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The map label for this gene is gyaR [H]

Identifier: 91788160

GI number: 91788160

Start: 2384288

End: 2385235

Strand: Reverse

Name: gyaR [H]

Synonym: Bpro_2291

Alternate gene names: 91788160

Gene position: 2385235-2384288 (Counterclockwise)

Preceding gene: 91788161

Following gene: 91788159

Centisome position: 45.87

GC content: 64.87

Gene sequence:

>948_bases
ATGAAACCCAGACTCCTGCAGCACGTAGCCATACCCCCCCTGCTCGCGACCGAATTCAACACCCGCTATGACGCGCATCC
CCTCTGGAAGGAGGCCGACCCCGCAGCCTTCCTCGCCCGGCATGGCCATGAATTCACCGGCTACGTGACCAGCGCGCGCT
TTGGTGTGGACGATGCCACCCTGGCGGCGATGCCCAACCTCAAGGTGATTTCCAGCTTCGGCGTGGGCACTGAAACCCTG
CCTCTGGAGGCCGCCCAGGCCCGCGGCATCGCGGTAGGCTACACACCGGATGTCCTGAATGACTGCGTGGCCGACACGGC
TTTTGGACTGGTGATGGATGTGGCGCGCCGCTTCAGTGCCTCAGACCGGTTCGTGCGTGCCAGGCGCTGGCTGCAGGGCG
CTTATCCGCTGGCCACGCGGGTCAGCGGCAAGCAGCTGGGCATCCTCGGGCTGGGTCGCATTGGCCAGGTCGTCGCGCGC
CGCGCCAGCGGTTTTGACATGGAAGTGCGCTACCACAATCGTCGCCCGAATCCGGCGGTTCCCTACACCTACGAATCGTC
CATCGAGTCACTGGCCCGTTGGGCGGATTTTCTGGTGGTCGTGAGCGCCGGTGGCCCCGAAACCCGCCACCTGGTAACGG
CCAGCGTGCTACGCGCACTGGGCCCCCAAGGCTTTCTGATCAATGTGTCGCGGGGTTCGGTGATCGACGAAGACGCCCTG
ATTCAGGCACTGGAAGAAGGCACCATCGCCGGCGCCGGCCTGGATGTGTATGCGGATGAGCCACGCATACCCGAGCGGCT
GCTGGCACTGGACCAAGTGGTATTGCTGCCGCACCTGGCAAGCGCCACCAATGAGACACGCCAGGCCATGGCCGAGCTGG
TGGTGGACAACCTGGACGCTTTTTACGCGACCGGCAAGCTACGGGCCAGCGTTCCGCTGCCAGCCTAA

Upstream 100 bases:

>100_bases
TGGGGCCTGACGCCTGCTGCTGCGCCAGGCCAGCAAAACCCCAAACCCCAAACCACTGACTGTTTGACTCCCGGCCTCCT
TGACTCCCTCTTACAAACCC

Downstream 100 bases:

>100_bases
GCTTCGTCCCCGGGTTCCGCTGAGCGGGTGCGGGCGAGGCGGGCGCAGCGATGTATACATTTTTGCAACGGGATGCGCCG
TCCCGGCAATAACCCATGGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKPRLLQHVAIPPLLATEFNTRYDAHPLWKEADPAAFLARHGHEFTGYVTSARFGVDDATLAAMPNLKVISSFGVGTETL
PLEAAQARGIAVGYTPDVLNDCVADTAFGLVMDVARRFSASDRFVRARRWLQGAYPLATRVSGKQLGILGLGRIGQVVAR
RASGFDMEVRYHNRRPNPAVPYTYESSIESLARWADFLVVVSAGGPETRHLVTASVLRALGPQGFLINVSRGSVIDEDAL
IQALEEGTIAGAGLDVYADEPRIPERLLALDQVVLLPHLASATNETRQAMAELVVDNLDAFYATGKLRASVPLPA

Sequences:

>Translated_315_residues
MKPRLLQHVAIPPLLATEFNTRYDAHPLWKEADPAAFLARHGHEFTGYVTSARFGVDDATLAAMPNLKVISSFGVGTETL
PLEAAQARGIAVGYTPDVLNDCVADTAFGLVMDVARRFSASDRFVRARRWLQGAYPLATRVSGKQLGILGLGRIGQVVAR
RASGFDMEVRYHNRRPNPAVPYTYESSIESLARWADFLVVVSAGGPETRHLVTASVLRALGPQGFLINVSRGSVIDEDAL
IQALEEGTIAGAGLDVYADEPRIPERLLALDQVVLLPHLASATNETRQAMAELVVDNLDAFYATGKLRASVPLPA
>Mature_315_residues
MKPRLLQHVAIPPLLATEFNTRYDAHPLWKEADPAAFLARHGHEFTGYVTSARFGVDDATLAAMPNLKVISSFGVGTETL
PLEAAQARGIAVGYTPDVLNDCVADTAFGLVMDVARRFSASDRFVRARRWLQGAYPLATRVSGKQLGILGLGRIGQVVAR
RASGFDMEVRYHNRRPNPAVPYTYESSIESLARWADFLVVVSAGGPETRHLVTASVLRALGPQGFLINVSRGSVIDEDAL
IQALEEGTIAGAGLDVYADEPRIPERLLALDQVVLLPHLASATNETRQAMAELVVDNLDAFYATGKLRASVPLPA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=39.1836734693878, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=29.1970802919708, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4557497, Length=212, Percent_Identity=29.7169811320755, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI61743967, Length=212, Percent_Identity=29.7169811320755, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580578, Length=212, Percent_Identity=29.2452830188679, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4557499, Length=212, Percent_Identity=29.2452830188679, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI145580575, Length=212, Percent_Identity=29.2452830188679, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI87082289, Length=328, Percent_Identity=34.7560975609756, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=27.6752767527675, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=238, Percent_Identity=26.890756302521, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147481, Length=231, Percent_Identity=27.7056277056277, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=240, Percent_Identity=27.0833333333333, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=275, Percent_Identity=34.1818181818182, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=263, Percent_Identity=29.277566539924, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=263, Percent_Identity=29.277566539924, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=224, Percent_Identity=29.9107142857143, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=28.4883720930233, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=37.218045112782, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=33.7349397590361, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24585514, Length=245, Percent_Identity=33.8775510204082, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI28574282, Length=245, Percent_Identity=33.8775510204082, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=33.7349397590361, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45551003, Length=245, Percent_Identity=33.8775510204082, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=34.5528455284553, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24585516, Length=244, Percent_Identity=31.1475409836066, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=28.7719298245614, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=209, Percent_Identity=30.1435406698565, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646446, Length=209, Percent_Identity=30.1435406698565, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646448, Length=209, Percent_Identity=30.1435406698565, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646452, Length=209, Percent_Identity=30.1435406698565, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646450, Length=209, Percent_Identity=30.1435406698565, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34083; Mature: 34083

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRLLQHVAIPPLLATEFNTRYDAHPLWKEADPAAFLARHGHEFTGYVTSARFGVDDAT
CCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCHH
LAAMPNLKVISSFGVGTETLPLEAAQARGIAVGYTPDVLNDCVADTAFGLVMDVARRFSA
HHHCCCCCEEHHCCCCCCCCCCHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
SDRFVRARRWLQGAYPLATRVSGKQLGILGLGRIGQVVARRASGFDMEVRYHNRRPNPAV
CHHHHHHHHHHCCCCCHHEECCCCEECEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCC
PYTYESSIESLARWADFLVVVSAGGPETRHLVTASVLRALGPQGFLINVSRGSVIDEDAL
CCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
IQALEEGTIAGAGLDVYADEPRIPERLLALDQVVLLPHLASATNETRQAMAELVVDNLDA
HHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYATGKLRASVPLPA
HEECCCEEECCCCCC
>Mature Secondary Structure
MKPRLLQHVAIPPLLATEFNTRYDAHPLWKEADPAAFLARHGHEFTGYVTSARFGVDDAT
CCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCHH
LAAMPNLKVISSFGVGTETLPLEAAQARGIAVGYTPDVLNDCVADTAFGLVMDVARRFSA
HHHCCCCCEEHHCCCCCCCCCCHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
SDRFVRARRWLQGAYPLATRVSGKQLGILGLGRIGQVVARRASGFDMEVRYHNRRPNPAV
CHHHHHHHHHHCCCCCHHEECCCCEECEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCC
PYTYESSIESLARWADFLVVVSAGGPETRHLVTASVLRALGPQGFLINVSRGSVIDEDAL
CCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
IQALEEGTIAGAGLDVYADEPRIPERLLALDQVVLLPHLASATNETRQAMAELVVDNLDA
HHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYATGKLRASVPLPA
HEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA