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The map label for this gene is norM [H]

Identifier: 91788130

GI number: 91788130

Start: 2345838

End: 2347205

Strand: Reverse

Name: norM [H]

Synonym: Bpro_2259

Alternate gene names: 91788130

Gene position: 2347205-2345838 (Counterclockwise)

Preceding gene: 91788131

Following gene: 91788122

Centisome position: 45.14

GC content: 64.25

Gene sequence:

>1368_bases
TTGAGCGAACTCAAAATCATCAGCCAGCACGCGGGTACGGTGCTGGTGGGTCAGCTGGCCGTGATGGCCTTTGGCGTGGC
AGACACCGTGATTGCCGGGCGCTACAGCGACGAGGCCCTGGCTGCGCTGTCGGTAGGCTCCGCCATCTACATCAGTGTTT
ACGTCGGGCTGATTGGCATTGTCCAGGCCCTGCTCCCCATCTGGGCCGAGATGCGGGGTGCCCGACAGTATGAGGCGGTC
GGACAATCCTTGCGGCAAAGTCTTTACCTGTGCAGCTTCATCACGGCCGCCGGCATGGCTGCCCTGCTGTTTCCCGGCCC
GCTGCTGCGCTGGGCACAGGTGCCCGAACTGATGCAGGATGACGTGCGGCACTACCTCGCCATTCTGGCCTTCGGGTTTG
TTCCCTCGCTGCTGTTCCGGGTTTACAGCACGTTCAACCAGTCCCTGGGAAAACCGCTGCTGGTCACCTGGCTGCAGGTA
GGCGCGTTGGCGCTCAAAATCCCGCTGTCCATCTGGCTGGTGGCTGGCGGTGGCGGCGTGGAGCCCATGGGTGTCGCCGG
CTGCGCCTTGGCCACGCTGATCGTGAACTACCTGCTTCTGGTGCTGGCGCTGGTGATGCTGCGCTCACAAGCGCTATACA
GGCCGTTTTGCATCTGGCGGCGCATGGAGCGTCCCGACTGGCCGCAGATTCGCGGCTTTGCCCGGCTGGGTATCCCCGGT
GGGCTGGCCTATCTGGTGGAAGTGACCTCCTTCACACTGATGGCCCTGTTCATCGCGCGATTGGGAACGACGGCCTCGGC
GAGCCACCAGATCGCGGCCAGCGTGGCGGCGGTGCTTTACATGATGCCGCTGTCCATGGCCATTGCCTGCAGTGCGCGCG
TATCGTTCTGGCTGGGTGCGGAACGGCCGGACTACGCCAGGCGGGTGGTCGTGCTGGGCCTGAAACTCACAGGGCTGGCG
GCCCTGGTACTGGCTGCGACTATTTCGGTAGCAGGGAAGCTGCTGGCAAGCTGGTATTCCGGCAGCCCAGCGATCATTTC
CCTGGCGTCGTCCCTGCTGGTGTGGGTGGCTTTTTACCACGTCGCCGATGCCACCCAGGCACTGTGCGCCTTCTTGCTGC
GCTGCTACCGCATCACGCTCACGCCACTGGTACTGTATGGAATTTTCCTGTGGGGGCTGGGCCTGTTTGGCGGTTACCTG
CTGGCCTACGAAGGTATCGCGGGCCGTGCCGCCACCCAATCGGCCAGCAGCTTCTGGGCTGCCAGCACCATCGCGATCGG
ACTGGCAGCCGCCTGCCTCCTGGGGTTGCTGTGGCGCGTGGTTTGGCAGAGCCAGCGGGCCATCCCGGGGAAAACTCAGG
CAGCGTGA

Upstream 100 bases:

>100_bases
GCAGACCGACGGACAAAAATGAGAACGTCCTGGTTTTCAAACGGGTCAGCACGGATAACCAGGCCCGGGCGGCAAAGCGA
GACGGTCTGCCCGCCCGCCC

Downstream 100 bases:

>100_bases
GCCGGGCGGATGCGTGCCGCGGGGAAAATGAGTGAAAAGCGCGAACCGTGCCCGGGCTGGCTGTCGATATGCAGTTCGGC
ACCGTGGCGCTGGGCGACAT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSELKIISQHAGTVLVGQLAVMAFGVADTVIAGRYSDEALAALSVGSAIYISVYVGLIGIVQALLPIWAEMRGARQYEAV
GQSLRQSLYLCSFITAAGMAALLFPGPLLRWAQVPELMQDDVRHYLAILAFGFVPSLLFRVYSTFNQSLGKPLLVTWLQV
GALALKIPLSIWLVAGGGGVEPMGVAGCALATLIVNYLLLVLALVMLRSQALYRPFCIWRRMERPDWPQIRGFARLGIPG
GLAYLVEVTSFTLMALFIARLGTTASASHQIAASVAAVLYMMPLSMAIACSARVSFWLGAERPDYARRVVVLGLKLTGLA
ALVLAATISVAGKLLASWYSGSPAIISLASSLLVWVAFYHVADATQALCAFLLRCYRITLTPLVLYGIFLWGLGLFGGYL
LAYEGIAGRAATQSASSFWAASTIAIGLAAACLLGLLWRVVWQSQRAIPGKTQAA

Sequences:

>Translated_455_residues
MSELKIISQHAGTVLVGQLAVMAFGVADTVIAGRYSDEALAALSVGSAIYISVYVGLIGIVQALLPIWAEMRGARQYEAV
GQSLRQSLYLCSFITAAGMAALLFPGPLLRWAQVPELMQDDVRHYLAILAFGFVPSLLFRVYSTFNQSLGKPLLVTWLQV
GALALKIPLSIWLVAGGGGVEPMGVAGCALATLIVNYLLLVLALVMLRSQALYRPFCIWRRMERPDWPQIRGFARLGIPG
GLAYLVEVTSFTLMALFIARLGTTASASHQIAASVAAVLYMMPLSMAIACSARVSFWLGAERPDYARRVVVLGLKLTGLA
ALVLAATISVAGKLLASWYSGSPAIISLASSLLVWVAFYHVADATQALCAFLLRCYRITLTPLVLYGIFLWGLGLFGGYL
LAYEGIAGRAATQSASSFWAASTIAIGLAAACLLGLLWRVVWQSQRAIPGKTQAA
>Mature_454_residues
SELKIISQHAGTVLVGQLAVMAFGVADTVIAGRYSDEALAALSVGSAIYISVYVGLIGIVQALLPIWAEMRGARQYEAVG
QSLRQSLYLCSFITAAGMAALLFPGPLLRWAQVPELMQDDVRHYLAILAFGFVPSLLFRVYSTFNQSLGKPLLVTWLQVG
ALALKIPLSIWLVAGGGGVEPMGVAGCALATLIVNYLLLVLALVMLRSQALYRPFCIWRRMERPDWPQIRGFARLGIPGG
LAYLVEVTSFTLMALFIARLGTTASASHQIAASVAAVLYMMPLSMAIACSARVSFWLGAERPDYARRVVVLGLKLTGLAA
LVLAATISVAGKLLASWYSGSPAIISLASSLLVWVAFYHVADATQALCAFLLRCYRITLTPLVLYGIFLWGLGLFGGYLL
AYEGIAGRAATQSASSFWAASTIAIGLAAACLLGLLWRVVWQSQRAIPGKTQAA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=27.3348519362187, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321821, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=156, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48670; Mature: 48539

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKIISQHAGTVLVGQLAVMAFGVADTVIAGRYSDEALAALSVGSAIYISVYVGLIGI
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHH
VQALLPIWAEMRGARQYEAVGQSLRQSLYLCSFITAAGMAALLFPGPLLRWAQVPELMQD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DVRHYLAILAFGFVPSLLFRVYSTFNQSLGKPLLVTWLQVGALALKIPLSIWLVAGGGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCCCC
EPMGVAGCALATLIVNYLLLVLALVMLRSQALYRPFCIWRRMERPDWPQIRGFARLGIPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHCCCCC
GLAYLVEVTSFTLMALFIARLGTTASASHQIAASVAAVLYMMPLSMAIACSARVSFWLGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
ERPDYARRVVVLGLKLTGLAALVLAATISVAGKLLASWYSGSPAIISLASSLLVWVAFYH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VADATQALCAFLLRCYRITLTPLVLYGIFLWGLGLFGGYLLAYEGIAGRAATQSASSFWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ASTIAIGLAAACLLGLLWRVVWQSQRAIPGKTQAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SELKIISQHAGTVLVGQLAVMAFGVADTVIAGRYSDEALAALSVGSAIYISVYVGLIGI
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHH
VQALLPIWAEMRGARQYEAVGQSLRQSLYLCSFITAAGMAALLFPGPLLRWAQVPELMQD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DVRHYLAILAFGFVPSLLFRVYSTFNQSLGKPLLVTWLQVGALALKIPLSIWLVAGGGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCCCC
EPMGVAGCALATLIVNYLLLVLALVMLRSQALYRPFCIWRRMERPDWPQIRGFARLGIPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHCCCCC
GLAYLVEVTSFTLMALFIARLGTTASASHQIAASVAAVLYMMPLSMAIACSARVSFWLGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
ERPDYARRVVVLGLKLTGLAALVLAATISVAGKLLASWYSGSPAIISLASSLLVWVAFYH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VADATQALCAFLLRCYRITLTPLVLYGIFLWGLGLFGGYLLAYEGIAGRAATQSASSFWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ASTIAIGLAAACLLGLLWRVVWQSQRAIPGKTQAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA