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The map label for this gene is pccB [H]

Identifier: 91788037

GI number: 91788037

Start: 2257439

End: 2258971

Strand: Direct

Name: pccB [H]

Synonym: Bpro_2164

Alternate gene names: 91788037

Gene position: 2257439-2258971 (Clockwise)

Preceding gene: 91788036

Following gene: 91788038

Centisome position: 43.41

GC content: 61.77

Gene sequence:

>1533_bases
ATGCAAGACATCCTCGAACAACTCGAAAAAAAGCGTGCTGCAGCCCGCCTCGGCGGTGGCCAGAAGCGCATTGACGCCCA
GCATGGCAAGGGTAAGCTCACCGCGCGTGAGCGCCTGGAGCTGCTGCTTGACGAAGGCACCTTTGAAGAATGGGACATGT
TTGTCGAGCACCGCTGCACCGACTTCGGCATGGCCGACAACAAGATTCCCGGCGACGGCGTGGTCACCGGCTACGGCATG
ATCAACGGCCGGCTGGTGTTTGTCTTCAGCCAGGACTTCACGGTGTTCGGCGGTGCGCTCAGCGAAGCCCATGCCGAGAA
AATCTGCAAGGTGATGGACCAGGCCATGAAGGTCGGCGCGCCGGTGATTGGCCTGAACGACTCGGGTGGTGCGCGCATCC
AGGAAGGTGTGGCTTCGCTGGGCGGCTATGCCGACGTGTTCCAGCGCAACGTGATGGCCAGCGGCGTGATCCCGCAGATC
AGCATGATCATGGGGCCCAGCGCCGGCGGCGCGGTGTATTCGCCCGCCATGACCGACTTCATCTTCATGGTCAAGGACAG
CTCCTACATGTTTGTCACCGGCCCCGAGGTGGTGAAGACAGTCACGCACGAAGAGGTGAGCGCCGAGGAGTTGGGCGGTG
CCATCACGCACACCACCCGCAGTGGCGTGGCCGACCTCGCCTTCGAGAATGACGTCGAAGCGCTGTTGATGCTGCGCCGC
CTCTACAACTACCTGCCGCTGAACAACCGTGAGAAAGCCCCGGCGCGCCCCAGCGCCGACCCGGCCGGGCGCATGGACCT
GAGCCTGGACACGCTGGTGCCCGAGAACCCCAACAAGCCGTATGACATGAAGGAGCTGATCGTCAAGACAGTGGACGACG
GCGATTTCTTCGAGATCCAGCCCGAGTACGCCAAGAACATCGTCATTGGTTTTGCGCGCATGGAAGGCCAGTCGGTGGGC
ATCGTGGCCAACCAGCCGCTGGTGCTGGCAGGCTGCCTCGATATCAAGAGCTCGATCAAGGCCGCGCGCTTTGTGCGGTT
TTGCGATGCCTTCAATATTCCGGTAATCACCTTTGTCGACGTGCCCGGCTTCATGCCCGGTACCAGCCAGGAATACGGCG
GCATCATCAAGCACGGCGCCAAGCTGCTGTACGCCTATGCCGAATGCACCGTACCCAAGATCACCGTCATCACGCGCAAG
GCTTATGGCGGCGCCTACGACGTGATGAGTTCCAAACACCTGCGCGGCGACGTCAACTTTGCCTGGCCCAACGCCGAGAT
CGCCGTGATGGGCGCCAAGGGCGCGGTGGAGATCATCTTTCGTGAAGACAAGGGTGACCCGGCCAAGCTGGCGGCCAAGG
AGGCCGAATACAAGGCCCGCTTCGCCAACCCCTTTGTCGCGGGCGCTCGCGGCTTCATCGACGACGTGATCCTGCCGCAT
GAAACGCGTAGACGCATTTGCCGCTCGCTGGTGATGCTGCGTGACAAGAAGATTGAGAACCCGTGGCGCAAGCACGGAAA
CATTCCGTTGTGA

Upstream 100 bases:

>100_bases
CCCGCCTCAACCGCAGCACGGAATCTGCTTGCAGCCCAATTGGGGCGTGCGCCGGCGGCCATCAAATAAAGAGCATTTCA
AAGGGTACAGAAAGTAAATC

Downstream 100 bases:

>100_bases
TGCAAATTGCCAAACCCATGAGCGTTCCTTTGACATGGCTAGCCTGAGCACCTGGCTTGACGCCAAACTGGCCGCAGGGT
CCGTCAAGCAACATCGTCAA

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQDILEQLEKKRAAARLGGGQKRIDAQHGKGKLTARERLELLLDEGTFEEWDMFVEHRCTDFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHTTRSGVADLAFENDVEALLMLRR
LYNYLPLNNREKAPARPSADPAGRMDLSLDTLVPENPNKPYDMKELIVKTVDDGDFFEIQPEYAKNIVIGFARMEGQSVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAKEAEYKARFANPFVAGARGFIDDVILPH
ETRRRICRSLVMLRDKKIENPWRKHGNIPL

Sequences:

>Translated_510_residues
MQDILEQLEKKRAAARLGGGQKRIDAQHGKGKLTARERLELLLDEGTFEEWDMFVEHRCTDFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHTTRSGVADLAFENDVEALLMLRR
LYNYLPLNNREKAPARPSADPAGRMDLSLDTLVPENPNKPYDMKELIVKTVDDGDFFEIQPEYAKNIVIGFARMEGQSVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAKEAEYKARFANPFVAGARGFIDDVILPH
ETRRRICRSLVMLRDKKIENPWRKHGNIPL
>Mature_510_residues
MQDILEQLEKKRAAARLGGGQKRIDAQHGKGKLTARERLELLLDEGTFEEWDMFVEHRCTDFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHTTRSGVADLAFENDVEALLMLRR
LYNYLPLNNREKAPARPSADPAGRMDLSLDTLVPENPNKPYDMKELIVKTVDDGDFFEIQPEYAKNIVIGFARMEGQSVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAKEAEYKARFANPFVAGARGFIDDVILPH
ETRRRICRSLVMLRDKKIENPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=70.6114398422091, Blast_Score=748, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=67.9316888045541, Blast_Score=734, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=507, Percent_Identity=33.9250493096647, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI38679960, Length=392, Percent_Identity=25.2551020408163, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI38679971, Length=392, Percent_Identity=25.2551020408163, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI38679974, Length=392, Percent_Identity=25.2551020408163, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679977, Length=392, Percent_Identity=25.2551020408163, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679967, Length=392, Percent_Identity=25.2551020408163, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI134142062, Length=398, Percent_Identity=23.1155778894472, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=68.6390532544379, Blast_Score=744, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=68.6390532544379, Blast_Score=743, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=501, Percent_Identity=33.5329341317365, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24586065, Length=513, Percent_Identity=34.1130604288499, Blast_Score=239, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55813; Mature: 55813

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDILEQLEKKRAAARLGGGQKRIDAQHGKGKLTARERLELLLDEGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
DFGMADNKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
CCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQISMIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHTTRSGVADLAFENDVEALLMLRR
EEEEECCCEEEEECHHHHHHHHHHHCCHHHHCCEEEECCCCCCHHHHHCCCHHHHHHHHH
LYNYLPLNNREKAPARPSADPAGRMDLSLDTLVPENPNKPYDMKELIVKTVDDGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEC
PEYAKNIVIGFARMEGQSVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVD
HHHHCCEEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNF
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCEE
AWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAKEAEYKARFANPFVAGARGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCCCC
ETRRRICRSLVMLRDKKIENPWRKHGNIPL
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure
MQDILEQLEKKRAAARLGGGQKRIDAQHGKGKLTARERLELLLDEGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
DFGMADNKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
CCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQISMIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHTTRSGVADLAFENDVEALLMLRR
EEEEECCCEEEEECHHHHHHHHHHHCCHHHHCCEEEECCCCCCHHHHHCCCHHHHHHHHH
LYNYLPLNNREKAPARPSADPAGRMDLSLDTLVPENPNKPYDMKELIVKTVDDGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEC
PEYAKNIVIGFARMEGQSVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVD
HHHHCCEEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNF
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCEE
AWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAKEAEYKARFANPFVAGARGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCCCC
ETRRRICRSLVMLRDKKIENPWRKHGNIPL
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]