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The map label for this gene is pepA

Identifier: 91788273

GI number: 91788273

Start: 2506491

End: 2508014

Strand: Direct

Name: pepA

Synonym: Bpro_2408

Alternate gene names: 91788273

Gene position: 2506491-2508014 (Clockwise)

Preceding gene: 91788265

Following gene: 91788274

Centisome position: 48.2

GC content: 63.06

Gene sequence:

>1524_bases
ATGGACTTTGAACTCAAACTGCTTCCCCTCGCCCGTATTTGCAGCGAAAAATGCGATGCGCTGCTAGTACTGATACCCCA
GGATTTGAGCGCCGGAGGCGATGACCCCCTGTCCGCACTCGCAGCACTCGCCCTCAAGGCCGGTGACCTGGAGGCCAAGC
CGGGCAAGCTGCTGAGCGCCTACCGTACGCCGGGCATTGCGGCAACGAGGGTGGTGCTGGCGGGTGTAGGCGACGCCAGT
CCCCGAAATGTCCGGACCGCCGTGAATGCAGCGATGGCAAACCTGAAGAACGGCAATACGCAGCGGGTCGTCGTCAGTCT
TGCCGCCATGAACAACGCGCAGCCAGAAATCGTCCGGGCCGCGGTGGTGGCCTGCAGCGAGGCTGCTTACGTTTACAGCA
CCACCAAATCCAAGGTCAGTCCTGTCAAATTGCAGCGGGTGGTGATTGGCGTGAACGAGCTGTCGGTGGCCAGGCCGGGT
TTTGACAAGGCTCTGGCGCTTGTCAAGGGTATTGAATTTGCCAAGGAGTGGGCCAACCGGCCCGCCAACCATGCGACACC
CACCCTGCTGGCGGGGGCGGCCAGGGAACTGGCGAGATTGCGCAACATCAAGGTGGAAGTTCTGGGCCCCAAGGAAGTCG
CCAAACTGGGCATGGGGTCCTTCATGGCCGTGGCCCAGGGTACGTCGGAGCCCCTGCGTTTTATCGTGCTGCGTTATGAA
GGCGCTGCCAAGTCGGTGGCGCCCGTCGTGCTGATCGGCAAGGGCATCACTTTCGATACGGGCGGCATCTCGATCAAGCC
GGCGGCCGAGATGGATGAGATGAAGTTCGACATGTGCGGCGCAGCCAGTGTGCTGGGCACGTTCCGGGCACTGGCCGAAT
TGCAGCCTGCGCTGAATGTGGTCGGGCTGATCCCGGCCTCTGAGAACATGCCCGGCGGGCGGGCGCTCAAGCCGGGCGAC
GTGGTCACCAGCATGAGCGGGCAGACCATTGAAATTCTGAACACCGATGCGGAAGGTCGCCTGGTGCTGTGCGATGCCTT
GACCTACGCGGAGCGCTTCAAGCCAAGGGCCGTGGTTGATATCGCTACGCTGACCGGCGCCTGCGTCATCGCGTTGGGTG
GCGTCCGCAGCGGGCTGTTTTCAAACAATGACGAACTGGCCCAGTCGCTGGCGGCCGCGGGTGAGTCGTCGCTTGACCCG
TGCTGGAGAATGCCACTGGACGACGATTACGCAGAAGGACTGAAAACGAATTTTGCCGATGTGGCGAACGTGGCGGGACG
GGCGGGTGGCGCCGTGACCGCGGCGAAGTTCCTGCATCGTTTTGCAGGCAGTTTTCCGTGGGCTCACCTCGACATTGCCG
GTACAGCCTGGAAAGGCGGAGCGGCCAAGGGTGCGACCGGCCGGCCTGTGCCCTTGCTGCTGGACTATTTGCTGGGCCAG
GTCACCGCGGCCGCCCCGCGCAAGGCACAGCCCAAAGCCAGGTCCGCCAAGAGAAGCAAGCCTGTTTCCAGAACCCGGGC
ATGA

Upstream 100 bases:

>100_bases
GCTGCGGGCTAACTCTTTGCGAATCGAAGATTGGAATAACATGACTGACTAATTGCCGTAGCTATGCTTTATTGTTGTTT
TATTTGCTCAACCCTGAATT

Downstream 100 bases:

>100_bases
CCGAGATCGCCTTTCATTTCAACGTACCCGACAAGCTGGCCTACGGTTGCCGTTTGCTGCGCAAGGCGTATCTCAGCGGC
GCCAGCGTGGTGGTGACGGC

Product: PepA aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MDFELKLLPLARICSEKCDALLVLIPQDLSAGGDDPLSALAALALKAGDLEAKPGKLLSAYRTPGIAATRVVLAGVGDAS
PRNVRTAVNAAMANLKNGNTQRVVVSLAAMNNAQPEIVRAAVVACSEAAYVYSTTKSKVSPVKLQRVVIGVNELSVARPG
FDKALALVKGIEFAKEWANRPANHATPTLLAGAARELARLRNIKVEVLGPKEVAKLGMGSFMAVAQGTSEPLRFIVLRYE
GAAKSVAPVVLIGKGITFDTGGISIKPAAEMDEMKFDMCGAASVLGTFRALAELQPALNVVGLIPASENMPGGRALKPGD
VVTSMSGQTIEILNTDAEGRLVLCDALTYAERFKPRAVVDIATLTGACVIALGGVRSGLFSNNDELAQSLAAAGESSLDP
CWRMPLDDDYAEGLKTNFADVANVAGRAGGAVTAAKFLHRFAGSFPWAHLDIAGTAWKGGAAKGATGRPVPLLLDYLLGQ
VTAAAPRKAQPKARSAKRSKPVSRTRA

Sequences:

>Translated_507_residues
MDFELKLLPLARICSEKCDALLVLIPQDLSAGGDDPLSALAALALKAGDLEAKPGKLLSAYRTPGIAATRVVLAGVGDAS
PRNVRTAVNAAMANLKNGNTQRVVVSLAAMNNAQPEIVRAAVVACSEAAYVYSTTKSKVSPVKLQRVVIGVNELSVARPG
FDKALALVKGIEFAKEWANRPANHATPTLLAGAARELARLRNIKVEVLGPKEVAKLGMGSFMAVAQGTSEPLRFIVLRYE
GAAKSVAPVVLIGKGITFDTGGISIKPAAEMDEMKFDMCGAASVLGTFRALAELQPALNVVGLIPASENMPGGRALKPGD
VVTSMSGQTIEILNTDAEGRLVLCDALTYAERFKPRAVVDIATLTGACVIALGGVRSGLFSNNDELAQSLAAAGESSLDP
CWRMPLDDDYAEGLKTNFADVANVAGRAGGAVTAAKFLHRFAGSFPWAHLDIAGTAWKGGAAKGATGRPVPLLLDYLLGQ
VTAAAPRKAQPKARSAKRSKPVSRTRA
>Mature_507_residues
MDFELKLLPLARICSEKCDALLVLIPQDLSAGGDDPLSALAALALKAGDLEAKPGKLLSAYRTPGIAATRVVLAGVGDAS
PRNVRTAVNAAMANLKNGNTQRVVVSLAAMNNAQPEIVRAAVVACSEAAYVYSTTKSKVSPVKLQRVVIGVNELSVARPG
FDKALALVKGIEFAKEWANRPANHATPTLLAGAARELARLRNIKVEVLGPKEVAKLGMGSFMAVAQGTSEPLRFIVLRYE
GAAKSVAPVVLIGKGITFDTGGISIKPAAEMDEMKFDMCGAASVLGTFRALAELQPALNVVGLIPASENMPGGRALKPGD
VVTSMSGQTIEILNTDAEGRLVLCDALTYAERFKPRAVVDIATLTGACVIALGGVRSGLFSNNDELAQSLAAAGESSLDP
CWRMPLDDDYAEGLKTNFADVANVAGRAGGAVTAAKFLHRFAGSFPWAHLDIAGTAWKGGAAKGATGRPVPLLLDYLLGQ
VTAAAPRKAQPKARSAKRSKPVSRTRA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=327, Percent_Identity=42.8134556574924, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI47155554, Length=317, Percent_Identity=32.4921135646688, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1790710, Length=472, Percent_Identity=46.6101694915254, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI87082123, Length=323, Percent_Identity=37.1517027863777, Blast_Score=168, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=34.185303514377, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=181, Percent_Identity=35.9116022099448, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355725, Length=334, Percent_Identity=35.3293413173653, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24661038, Length=327, Percent_Identity=35.474006116208, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24662227, Length=439, Percent_Identity=31.2072892938497, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129969, Length=327, Percent_Identity=34.5565749235474, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI161077148, Length=327, Percent_Identity=33.9449541284404, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20130057, Length=327, Percent_Identity=33.9449541284404, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355645, Length=324, Percent_Identity=32.7160493827161, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24662223, Length=324, Percent_Identity=32.7160493827161, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922386, Length=351, Percent_Identity=31.9088319088319, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=32.9931972789116, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21357381, Length=355, Percent_Identity=32.112676056338, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=355, Percent_Identity=32.112676056338, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=355, Percent_Identity=32.112676056338, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=31.1284046692607, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=31.1284046692607, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=31.1284046692607, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_POLSJ (Q12AW5)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_549225.1
- ProteinModelPortal:   Q12AW5
- SMR:   Q12AW5
- STRING:   Q12AW5
- MEROPS:   M17.003
- GeneID:   4014944
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_2408
- NMPDR:   fig|296591.1.peg.3665
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- PhylomeDB:   Q12AW5
- ProtClustDB:   CLSK951414
- BioCyc:   PSP296591:BPRO_2408-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52826; Mature: 52826

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 266-266 ACT_SITE 340-340

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELKLLPLARICSEKCDALLVLIPQDLSAGGDDPLSALAALALKAGDLEAKPGKLLSA
CCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
YRTPGIAATRVVLAGVGDASPRNVRTAVNAAMANLKNGNTQRVVVSLAAMNNAQPEIVRA
HCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEHHCCCCHHHHHH
AVVACSEAAYVYSTTKSKVSPVKLQRVVIGVNELSVARPGFDKALALVKGIEFAKEWANR
HHHHHCCCEEEEECCCCCCCHHEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PANHATPTLLAGAARELARLRNIKVEVLGPKEVAKLGMGSFMAVAQGTSEPLRFIVLRYE
CCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCCHHHHHHCCCCCCEEEEEEEEC
GAAKSVAPVVLIGKGITFDTGGISIKPAAEMDEMKFDMCGAASVLGTFRALAELQPALNV
CCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
VGLIPASENMPGGRALKPGDVVTSMSGQTIEILNTDAEGRLVLCDALTYAERFKPRAVVD
EEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCEEE
IATLTGACVIALGGVRSGLFSNNDELAQSLAAAGESSLDPCWRMPLDDDYAEGLKTNFAD
HHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCHHH
VANVAGRAGGAVTAAKFLHRFAGSFPWAHLDIAGTAWKGGAAKGATGRPVPLLLDYLLGQ
HHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
VTAAAPRKAQPKARSAKRSKPVSRTRA
HHHCCCCCCCCHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MDFELKLLPLARICSEKCDALLVLIPQDLSAGGDDPLSALAALALKAGDLEAKPGKLLSA
CCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
YRTPGIAATRVVLAGVGDASPRNVRTAVNAAMANLKNGNTQRVVVSLAAMNNAQPEIVRA
HCCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEHHCCCCHHHHHH
AVVACSEAAYVYSTTKSKVSPVKLQRVVIGVNELSVARPGFDKALALVKGIEFAKEWANR
HHHHHCCCEEEEECCCCCCCHHEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PANHATPTLLAGAARELARLRNIKVEVLGPKEVAKLGMGSFMAVAQGTSEPLRFIVLRYE
CCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCCHHHHHHCCCCCCEEEEEEEEC
GAAKSVAPVVLIGKGITFDTGGISIKPAAEMDEMKFDMCGAASVLGTFRALAELQPALNV
CCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
VGLIPASENMPGGRALKPGDVVTSMSGQTIEILNTDAEGRLVLCDALTYAERFKPRAVVD
EEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCEEE
IATLTGACVIALGGVRSGLFSNNDELAQSLAAAGESSLDPCWRMPLDDDYAEGLKTNFAD
HHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCHHH
VANVAGRAGGAVTAAKFLHRFAGSFPWAHLDIAGTAWKGGAAKGATGRPVPLLLDYLLGQ
HHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
VTAAAPRKAQPKARSAKRSKPVSRTRA
HHHCCCCCCCCHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA