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The map label for this gene is trxA [H]

Identifier: 91788134

GI number: 91788134

Start: 2351240

End: 2351572

Strand: Reverse

Name: trxA [H]

Synonym: Bpro_2263

Alternate gene names: 91788134

Gene position: 2351572-2351240 (Counterclockwise)

Preceding gene: 91788148

Following gene: 91788133

Centisome position: 45.22

GC content: 55.86

Gene sequence:

>333_bases
ATGGCGAGCGAATTGATCAAACATACCACCGATGCCACGTTTGAAGCCGACGTGCTGAAATCTTCAACACCCGTTCTGGT
GGACTATTGGGCCGAATGGTGCGGCCCTTGCAAGATGATTGCCCCCATCCTGGACGAAGTGGCCACCGGCTATGACGGCA
AGTTGCAGATCGCCAAAATGAATGTCGATGAAAACCGCGACATTCCCGCCAAATTCGGCATTCGTGGCATTCCCACGCTG
ATGCTGTTCAAGGACGGCCAGCTGGCAGCCACCAAGGTCGGCGCCATGAGCAAGGCCCAGTTGACCGCATTCATTGACCA
GCAACTGGCCTGA

Upstream 100 bases:

>100_bases
GCCCATAGCGGCTGCATGAGCGACCCGGTTACTTGCTTTCTGACACAATGACTGCAACTTTAGCCGTATCTAATCTAGTA
ACTAGACCAAAGGAGCCGTC

Downstream 100 bases:

>100_bases
GCGCCACTGAGACTGGACCTGTCGCCGTGCCATCAGGAACCGGATTACCCCGGCTTCCTGATCCGGCACCGCCTTGATGA
CTGCCCCGCGCAACTGCCCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MASELIKHTTDATFEADVLKSSTPVLVDYWAEWCGPCKMIAPILDEVATGYDGKLQIAKMNVDENRDIPAKFGIRGIPTL
MLFKDGQLAATKVGAMSKAQLTAFIDQQLA

Sequences:

>Translated_110_residues
MASELIKHTTDATFEADVLKSSTPVLVDYWAEWCGPCKMIAPILDEVATGYDGKLQIAKMNVDENRDIPAKFGIRGIPTL
MLFKDGQLAATKVGAMSKAQLTAFIDQQLA
>Mature_109_residues
ASELIKHTTDATFEADVLKSSTPVLVDYWAEWCGPCKMIAPILDEVATGYDGKLQIAKMNVDENRDIPAKFGIRGIPTLM
LFKDGQLAATKVGAMSKAQLTAFIDQQLA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=35.8695652173913, Blast_Score=80, Evalue=3e-16,
Organism=Homo sapiens, GI21361657, Length=101, Percent_Identity=31.6831683168317, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI5031973, Length=98, Percent_Identity=29.5918367346939, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=62.962962962963, Blast_Score=150, Evalue=2e-38,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=34.2592592592593, Blast_Score=70, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=40.2061855670103, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=45.0704225352113, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=34.1463414634146, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=62, Percent_Identity=40.3225806451613, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=62, Percent_Identity=40.3225806451613, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=89, Percent_Identity=37.0786516853933, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=45.0704225352113, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=35.5555555555556, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=42.2535211267606, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324862, Length=104, Percent_Identity=28.8461538461538, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=41.25, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=29.5918367346939, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=40.9836065573771, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11990; Mature: 11859

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASELIKHTTDATFEADVLKSSTPVLVDYWAEWCGPCKMIAPILDEVATGYDGKLQIAKM
CCCHHHHHCCCCCEEHHHHCCCCCCCEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEE
NVDENRDIPAKFGIRGIPTLMLFKDGQLAATKVGAMSKAQLTAFIDQQLA
CCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ASELIKHTTDATFEADVLKSSTPVLVDYWAEWCGPCKMIAPILDEVATGYDGKLQIAKM
CCHHHHHCCCCCEEHHHHCCCCCCCEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEE
NVDENRDIPAKFGIRGIPTLMLFKDGQLAATKVGAMSKAQLTAFIDQQLA
CCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]