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The map label for this gene is moeA [H]

Identifier: 91788155

GI number: 91788155

Start: 2378287

End: 2379642

Strand: Reverse

Name: moeA [H]

Synonym: Bpro_2286

Alternate gene names: 91788155

Gene position: 2379642-2378287 (Counterclockwise)

Preceding gene: 91788156

Following gene: 91788148

Centisome position: 45.76

GC content: 64.68

Gene sequence:

>1356_bases
GTGAAAACACTGGAGCAGATTGCCACCGAACTGCAGGGCTATGACCCGCAGGCCATGTCGGCCGCCGATGTGCTGGCATT
TTTGTCCCGTCTGGCCGTGCCCGTTCAGGATGTTGTCGAGTTGCCTTTGTTCGAAGCCTTCGGCCGGGTGCTGGCGGACG
ATGTGATTTCGCCGTTTGACGTGCCGCCTCATGACAACTCGGCCATGGACGGCTACGCGTTTGACGGCCGCCAATTGGCA
GCCAATGCCGCGCTTGAACTCGAGGTGGTGGGCACGGCGCTGGCGGGCAAGGCCTGGCAAGGCAGCGTTCTGCCAGGCCA
GTGCGTCAAGATCATGACCGGTGCCATCATGCCGCCGGGGCTGGACACCGTGGTGCCCCAGGAGTTCACCAAGCTGCAGC
CTGGCCGCGAATCCGCTGAAAACGCCCGCGCCAGCATTCCGCCCGGCTTGTTGAGCGCCGGTGACAACCGCCGCCTGCGC
GGCGAAGACCTGATTCGGGGCAAACCCGCGCTACGCAAAGGCGAGCTGCTGACCCCCGCCCGCCTTGGGCTGGCGGCCTC
CTTGGGCCTTGAAACCCTGAAAACCTGGCGGCCGCTGCGGGTCGCCTACTTTTCCACTGGCGACGAGATTTTGTCGCTGG
GCGAAGCACCCCGTGAAGGCGCCGTGTACGACAGCAACCGCTACACCGTCTTCGGCATGCTGAGCCGCCTGGGGTGCCAG
GTGATAGACATGGGTGTGGTGCGTGACGACCCGGCGCTGCTCGAAGCGACATTTTCCCGCGCAGCGGCACAGGCCGATGC
CGTCATCACTTCGGGCGGCGTCAGTGTGGGCGAGGCCGACTTCACCAAGGCCATGATGAAAAAACTGGGTGACGTCGCCT
TCTGGCGCATTGCCATGCGACCAGGCCGTCCCATGGCGGTCGGGCGCATCCTGCCGGCAAAATCCGCACTCAGCCCAGAC
TCAACCGGGCAAGATGGCGATCAACAACATGGCAACCCTCACGGTGCGATCCTGTTTGGCCTGCCAGGCAACCCCGTGGC
GGTGATGGTCACTTTTCTGGCGTTTGTGCGCCCTGCCTTGCTGCAGATGATGGGCGCGAATGCGGCAGCACCACCGCTAC
TCAGGGCGCGCAGCACGGAAGCCATCCGCAAAAAACCGGGGCGCACCGAGTACCAGCGCGGCTGGGTGTCCACAGCGCCC
GACGGCTCGCTGCAGGTCAGGACCACCGGCAACCAGGGCTCCGGTGTGCTCAGCTCCATGGCCGAGGCCAACGGCCTGAT
CATGTTGCACCACGGTCAGGGCAGCGTGGCGGTGGGTGACGAGGTTGATGTGATGATGTTCGAGGGCGTCCTCTAA

Upstream 100 bases:

>100_bases
AGACAGTCCTTGTGCCGTTTGACCGGCCCACGGACGACGCGCGCGGCTTTTTCAATGCCAACACGCTGGCTGAGCTGCAC
CAGCTGGAATCCCGCCTGCC

Downstream 100 bases:

>100_bases
CCCGCCCACTAAACCAGCCGCAGCACGGCGATCGGCGGCAAGTCCCGTGACAGGCACTGCCAGGAGACCCCGGCGTCTTC
GCTGACCCACAGGCCGCCCG

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKTLEQIATELQGYDPQAMSAADVLAFLSRLAVPVQDVVELPLFEAFGRVLADDVISPFDVPPHDNSAMDGYAFDGRQLA
ANAALELEVVGTALAGKAWQGSVLPGQCVKIMTGAIMPPGLDTVVPQEFTKLQPGRESAENARASIPPGLLSAGDNRRLR
GEDLIRGKPALRKGELLTPARLGLAASLGLETLKTWRPLRVAYFSTGDEILSLGEAPREGAVYDSNRYTVFGMLSRLGCQ
VIDMGVVRDDPALLEATFSRAAAQADAVITSGGVSVGEADFTKAMMKKLGDVAFWRIAMRPGRPMAVGRILPAKSALSPD
STGQDGDQQHGNPHGAILFGLPGNPVAVMVTFLAFVRPALLQMMGANAAAPPLLRARSTEAIRKKPGRTEYQRGWVSTAP
DGSLQVRTTGNQGSGVLSSMAEANGLIMLHHGQGSVAVGDEVDVMMFEGVL

Sequences:

>Translated_451_residues
MKTLEQIATELQGYDPQAMSAADVLAFLSRLAVPVQDVVELPLFEAFGRVLADDVISPFDVPPHDNSAMDGYAFDGRQLA
ANAALELEVVGTALAGKAWQGSVLPGQCVKIMTGAIMPPGLDTVVPQEFTKLQPGRESAENARASIPPGLLSAGDNRRLR
GEDLIRGKPALRKGELLTPARLGLAASLGLETLKTWRPLRVAYFSTGDEILSLGEAPREGAVYDSNRYTVFGMLSRLGCQ
VIDMGVVRDDPALLEATFSRAAAQADAVITSGGVSVGEADFTKAMMKKLGDVAFWRIAMRPGRPMAVGRILPAKSALSPD
STGQDGDQQHGNPHGAILFGLPGNPVAVMVTFLAFVRPALLQMMGANAAAPPLLRARSTEAIRKKPGRTEYQRGWVSTAP
DGSLQVRTTGNQGSGVLSSMAEANGLIMLHHGQGSVAVGDEVDVMMFEGVL
>Mature_451_residues
MKTLEQIATELQGYDPQAMSAADVLAFLSRLAVPVQDVVELPLFEAFGRVLADDVISPFDVPPHDNSAMDGYAFDGRQLA
ANAALELEVVGTALAGKAWQGSVLPGQCVKIMTGAIMPPGLDTVVPQEFTKLQPGRESAENARASIPPGLLSAGDNRRLR
GEDLIRGKPALRKGELLTPARLGLAASLGLETLKTWRPLRVAYFSTGDEILSLGEAPREGAVYDSNRYTVFGMLSRLGCQ
VIDMGVVRDDPALLEATFSRAAAQADAVITSGGVSVGEADFTKAMMKKLGDVAFWRIAMRPGRPMAVGRILPAKSALSPD
STGQDGDQQHGNPHGAILFGLPGNPVAVMVTFLAFVRPALLQMMGANAAAPPLLRARSTEAIRKKPGRTEYQRGWVSTAP
DGSLQVRTTGNQGSGVLSSMAEANGLIMLHHGQGSVAVGDEVDVMMFEGVL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=431, Percent_Identity=33.4106728538283, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI66932975, Length=433, Percent_Identity=33.7182448036951, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1787049, Length=411, Percent_Identity=41.3625304136253, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25147659, Length=399, Percent_Identity=29.8245614035088, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=384, Percent_Identity=25.2604166666667, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=28.3292978208232, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=28.3292978208232, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47695; Mature: 47695

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLEQIATELQGYDPQAMSAADVLAFLSRLAVPVQDVVELPLFEAFGRVLADDVISPFD
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VPPHDNSAMDGYAFDGRQLAANAALELEVVGTALAGKAWQGSVLPGQCVKIMTGAIMPPG
CCCCCCCCCCCCCCCCHHHHCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
LDTVVPQEFTKLQPGRESAENARASIPPGLLSAGDNRRLRGEDLIRGKPALRKGELLTPA
CCCCCCHHHHHCCCCCHHHHCCCCCCCCHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCHH
RLGLAASLGLETLKTWRPLRVAYFSTGDEILSLGEAPREGAVYDSNRYTVFGMLSRLGCQ
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCEECCCCEEHHHHHHHHCCE
VIDMGVVRDDPALLEATFSRAAAQADAVITSGGVSVGEADFTKAMMKKLGDVAFWRIAMR
EEEECEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEC
PGRPMAVGRILPAKSALSPDSTGQDGDQQHGNPHGAILFGLPGNPVAVMVTFLAFVRPAL
CCCCEECCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LQMMGANAAAPPLLRARSTEAIRKKPGRTEYQRGWVSTAPDGSLQVRTTGNQGSGVLSSM
HHHHCCCCCCCCHHHHCCHHHHHCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHH
AEANGLIMLHHGQGSVAVGDEVDVMMFEGVL
HHCCCEEEEECCCCCEEECCCCEEEEECCCC
>Mature Secondary Structure
MKTLEQIATELQGYDPQAMSAADVLAFLSRLAVPVQDVVELPLFEAFGRVLADDVISPFD
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VPPHDNSAMDGYAFDGRQLAANAALELEVVGTALAGKAWQGSVLPGQCVKIMTGAIMPPG
CCCCCCCCCCCCCCCCHHHHCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
LDTVVPQEFTKLQPGRESAENARASIPPGLLSAGDNRRLRGEDLIRGKPALRKGELLTPA
CCCCCCHHHHHCCCCCHHHHCCCCCCCCHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCHH
RLGLAASLGLETLKTWRPLRVAYFSTGDEILSLGEAPREGAVYDSNRYTVFGMLSRLGCQ
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCEECCCCEEHHHHHHHHCCE
VIDMGVVRDDPALLEATFSRAAAQADAVITSGGVSVGEADFTKAMMKKLGDVAFWRIAMR
EEEECEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEC
PGRPMAVGRILPAKSALSPDSTGQDGDQQHGNPHGAILFGLPGNPVAVMVTFLAFVRPAL
CCCCEECCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LQMMGANAAAPPLLRARSTEAIRKKPGRTEYQRGWVSTAPDGSLQVRTTGNQGSGVLSSM
HHHHCCCCCCCCHHHHCCHHHHHCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHH
AEANGLIMLHHGQGSVAVGDEVDVMMFEGVL
HHCCCEEEEECCCCCEEECCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]