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The map label for this gene is merA [H]

Identifier: 91788100

GI number: 91788100

Start: 2318937

End: 2320622

Strand: Reverse

Name: merA [H]

Synonym: Bpro_2228

Alternate gene names: 91788100

Gene position: 2320622-2318937 (Counterclockwise)

Preceding gene: 91788101

Following gene: 91788099

Centisome position: 44.63

GC content: 63.64

Gene sequence:

>1686_bases
ATGACCGACTTGAAGATCACCGGAATGACCTGCGACTCGTGCGCTGCGCATGTCAAGGAAGCCTTGGAGAAGGTGCCGGG
TGTGTTTTCTGCGGTCGTGTCCTACGCGAAGGGCACTGCGCAGCTCGCCACCGAGCTAGGCACGTCGCCGGATGCGCTGA
CTGCCGCCGTTGCCGGACTCGGCTACAAGGCCACGCTCGCGGATGCACCGACAGCCGAGAAGCGCGGCGGTCTGCTTGAT
AAAGCGCGTGGATGGCTGAGTGGTGGCGACAAATCAGTCGGCGATGGAGGCAAACTGCATATTGCCGTCATCGGTAGCGG
CGGCGCTGCGATGGCGGCGGCGCTAAAGGCCGCCGAGCAAGGCGCGAAGGTCACGCTGATCGAGCGCGGCACCATCGGCG
GCACTTGCGTCAATGTCGGTTGCGTGCCGTCCAAGATCATGATCCGCGCCGCCCATATCGCCCATCTGCGCCGTGAAAGT
CCATTCGACGACGGTATCGAGGCGACTGTGCCTGCGATTGACCGCCGCGAACTGCTGGCGCAGCAGCAGGCTCGCGTCGA
TGAACTGCGCCACGCCAAGTACGAGGGCATTCTGGACAGCAACCCGGCCATCAATGTGCTGCAGGGTGAAGCGCGTTTCA
AAGACGGCCAAAGCCTTGCCGTCGGTTTGAACGATGGCGGCGAGCGCGCGGTGGTGTTCGACCGCTGCCTGGTCGCCACC
GGCGCCAGCGCGGCAGTCCCGCCGATTCCCGGCCTGAAAGACACACCTTACTGGACCTCCATCGAGGCGCTGGTCAGCGA
CACGATTCCTCAGCGGCTGGCTGTGATCGGCTCGTCGGTGGTCGCGGTGGAGCTGGCACAAGCCTTTGCCCGACTGGGCA
GCCAGGTCACTATCCTGGCGCGCAGCACGCTGTTCTTCCGCGAAGACCCGGCTATCGGCGAGGCCGTCACAGCCGCCTTC
CGTGCGGAAGGGATCAAGGTGCTGGAACACACGCAAGCCAGCCACGTCGCTTATGCGGACGGTGAATTCCTGCTTACCAC
GGGACACGGCGAAGTACGTGCCGACAAGCTATTGGTCGCCACCGGCCGGGCGCCGAACACGCACAGCCTGGCACTGGAAG
CGGCGGGCGTCACCGTTAATGCGCAGGGTGCCATCGTCATCGACAAGTTCATGCGCACAAGTACCCCGCACGTCTACGCT
GCCGGCGACTGCACCGACCAACCGCAGTTCGTCTATGTGGCAGCGGCGGCCGGCACCCGTGCAGCGATCAACATGACCGG
TGGCGAAGCTGCCATTGATCTAAGCGTTATGCCGGCAGTGGTGTTCACCGACCCGCAAGTCGCCACCGTGGGCTACAGCG
AAGCGCAAGGGCACCATGACGGCATCGAGACGGACAGCCGGCTGCTCACGTTGGATAACGTACCACGTGCGCTCGCCAAC
TTCGATACGCGCGGCTTTATCAAGCTGGTTATTGAGGAAGGTAGCGGACGACTCATCGGCGTACAGGCGGTGGCCCCGGA
AGCGGGCGAGCTGATCCAGACGGCGGTGCTCGCCATACGTAACCGCATGACGGTGCAAGAACTGGCTGACCAGTTGTTCC
CATACTTGACGATGGTCGAGGGGCTGAAGCTCGCGGCACAGACCTTCAGCAAGGACGTAACGCAGCTTTCCTGCTGCGCC
GGATGA

Upstream 100 bases:

>100_bases
TCGCCAGCGAAGCGCCGCGGCGGACCGGACGGCTGCGCACTGCCGCCCCGGCGTGGCTGACGGCATTGGCCGTTGCCGAA
ACAGAAAAAGGAACTATTGC

Downstream 100 bases:

>100_bases
AGAAAAGAAGGTGTTCGATGAACGCCTGCACGGTGTCCCATCTGGCCCTGGATGCCGGTGTGAGTGTGCATGTCGTGCGC
GACTACATGCTGCGTGGGTT

Product: putative mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MTDLKITGMTCDSCAAHVKEALEKVPGVFSAVVSYAKGTAQLATELGTSPDALTAAVAGLGYKATLADAPTAEKRGGLLD
KARGWLSGGDKSVGDGGKLHIAVIGSGGAAMAAALKAAEQGAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES
PFDDGIEATVPAIDRRELLAQQQARVDELRHAKYEGILDSNPAINVLQGEARFKDGQSLAVGLNDGGERAVVFDRCLVAT
GASAAVPPIPGLKDTPYWTSIEALVSDTIPQRLAVIGSSVVAVELAQAFARLGSQVTILARSTLFFREDPAIGEAVTAAF
RAEGIKVLEHTQASHVAYADGEFLLTTGHGEVRADKLLVATGRAPNTHSLALEAAGVTVNAQGAIVIDKFMRTSTPHVYA
AGDCTDQPQFVYVAAAAGTRAAINMTGGEAAIDLSVMPAVVFTDPQVATVGYSEAQGHHDGIETDSRLLTLDNVPRALAN
FDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFSKDVTQLSCCA
G

Sequences:

>Translated_561_residues
MTDLKITGMTCDSCAAHVKEALEKVPGVFSAVVSYAKGTAQLATELGTSPDALTAAVAGLGYKATLADAPTAEKRGGLLD
KARGWLSGGDKSVGDGGKLHIAVIGSGGAAMAAALKAAEQGAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES
PFDDGIEATVPAIDRRELLAQQQARVDELRHAKYEGILDSNPAINVLQGEARFKDGQSLAVGLNDGGERAVVFDRCLVAT
GASAAVPPIPGLKDTPYWTSIEALVSDTIPQRLAVIGSSVVAVELAQAFARLGSQVTILARSTLFFREDPAIGEAVTAAF
RAEGIKVLEHTQASHVAYADGEFLLTTGHGEVRADKLLVATGRAPNTHSLALEAAGVTVNAQGAIVIDKFMRTSTPHVYA
AGDCTDQPQFVYVAAAAGTRAAINMTGGEAAIDLSVMPAVVFTDPQVATVGYSEAQGHHDGIETDSRLLTLDNVPRALAN
FDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFSKDVTQLSCCA
G
>Mature_560_residues
TDLKITGMTCDSCAAHVKEALEKVPGVFSAVVSYAKGTAQLATELGTSPDALTAAVAGLGYKATLADAPTAEKRGGLLDK
ARGWLSGGDKSVGDGGKLHIAVIGSGGAAMAAALKAAEQGAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESP
FDDGIEATVPAIDRRELLAQQQARVDELRHAKYEGILDSNPAINVLQGEARFKDGQSLAVGLNDGGERAVVFDRCLVATG
ASAAVPPIPGLKDTPYWTSIEALVSDTIPQRLAVIGSSVVAVELAQAFARLGSQVTILARSTLFFREDPAIGEAVTAAFR
AEGIKVLEHTQASHVAYADGEFLLTTGHGEVRADKLLVATGRAPNTHSLALEAAGVTVNAQGAIVIDKFMRTSTPHVYAA
GDCTDQPQFVYVAAAAGTRAAINMTGGEAAIDLSVMPAVVFTDPQVATVGYSEAQGHHDGIETDSRLLTLDNVPRALANF
DTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFSKDVTQLSCCAG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=30.168776371308, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI50301238, Length=445, Percent_Identity=27.6404494382022, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI22035672, Length=445, Percent_Identity=28.5393258426966, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI148277065, Length=444, Percent_Identity=26.1261261261261, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI148277071, Length=444, Percent_Identity=26.3513513513513, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI33519430, Length=444, Percent_Identity=26.3513513513513, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI33519428, Length=444, Percent_Identity=26.3513513513513, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI33519426, Length=444, Percent_Identity=26.3513513513513, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=30.4635761589404, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786307, Length=470, Percent_Identity=28.936170212766, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1789915, Length=417, Percent_Identity=32.6139088729017, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=25.219298245614, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=27.5488069414317, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71983419, Length=353, Percent_Identity=32.2946175637394, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=353, Percent_Identity=32.0113314447592, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17557007, Length=463, Percent_Identity=28.2937365010799, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17559934, Length=257, Percent_Identity=25.2918287937743, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=29.0322580645161, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=373, Percent_Identity=28.686327077748, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=25.4736842105263, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21358499, Length=483, Percent_Identity=30.6418219461698, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17737741, Length=494, Percent_Identity=28.1376518218623, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=28.3673469387755, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=28.3673469387755, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=28.3673469387755, Blast_Score=129, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24639257, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281359715, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281359713, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24639250, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI18543267, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24639252, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 58399; Mature: 58268

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLKITGMTCDSCAAHVKEALEKVPGVFSAVVSYAKGTAQLATELGTSPDALTAAVAGL
CCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHCC
GYKATLADAPTAEKRGGLLDKARGWLSGGDKSVGDGGKLHIAVIGSGGAAMAAALKAAEQ
CCEEEECCCCCHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHC
GAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDDGIEATVPAIDRRELLA
CCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
QQQARVDELRHAKYEGILDSNPAINVLQGEARFKDGQSLAVGLNDGGERAVVFDRCLVAT
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHHC
GASAAVPPIPGLKDTPYWTSIEALVSDTIPQRLAVIGSSVVAVELAQAFARLGSQVTILA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEE
RSTLFFREDPAIGEAVTAAFRAEGIKVLEHTQASHVAYADGEFLLTTGHGEVRADKLLVA
EEEEEEECCCCHHHHHHHHHHHCCCCEEHHCCCCEEEEECCCEEEECCCCCEEECEEEEE
TGRAPNTHSLALEAAGVTVNAQGAIVIDKFMRTSTPHVYAAGDCTDQPQFVYVAAAAGTR
ECCCCCCCEEEEEECCEEEECCCCEEEEHHHHCCCCEEEECCCCCCCCCEEEEEECCCCE
AAINMTGGEAAIDLSVMPAVVFTDPQVATVGYSEAQGHHDGIETDSRLLTLDNVPRALAN
EEEEECCCCEEEEEEEECEEEECCCCEEEECCHHCCCCCCCCCCCCEEEEECCCCHHHHC
FDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVE
CCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GLKLAAQTFSKDVTQLSCCAG
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDLKITGMTCDSCAAHVKEALEKVPGVFSAVVSYAKGTAQLATELGTSPDALTAAVAGL
CCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHCC
GYKATLADAPTAEKRGGLLDKARGWLSGGDKSVGDGGKLHIAVIGSGGAAMAAALKAAEQ
CCEEEECCCCCHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHC
GAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDDGIEATVPAIDRRELLA
CCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
QQQARVDELRHAKYEGILDSNPAINVLQGEARFKDGQSLAVGLNDGGERAVVFDRCLVAT
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHHC
GASAAVPPIPGLKDTPYWTSIEALVSDTIPQRLAVIGSSVVAVELAQAFARLGSQVTILA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEE
RSTLFFREDPAIGEAVTAAFRAEGIKVLEHTQASHVAYADGEFLLTTGHGEVRADKLLVA
EEEEEEECCCCHHHHHHHHHHHCCCCEEHHCCCCEEEEECCCEEEECCCCCEEECEEEEE
TGRAPNTHSLALEAAGVTVNAQGAIVIDKFMRTSTPHVYAAGDCTDQPQFVYVAAAAGTR
ECCCCCCCEEEEEECCEEEECCCCEEEEHHHHCCCCEEEECCCCCCCCCEEEEEECCCCE
AAINMTGGEAAIDLSVMPAVVFTDPQVATVGYSEAQGHHDGIETDSRLLTLDNVPRALAN
EEEEECCCCEEEEEEEECEEEECCCCEEEECCHHCCCCCCCCCCCCEEEEECCCCHHHHC
FDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVE
CCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GLKLAAQTFSKDVTQLSCCAG
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8302940 [H]