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The map label for this gene is dhlA [H]

Identifier: 91788312

GI number: 91788312

Start: 2549439

End: 2550824

Strand: Direct

Name: dhlA [H]

Synonym: Bpro_2447

Alternate gene names: 91788312

Gene position: 2549439-2550824 (Clockwise)

Preceding gene: 91788311

Following gene: 91788313

Centisome position: 49.03

GC content: 63.56

Gene sequence:

>1386_bases
ATGGACGACGCCTTCTTTATGCAACTCGCGCTGGCGCAGGCCCGTGAAGCCGCAGCGGTGGGGGAGGTACCGGTGGGTGC
TGTCGTGGTGCGACATGGCGAAGTCATTGCCACGGGTCGCAACGCGCCGGTTGACGCGAATGACCCGACGGCCCATGCCG
AGATCGTCGCCCTTCGTGCGGCAGCGCAGGCGCTGGGCAACTACCGGCTGGATGAATGCGAACTGTTTGTCACGCTCGAA
CCCTGCGCCATGTGCAGCGGCGCGATGCTGCACGCCCGGCTCCAGCGCGTGGTGTTCGGCGCGACCGACCCCAAAACCGG
TGCGGCCGGCTCGGTCATCAACCTGTTTGCGGAATCCCGGCTGAACCATCAAACCGGGTGGCAAGGTGGCGTATTGGCGG
AGGAATGCGGCGAGTTGCTGCAGGCGTTTTTTCGCCGGCGCCGGGCCGACAAGCGCGAAAAGTTCCGGCTGAACCATCCG
CTGCGTGACGATGCGCTGCGCACACCCGATGCGGCTTTCGATGATTTGCCGGGCTATCCGTGGCCGCCCCGCTATGTCAG
CGACCTCCCGGCGCTGGACGGGCTGCGCATGCACTACCTTGACGAAGGCGAGGGCGGGCCGGGAGGCCTGACCTATTTGT
GCTTGCACGGCAATCCCGCCTGGAGTTACCTGTACCGGAAAATGATCCCGGTCTTTTTGCAGGCAGGCCACCGGGTGGTC
GCGCCTGACCTGATTGGTTTTGGCAAAAGCGACAAACCCAAGAAGGACAGCTTTCACAGCTTTGGCGTCCATCGCCAGAT
CCTCCTGGAACTGGTGGATCGGCTAGACCTGCAAAACGTCGTGCTCGTCGTACAGGACTGGGGCGGGTTGCTTGGCCTGA
CATTGCCAATGGTTGCTCCGTTGCGCTACAAGGGCCTGCTGGTCATGAACACCATGCTGGCTACCAGTGATGTGCCGTTG
TCACCTGGTTTCAGAGCCTGGCGCGAGATGTGCGCCAAAAACCCGGATTTCGATGTGGCTCGCCTTTTTGCCCGTGGCAA
CCCGCAGATGAGTCCTGATGAATGCGCGGCCTACAACGCCCCGTTCCCGGACAAAGGCCATCGTGCAGCGCTGCGCGCCT
TTCCGCTGATGGTGCCGGAATCTGAATGTGCCGATGGTGCCGCCATCTCCAGGGAGGCGCGCGAGTTTTGGCAGAGCCGC
TGGACAGGGCAGACCCTCATGGCTGTCGGCGCCCAGGACCCGGTATTGGGCCTGCCGGTCATGCGTGCGTTGCAGGGCAT
TATTCGCGGCTGTGACGCCCCTCTCGTGCTGGAGCAGGCCGGGCACTTCGTGCAGGAGCACGGGGAGCCGATTGCCCGGC
ATGCGGTCGGCTTCTTCAAACGGTGA

Upstream 100 bases:

>100_bases
TGCAGCAGGCCCGCCCCATGCCCGATGACGAGTAAGCAGATAAAAAGCACTGCCTTCCCAGGTCGGGCTTGCTCGTAAAG
CTATTAAAATAATAGCAATC

Downstream 100 bases:

>100_bases
CCTGAAACCACGCGTGAATGCTGATCAGCAATGGGATACTCCTGCCTGTGAAAAAACATATCTACATTTACTCGCCTTCC
AGCGCCGTGCGCGACAAAGC

Product: CMP/dCMP deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MDDAFFMQLALAQAREAAAVGEVPVGAVVVRHGEVIATGRNAPVDANDPTAHAEIVALRAAAQALGNYRLDECELFVTLE
PCAMCSGAMLHARLQRVVFGATDPKTGAAGSVINLFAESRLNHQTGWQGGVLAEECGELLQAFFRRRRADKREKFRLNHP
LRDDALRTPDAAFDDLPGYPWPPRYVSDLPALDGLRMHYLDEGEGGPGGLTYLCLHGNPAWSYLYRKMIPVFLQAGHRVV
APDLIGFGKSDKPKKDSFHSFGVHRQILLELVDRLDLQNVVLVVQDWGGLLGLTLPMVAPLRYKGLLVMNTMLATSDVPL
SPGFRAWREMCAKNPDFDVARLFARGNPQMSPDECAAYNAPFPDKGHRAALRAFPLMVPESECADGAAISREAREFWQSR
WTGQTLMAVGAQDPVLGLPVMRALQGIIRGCDAPLVLEQAGHFVQEHGEPIARHAVGFFKR

Sequences:

>Translated_461_residues
MDDAFFMQLALAQAREAAAVGEVPVGAVVVRHGEVIATGRNAPVDANDPTAHAEIVALRAAAQALGNYRLDECELFVTLE
PCAMCSGAMLHARLQRVVFGATDPKTGAAGSVINLFAESRLNHQTGWQGGVLAEECGELLQAFFRRRRADKREKFRLNHP
LRDDALRTPDAAFDDLPGYPWPPRYVSDLPALDGLRMHYLDEGEGGPGGLTYLCLHGNPAWSYLYRKMIPVFLQAGHRVV
APDLIGFGKSDKPKKDSFHSFGVHRQILLELVDRLDLQNVVLVVQDWGGLLGLTLPMVAPLRYKGLLVMNTMLATSDVPL
SPGFRAWREMCAKNPDFDVARLFARGNPQMSPDECAAYNAPFPDKGHRAALRAFPLMVPESECADGAAISREAREFWQSR
WTGQTLMAVGAQDPVLGLPVMRALQGIIRGCDAPLVLEQAGHFVQEHGEPIARHAVGFFKR
>Mature_461_residues
MDDAFFMQLALAQAREAAAVGEVPVGAVVVRHGEVIATGRNAPVDANDPTAHAEIVALRAAAQALGNYRLDECELFVTLE
PCAMCSGAMLHARLQRVVFGATDPKTGAAGSVINLFAESRLNHQTGWQGGVLAEECGELLQAFFRRRRADKREKFRLNHP
LRDDALRTPDAAFDDLPGYPWPPRYVSDLPALDGLRMHYLDEGEGGPGGLTYLCLHGNPAWSYLYRKMIPVFLQAGHRVV
APDLIGFGKSDKPKKDSFHSFGVHRQILLELVDRLDLQNVVLVVQDWGGLLGLTLPMVAPLRYKGLLVMNTMLATSDVPL
SPGFRAWREMCAKNPDFDVARLFARGNPQMSPDECAAYNAPFPDKGHRAALRAFPLMVPESECADGAAISREAREFWQSR
WTGQTLMAVGAQDPVLGLPVMRALQGIIRGCDAPLVLEQAGHFVQEHGEPIARHAVGFFKR

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes terminally mono- and di- c

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=154, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI27597073, Length=149, Percent_Identity=31.5436241610738, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693172, Length=146, Percent_Identity=51.3698630136986, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17554608, Length=106, Percent_Identity=38.6792452830189, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=34.4594594594595, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=98, Percent_Identity=40.8163265306122, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324392, Length=118, Percent_Identity=32.2033898305085, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21355527, Length=148, Percent_Identity=34.4594594594595, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 50575; Mature: 50575

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDAFFMQLALAQAREAAAVGEVPVGAVVVRHGEVIATGRNAPVDANDPTAHAEIVALRA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHH
AAQALGNYRLDECELFVTLEPCAMCSGAMLHARLQRVVFGATDPKTGAAGSVINLFAESR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LNHQTGWQGGVLAEECGELLQAFFRRRRADKREKFRLNHPLRDDALRTPDAAFDDLPGYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHCCCCCCCCHHCCCCCC
WPPRYVSDLPALDGLRMHYLDEGEGGPGGLTYLCLHGNPAWSYLYRKMIPVFLQAGHRVV
CCCHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
APDLIGFGKSDKPKKDSFHSFGVHRQILLELVDRLDLQNVVLVVQDWGGLLGLTLPMVAP
CCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCC
LRYKGLLVMNTMLATSDVPLSPGFRAWREMCAKNPDFDVARLFARGNPQMSPDECAAYNA
HHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHCCCC
PFPDKGHRAALRAFPLMVPESECADGAAISREAREFWQSRWTGQTLMAVGAQDPVLGLPV
CCCCCCCHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
MRALQGIIRGCDAPLVLEQAGHFVQEHGEPIARHAVGFFKR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MDDAFFMQLALAQAREAAAVGEVPVGAVVVRHGEVIATGRNAPVDANDPTAHAEIVALRA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHH
AAQALGNYRLDECELFVTLEPCAMCSGAMLHARLQRVVFGATDPKTGAAGSVINLFAESR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LNHQTGWQGGVLAEECGELLQAFFRRRRADKREKFRLNHPLRDDALRTPDAAFDDLPGYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHCCCCCCCCHHCCCCCC
WPPRYVSDLPALDGLRMHYLDEGEGGPGGLTYLCLHGNPAWSYLYRKMIPVFLQAGHRVV
CCCHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
APDLIGFGKSDKPKKDSFHSFGVHRQILLELVDRLDLQNVVLVVQDWGGLLGLTLPMVAP
CCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCC
LRYKGLLVMNTMLATSDVPLSPGFRAWREMCAKNPDFDVARLFARGNPQMSPDECAAYNA
HHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHCCCC
PFPDKGHRAALRAFPLMVPESECADGAAISREAREFWQSRWTGQTLMAVGAQDPVLGLPV
CCCCCCCHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
MRALQGIIRGCDAPLVLEQAGHFVQEHGEPIARHAVGFFKR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2687254; 4019411; 3398051; 2026135; 8355275; 8515812; 9790663; 10508409; 10393294 [H]