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The map label for this gene is ilvD1 [H]

Identifier: 91788166

GI number: 91788166

Start: 2389233

End: 2390972

Strand: Reverse

Name: ilvD1 [H]

Synonym: Bpro_2297

Alternate gene names: 91788166

Gene position: 2390972-2389233 (Counterclockwise)

Preceding gene: 91788167

Following gene: 91788165

Centisome position: 45.98

GC content: 64.66

Gene sequence:

>1740_bases
ATGAGCAAAAAAACCTACGAATCGCTGCGCAGCGCGCGCTGGTTCGCCCCCGACGATGTGCGCTCTTTTGGCCACCGCTC
GCGCGTGATGCAGCTGGGCTATGGCCCCGAAGACTGGGTCGGCAAGCCGGTGATCGCCATTGTGAACACCTGGAGCGACA
TCGGCACCTGCCACGGCCACTTCAAGCAGCGCGTGGAAGACGTCAAGCGCGGCGTGCTGCAGGCCGGCGGTTTCCCGATT
GAACTTCCGGCCATCTCGCTGTCGGAATCCATCGTCAAGCCCACCACCATGCTCTACCGCAACATGCTGGCCATGGAAAC
CGAAGAGCTGCTGCGCAGCCACCCGATCGACGGCGTGGTGTTGATGGGTGGCTGCGACAAGACCACGCCCGGCCTGCTGA
TGGGTGCGATGAGCGCGGGCATGCCCTGCATCTACCTGCCGGCTGGCCCCATGCTGAGCGGCAACGTCAAGGGCAAGGTG
CTGGGCTCGGGTTCAGACACCTGGAAATACTGGGACGACCGGCGCGCCGGCAAGATCAGCGCGGCCCAATGGCTGGAAGT
CGAAGGCGGCATTGCCCGCAGCCACGGCCACTGCATGACCATGGGCACGGCCAGCACCATGACGGGCATTGCCGAGGCCT
GCGGATTCACGCTGCCGGGTGCATCGTCCATTCCCGCAGTGGACGCCAACCACATCCGCATGGCCAGCGAATGTGGCCGC
CGCGTGGTCAGCATGGTCTGGGAAGACCTGACTCCGGCCAAAATGCTCAGCCGCGCCTCGTTTGAAAACGCCATCGTGAT
CGCCATGGCCATGGGTTGCTCGACCAACGCCATCATTCACCTGGTGGCCATGTCGCGCCGCGCCGGCGAGCACTGCGCCG
TGGGTCTGGACGACTTCGACGCCGCCAGCCGCAAGGTGCCCGTGATCGCCAATATCCGGCCCAGCGGCGACACCTACCTG
ATGGAAGACTTCTACTTCGCGGGTGGCATGCGCGGCATGATGAGCCGCTTGACCAGCCATCTGAAGCTGGACGCCATGAC
GGTCAGCGGCCGCACCCTGGGCGAAACGCTGGAAGGTGCCGAGGTCTACAACGACGACGTGATCCGGCCACTGGACAATC
CCATTTATGCCGAAGGCGCGCTCGCCGTGCTGCGCGGCAACCTGGCGCCCGGCGGCTGCGTGATCAAGCCCAGCGCGTGC
GCCCCGAAGTTCCTGAAGCACACTGGCCCGGCCCTGGTGTTTGACGACTACCCATCCATGAAGGCAGCCGTTGACGACGA
GAACCTTGACGTCACAGAAAACCATGTCATGGTGCTGCGCAACGCCGGCCCGCAGGGCGGCCCGGGCATGCCCGAGTGGG
GCATGTTGCCCATTCCCCTGAAGCTGGTGAAGCAGGGCGTGAAAGACATGGTGCGCATTTCAGACGCCCGCATGAGTGGA
ACGAGCTACGGCGCATGCATCCTGCATGTGGCGCCTGAAGCCTACATCGGCGGCCCGCTGGCACTGGTCAAAACCGGCGA
CCTGATTTCGGTGGACGTGCCAGGCCGGCGCATTCACCTGGAGGTCAGCGACGAAGAACTGGCGCAGCGCCGGGCCGCCT
GGACGCCGCTGCCCAAACGCTATGAACGCGGCTACGGCTGGATGGCCGCGCGCCATATCCAGCAGGCCGACCAGGGCTGT
GATTTTGATTTTCTGGAAACCTCGTTTGGCGCGCCGGTGGGCGAGCCCGACATTTACTGA

Upstream 100 bases:

>100_bases
TTCCACCCATTGCACCAGGCCCTGATCGCCGACCTCAAGCCCTACTTTGAATGGGCGGCGGTGGATTACACGCTGTGAAC
CCCGAGACCCAAGGATTGAC

Downstream 100 bases:

>100_bases
CACGAACAGACACGAACAACACGAAGTGATAGGAAGGACTCCCATGACCCTCAAAGCCGAAACCCGCGACAAGCTCAAAA
CCGTCAGCACCGCCACGCTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSKKTYESLRSARWFAPDDVRSFGHRSRVMQLGYGPEDWVGKPVIAIVNTWSDIGTCHGHFKQRVEDVKRGVLQAGGFPI
ELPAISLSESIVKPTTMLYRNMLAMETEELLRSHPIDGVVLMGGCDKTTPGLLMGAMSAGMPCIYLPAGPMLSGNVKGKV
LGSGSDTWKYWDDRRAGKISAAQWLEVEGGIARSHGHCMTMGTASTMTGIAEACGFTLPGASSIPAVDANHIRMASECGR
RVVSMVWEDLTPAKMLSRASFENAIVIAMAMGCSTNAIIHLVAMSRRAGEHCAVGLDDFDAASRKVPVIANIRPSGDTYL
MEDFYFAGGMRGMMSRLTSHLKLDAMTVSGRTLGETLEGAEVYNDDVIRPLDNPIYAEGALAVLRGNLAPGGCVIKPSAC
APKFLKHTGPALVFDDYPSMKAAVDDENLDVTENHVMVLRNAGPQGGPGMPEWGMLPIPLKLVKQGVKDMVRISDARMSG
TSYGACILHVAPEAYIGGPLALVKTGDLISVDVPGRRIHLEVSDEELAQRRAAWTPLPKRYERGYGWMAARHIQQADQGC
DFDFLETSFGAPVGEPDIY

Sequences:

>Translated_579_residues
MSKKTYESLRSARWFAPDDVRSFGHRSRVMQLGYGPEDWVGKPVIAIVNTWSDIGTCHGHFKQRVEDVKRGVLQAGGFPI
ELPAISLSESIVKPTTMLYRNMLAMETEELLRSHPIDGVVLMGGCDKTTPGLLMGAMSAGMPCIYLPAGPMLSGNVKGKV
LGSGSDTWKYWDDRRAGKISAAQWLEVEGGIARSHGHCMTMGTASTMTGIAEACGFTLPGASSIPAVDANHIRMASECGR
RVVSMVWEDLTPAKMLSRASFENAIVIAMAMGCSTNAIIHLVAMSRRAGEHCAVGLDDFDAASRKVPVIANIRPSGDTYL
MEDFYFAGGMRGMMSRLTSHLKLDAMTVSGRTLGETLEGAEVYNDDVIRPLDNPIYAEGALAVLRGNLAPGGCVIKPSAC
APKFLKHTGPALVFDDYPSMKAAVDDENLDVTENHVMVLRNAGPQGGPGMPEWGMLPIPLKLVKQGVKDMVRISDARMSG
TSYGACILHVAPEAYIGGPLALVKTGDLISVDVPGRRIHLEVSDEELAQRRAAWTPLPKRYERGYGWMAARHIQQADQGC
DFDFLETSFGAPVGEPDIY
>Mature_578_residues
SKKTYESLRSARWFAPDDVRSFGHRSRVMQLGYGPEDWVGKPVIAIVNTWSDIGTCHGHFKQRVEDVKRGVLQAGGFPIE
LPAISLSESIVKPTTMLYRNMLAMETEELLRSHPIDGVVLMGGCDKTTPGLLMGAMSAGMPCIYLPAGPMLSGNVKGKVL
GSGSDTWKYWDDRRAGKISAAQWLEVEGGIARSHGHCMTMGTASTMTGIAEACGFTLPGASSIPAVDANHIRMASECGRR
VVSMVWEDLTPAKMLSRASFENAIVIAMAMGCSTNAIIHLVAMSRRAGEHCAVGLDDFDAASRKVPVIANIRPSGDTYLM
EDFYFAGGMRGMMSRLTSHLKLDAMTVSGRTLGETLEGAEVYNDDVIRPLDNPIYAEGALAVLRGNLAPGGCVIKPSACA
PKFLKHTGPALVFDDYPSMKAAVDDENLDVTENHVMVLRNAGPQGGPGMPEWGMLPIPLKLVKQGVKDMVRISDARMSGT
SYGACILHVAPEAYIGGPLALVKTGDLISVDVPGRRIHLEVSDEELAQRRAAWTPLPKRYERGYGWMAARHIQQADQGCD
FDFLETSFGAPVGEPDIY

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=582, Percent_Identity=32.9896907216495, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1788157, Length=551, Percent_Identity=31.0344827586207, Blast_Score=179, Evalue=6e-46,
Organism=Escherichia coli, GI2367371, Length=489, Percent_Identity=31.0838445807771, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1786464, Length=454, Percent_Identity=32.15859030837, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=33.0909090909091, Blast_Score=256, Evalue=8e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62565; Mature: 62434

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKTYESLRSARWFAPDDVRSFGHRSRVMQLGYGPEDWVGKPVIAIVNTWSDIGTCHGH
CCCHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCHHHCCCCEEEEEECCHHHHHHHHH
FKQRVEDVKRGVLQAGGFPIELPAISLSESIVKPTTMLYRNMLAMETEELLRSHPIDGVV
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMGGCDKTTPGLLMGAMSAGMPCIYLPAGPMLSGNVKGKVLGSGSDTWKYWDDRRAGKIS
EECCCCCCCCHHHHHHHHCCCCEEEECCCCEECCCCCEEEEECCCCCCCCCCCCCCCCCC
AAQWLEVEGGIARSHGHCMTMGTASTMTGIAEACGFTLPGASSIPAVDANHIRMASECGR
HHHEEEECCCEECCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RVVSMVWEDLTPAKMLSRASFENAIVIAMAMGCSTNAIIHLVAMSRRAGEHCAVGLDDFD
HHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEHHHCCCCCCEEECCCCCC
AASRKVPVIANIRPSGDTYLMEDFYFAGGMRGMMSRLTSHLKLDAMTVSGRTLGETLEGA
CCCCCCCEEEEECCCCCCEEEHHHHHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHCCC
EVYNDDVIRPLDNPIYAEGALAVLRGNLAPGGCVIKPSACAPKFLKHTGPALVFDDYPSM
HHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCHHHHHHCCCEEEEECCCCC
KAAVDDENLDVTENHVMVLRNAGPQGGPGMPEWGMLPIPLKLVKQGVKDMVRISDARMSG
EEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TSYGACILHVAPEAYIGGPLALVKTGDLISVDVPGRRIHLEVSDEELAQRRAAWTPLPKR
CCCCEEEEEECCCHHCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCHHH
YERGYGWMAARHIQQADQGCDFDFLETSFGAPVGEPDIY
HHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKKTYESLRSARWFAPDDVRSFGHRSRVMQLGYGPEDWVGKPVIAIVNTWSDIGTCHGH
CCHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCHHHCCCCEEEEEECCHHHHHHHHH
FKQRVEDVKRGVLQAGGFPIELPAISLSESIVKPTTMLYRNMLAMETEELLRSHPIDGVV
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMGGCDKTTPGLLMGAMSAGMPCIYLPAGPMLSGNVKGKVLGSGSDTWKYWDDRRAGKIS
EECCCCCCCCHHHHHHHHCCCCEEEECCCCEECCCCCEEEEECCCCCCCCCCCCCCCCCC
AAQWLEVEGGIARSHGHCMTMGTASTMTGIAEACGFTLPGASSIPAVDANHIRMASECGR
HHHEEEECCCEECCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RVVSMVWEDLTPAKMLSRASFENAIVIAMAMGCSTNAIIHLVAMSRRAGEHCAVGLDDFD
HHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEHHHCCCCCCEEECCCCCC
AASRKVPVIANIRPSGDTYLMEDFYFAGGMRGMMSRLTSHLKLDAMTVSGRTLGETLEGA
CCCCCCCEEEEECCCCCCEEEHHHHHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHCCC
EVYNDDVIRPLDNPIYAEGALAVLRGNLAPGGCVIKPSACAPKFLKHTGPALVFDDYPSM
HHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCHHHHHHCCCEEEEECCCCC
KAAVDDENLDVTENHVMVLRNAGPQGGPGMPEWGMLPIPLKLVKQGVKDMVRISDARMSG
EEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TSYGACILHVAPEAYIGGPLALVKTGDLISVDVPGRRIHLEVSDEELAQRRAAWTPLPKR
CCCCEEEEEECCCHHCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCHHH
YERGYGWMAARHIQQADQGCDFDFLETSFGAPVGEPDIY
HHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]