC content: 62.55

Gene sequence:

>1191_bases
ATGAGCGATCCATCCACCCAACTAATCCATCACCCTTACACCTCGCCGGCGGGCTTTGAGGCCGTTGCACCGGGGGTGCA
CAAGGCCTCCACGGTGATCTTTCCCAGCGTTGCGGCGCTGCGCAACCGCGACTGGAAACACAAGACGGGCTATACCTACG
GCTTGCACGGTACCCCCACCACCTTCACGCTGGAAGAGCGCATTGCCACCCTGGAGGGCGGCAAGTTCTGCACCCTGGTG
CCCAGCGGCCTGGCTGCCGTGGTGCTGGTGGACATGGCCCTGCTGAAGTCCGGTGATGAAGTGCTGATTCCCGACAATGC
CTATGGGCCCAGCAAGGCATTTGCGCAGGCTGAGCTTGCAGCCTGGGATATCAGTTTTCAGTTTTATGACGCCATGAATC
CGGCCGATCTGGCCGCCAAACTGAACCGCAAAACGCGGCTGGTCTGGCTGGAAGCGCCGGGCTCCATCACGCTGGAGTTC
CCTGACCTTCCGGCGCTGGTGGCCGTCGTCAAGGCGAACAACCAGTCTGACAAGATGGCCCACCCATTGGGCACGGTTAC
CGCGCTGGACAACACCTGGGGCGCAGGCCTGGCGTTCAACGCTTTCTGGCTCGGTGCGGACATCTCCGTGCAGGCCCTCA
CCAAATACCCCAGCGGTGGCGCGGACGTGCTGATGGGTTCAGTGGTCACCAACGATGAAGTCCTGCACCATCTGGTTCAT
TTGTGCCACATGCGCGTCGGCTATGGCGTGAGCGGCAACGATGCCGAACTGGTGTTGCGCGGCTTGAACAGCATGGCCTT
GCGCTACGCCGCACAAGATGCCGCCACGCAACAGCTGGCGGTCTGGTTGCAGGCCCAGCCGCAAATCGCCGCCGTGCTGC
ATCCCGCATTGCCCGGATCGCCCGGACATGACACATGGAAGCGCGATTGCACAGGTGCGGCCTGCCTGCTCAGCGCCGTG
TTCAAGCCCGAGTTCACACAGGAGCGGATCGACCGTTTTTGCGACAGCCTCCAGTTGTTCAAGCTGGGCTACAGCTGGGC
CGGGCCCATGAGCCTGTGCGTGCCTTATGACGTGCCAGCCATGCGTCGCACGCCGTGGTCGCATCGGGGTGGTTTGGTAC
GTTTTTCAATCGGCCTGGAGTCTGTGGCAGACCTGCGGGCAGACCTGGCTCAGGCGCTCCTGATCGCTTGA

Upstream 100 bases:

>100_bases
AAAATTGCGGCCATTTATCGATGTGCAAGCGGCGCTGTTCCCCAAGCTCACGGCCCGGGTACGGCCACCGCCTGTCGGGG
CATGCCGTTAACATCGGCGC

Downstream 100 bases:

>100_bases
TTCGGGCCTGCTGAAGACTTGATGAAGCCCTGACGGCGATGCAGTACAGTAAGGGTTAATCATTCACGAAAGCACGCTGT
GGCAACTCCTAATTATTCCT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSDPSTQLIHHPYTSPAGFEAVAPGVHKASTVIFPSVAALRNRDWKHKTGYTYGLHGTPTTFTLEERIATLEGGKFCTLV
PSGLAAVVLVDMALLKSGDEVLIPDNAYGPSKAFAQAELAAWDISFQFYDAMNPADLAAKLNRKTRLVWLEAPGSITLEF
PDLPALVAVVKANNQSDKMAHPLGTVTALDNTWGAGLAFNAFWLGADISVQALTKYPSGGADVLMGSVVTNDEVLHHLVH
LCHMRVGYGVSGNDAELVLRGLNSMALRYAAQDAATQQLAVWLQAQPQIAAVLHPALPGSPGHDTWKRDCTGAACLLSAV
FKPEFTQERIDRFCDSLQLFKLGYSWAGPMSLCVPYDVPAMRRTPWSHRGGLVRFSIGLESVADLRADLAQALLIA

Sequences:

>Translated_396_residues
MSDPSTQLIHHPYTSPAGFEAVAPGVHKASTVIFPSVAALRNRDWKHKTGYTYGLHGTPTTFTLEERIATLEGGKFCTLV
PSGLAAVVLVDMALLKSGDEVLIPDNAYGPSKAFAQAELAAWDISFQFYDAMNPADLAAKLNRKTRLVWLEAPGSITLEF
PDLPALVAVVKANNQSDKMAHPLGTVTALDNTWGAGLAFNAFWLGADISVQALTKYPSGGADVLMGSVVTNDEVLHHLVH
LCHMRVGYGVSGNDAELVLRGLNSMALRYAAQDAATQQLAVWLQAQPQIAAVLHPALPGSPGHDTWKRDCTGAACLLSAV
FKPEFTQERIDRFCDSLQLFKLGYSWAGPMSLCVPYDVPAMRRTPWSHRGGLVRFSIGLESVADLRADLAQALLIA
>Mature_395_residues
SDPSTQLIHHPYTSPAGFEAVAPGVHKASTVIFPSVAALRNRDWKHKTGYTYGLHGTPTTFTLEERIATLEGGKFCTLVP
SGLAAVVLVDMALLKSGDEVLIPDNAYGPSKAFAQAELAAWDISFQFYDAMNPADLAAKLNRKTRLVWLEAPGSITLEFP
DLPALVAVVKANNQSDKMAHPLGTVTALDNTWGAGLAFNAFWLGADISVQALTKYPSGGADVLMGSVVTNDEVLHHLVHL
CHMRVGYGVSGNDAELVLRGLNSMALRYAAQDAATQQLAVWLQAQPQIAAVLHPALPGSPGHDTWKRDCTGAACLLSAVF
KPEFTQERIDRFCDSLQLFKLGYSWAGPMSLCVPYDVPAMRRTPWSHRGGLVRFSIGLESVADLRADLAQALLIA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=354, Percent_Identity=31.3559322033898, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI299473759, Length=354, Percent_Identity=28.2485875706215, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI25453487, Length=354, Percent_Identity=29.6610169491525, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=36.7609254498715, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=28.9473684210526, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17538055, Length=355, Percent_Identity=33.5211267605634, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=353, Percent_Identity=32.5779036827195, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71980708, Length=378, Percent_Identity=27.7777777777778, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=34.9253731343284, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319307, Length=354, Percent_Identity=29.3785310734463, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323333, Length=437, Percent_Identity=25.1716247139588, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321254, Length=386, Percent_Identity=24.3523316062176, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922554, Length=396, Percent_Identity=30.8080808080808, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42659; Mature: 42528

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSTQLIHHPYTSPAGFEAVAPGVHKASTVIFPSVAALRNRDWKHKTGYTYGLHGTPT
CCCCCCCEEECCCCCCCCCHHHCCCCCCCCEEECCCHHHHHCCCCCCCCCEEEECCCCCC
TFTLEERIATLEGGKFCTLVPSGLAAVVLVDMALLKSGDEVLIPDNAYGPSKAFAQAELA
EEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHE
AWDISFQFYDAMNPADLAAKLNRKTRLVWLEAPGSITLEFPDLPALVAVVKANNQSDKMA
EEEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCEEEEECCCCCEEEEEEECCCCCCHHH
HPLGTVTALDNTWGAGLAFNAFWLGADISVQALTKYPSGGADVLMGSVVTNDEVLHHLVH
CCCCEEEEECCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHEEEEHCCCHHHHHHHHH
LCHMRVGYGVSGNDAELVLRGLNSMALRYAAQDAATQQLAVWLQAQPQIAAVLHPALPGS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCC
PGHDTWKRDCTGAACLLSAVFKPEFTQERIDRFCDSLQLFKLGYSWAGPMSLCVPYDVPA
CCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC
MRRTPWSHRGGLVRFSIGLESVADLRADLAQALLIA
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDPSTQLIHHPYTSPAGFEAVAPGVHKASTVIFPSVAALRNRDWKHKTGYTYGLHGTPT
CCCCCCEEECCCCCCCCCHHHCCCCCCCCEEECCCHHHHHCCCCCCCCCEEEECCCCCC
TFTLEERIATLEGGKFCTLVPSGLAAVVLVDMALLKSGDEVLIPDNAYGPSKAFAQAELA
EEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHE
AWDISFQFYDAMNPADLAAKLNRKTRLVWLEAPGSITLEFPDLPALVAVVKANNQSDKMA
EEEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCEEEEECCCCCEEEEEEECCCCCCHHH
HPLGTVTALDNTWGAGLAFNAFWLGADISVQALTKYPSGGADVLMGSVVTNDEVLHHLVH
CCCCEEEEECCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHEEEEHCCCHHHHHHHHH
LCHMRVGYGVSGNDAELVLRGLNSMALRYAAQDAATQQLAVWLQAQPQIAAVLHPALPGS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCC
PGHDTWKRDCTGAACLLSAVFKPEFTQERIDRFCDSLQLFKLGYSWAGPMSLCVPYDVPA
CCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC
MRRTPWSHRGGLVRFSIGLESVADLRADLAQALLIA
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]