Click here to switch to the map view.

The map label for this gene is ilvR [H]

Identifier: 91787929

GI number: 91787929

Start: 2134543

End: 2135514

Strand: Direct

Name: ilvR [H]

Synonym: Bpro_2053

Alternate gene names: 91787929

Gene position: 2134543-2135514 (Clockwise)

Preceding gene: 91787927

Following gene: 91787935

Centisome position: 41.05

GC content: 66.26

Gene sequence:

>972_bases
ATGACAGATTCGGTTCATTCCGCTCATTCCTCAGCTCATTTCGTTCCTGCGGGGGGTGGTGATCCGCGCAATCCTCCGCT
GATCGAGCTTCGCCTGTGGCGCCAGTTTGCAGCTGTTGCCGACGAGCTTCATTTCGGCCGCGCCGCGCTGCGCCTGAACA
TGACCCAGCCGCCGCTGACGCAGGCCATTGCCCATCTGGAGGCCCTGCTTGGCCTGAAGCTGTTCGACCGCACCAAGCGC
AGCGTGCAGCTGACAGCGGCGGGGGCCGCGCTGCTGCCGGAGGCGCGCGACCTGCTCGCGCGTGCCCAAGCCTTGCCCGT
CTATGCGCGCGCCACTGCGGATGGCGAAGCAGGGCGCTTGCGGCTGGCCTTTGTGTCAACAGTGGGCTTTGATTTGCTGC
CGGGCTGGGTCCGGACCTTTCGTGAGCGCTATCCCAAGGTGCAGCTGGAGCTGATTGAAGCCACCGGCGATGTGCAGCTC
CAGGCCCTGGAGCGCGGCGAGATCGACGCCGGCTTCATGTTGCACTCGCCGGGCTTTGCGCCTCCCGGCCTGACCTGCCG
GCGCATCTCGCAGGATCCGCTGGTGCTGGCCGTGCCGGAGCAAAGCGTGCTGGTCGGCAAGTCCGGGCTGGTGCTGCAGG
ACTTGCTGGAGCAGCCGCTGGTGATTTTTCCGCGGCACATCCTGCCTTCGCTCTATGACGCGATTTTTGCCATGTACCAC
GCGGCTGGCCACCTGCCGCGCGTGGCCCAGGAAGCCATCCAGATGCAAACCATCGTCAACCTGGTATCGGCAGGCCTGGG
CGTGGCCTGGGTGCCCGACAGTGTGCGGCAGTTCCAGCGGCCGGGCGTGGTGTACCGGGAACTCAAAAGGGGCAAGGGGC
AGGTGGTGCCGGGCTGTGAGACGAGCCTGGTGTGGGCCGCCGGGGCCGCCAGTCCTGCATTGCAGCGATTCATGGCGTTT
GCACCCGGTTGA

Upstream 100 bases:

>100_bases
GGCGGATGCATGTGGGATATTTTTACCGGAAAGCCGAGTATGCGTGTTTTGACTGATTCTTTCCAATCCATTATTTAGAC
TGTATTAATATGTGCAGCAT

Downstream 100 bases:

>100_bases
CGGCGTTCGCCGGGCGGGTGGCGTGGGCCGCGTGGGTGCGGTCCTGCGCGCCTATTTCCAGGCAAACGCCGGCTGCTCGA
AATGCGCCACGCGGGTGGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTDSVHSAHSSAHFVPAGGGDPRNPPLIELRLWRQFAAVADELHFGRAALRLNMTQPPLTQAIAHLEALLGLKLFDRTKR
SVQLTAAGAALLPEARDLLARAQALPVYARATADGEAGRLRLAFVSTVGFDLLPGWVRTFRERYPKVQLELIEATGDVQL
QALERGEIDAGFMLHSPGFAPPGLTCRRISQDPLVLAVPEQSVLVGKSGLVLQDLLEQPLVIFPRHILPSLYDAIFAMYH
AAGHLPRVAQEAIQMQTIVNLVSAGLGVAWVPDSVRQFQRPGVVYRELKRGKGQVVPGCETSLVWAAGAASPALQRFMAF
APG

Sequences:

>Translated_323_residues
MTDSVHSAHSSAHFVPAGGGDPRNPPLIELRLWRQFAAVADELHFGRAALRLNMTQPPLTQAIAHLEALLGLKLFDRTKR
SVQLTAAGAALLPEARDLLARAQALPVYARATADGEAGRLRLAFVSTVGFDLLPGWVRTFRERYPKVQLELIEATGDVQL
QALERGEIDAGFMLHSPGFAPPGLTCRRISQDPLVLAVPEQSVLVGKSGLVLQDLLEQPLVIFPRHILPSLYDAIFAMYH
AAGHLPRVAQEAIQMQTIVNLVSAGLGVAWVPDSVRQFQRPGVVYRELKRGKGQVVPGCETSLVWAAGAASPALQRFMAF
APG
>Mature_322_residues
TDSVHSAHSSAHFVPAGGGDPRNPPLIELRLWRQFAAVADELHFGRAALRLNMTQPPLTQAIAHLEALLGLKLFDRTKRS
VQLTAAGAALLPEARDLLARAQALPVYARATADGEAGRLRLAFVSTVGFDLLPGWVRTFRERYPKVQLELIEATGDVQLQ
ALERGEIDAGFMLHSPGFAPPGLTCRRISQDPLVLAVPEQSVLVGKSGLVLQDLLEQPLVIFPRHILPSLYDAIFAMYHA
AGHLPRVAQEAIQMQTIVNLVSAGLGVAWVPDSVRQFQRPGVVYRELKRGKGQVVPGCETSLVWAAGAASPALQRFMAFA
PG

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=38.7351778656126, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI2367136, Length=293, Percent_Identity=36.1774744027304, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=32.0819112627986, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790399, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=28.4552845528455, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=32.3404255319149, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=28.0487804878049, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=29.6116504854369, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787530, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082132, Length=303, Percent_Identity=26.4026402640264, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788296, Length=256, Percent_Identity=28.125, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787601, Length=142, Percent_Identity=27.4647887323944, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=255, Percent_Identity=25.4901960784314, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790262, Length=260, Percent_Identity=25, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34999; Mature: 34868

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSVHSAHSSAHFVPAGGGDPRNPPLIELRLWRQFAAVADELHFGRAALRLNMTQPPLT
CCCCHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
QAIAHLEALLGLKLFDRTKRSVQLTAAGAALLPEARDLLARAQALPVYARATADGEAGRL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEE
RLAFVSTVGFDLLPGWVRTFRERYPKVQLELIEATGDVQLQALERGEIDAGFMLHSPGFA
EEEEEHHHCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCEEEECCCCC
PPGLTCRRISQDPLVLAVPEQSVLVGKSGLVLQDLLEQPLVIFPRHILPSLYDAIFAMYH
CCCCEEEECCCCCEEEEECCCCEEECCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
AAGHLPRVAQEAIQMQTIVNLVSAGLGVAWVPDSVRQFQRPGVVYRELKRGKGQVVPGCE
HHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCHHHHHHHCCCCCCCCCCC
TSLVWAAGAASPALQRFMAFAPG
CCEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TDSVHSAHSSAHFVPAGGGDPRNPPLIELRLWRQFAAVADELHFGRAALRLNMTQPPLT
CCCHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
QAIAHLEALLGLKLFDRTKRSVQLTAAGAALLPEARDLLARAQALPVYARATADGEAGRL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEE
RLAFVSTVGFDLLPGWVRTFRERYPKVQLELIEATGDVQLQALERGEIDAGFMLHSPGFA
EEEEEHHHCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCEEEECCCCC
PPGLTCRRISQDPLVLAVPEQSVLVGKSGLVLQDLLEQPLVIFPRHILPSLYDAIFAMYH
CCCCEEEECCCCCEEEEECCCCEEECCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
AAGHLPRVAQEAIQMQTIVNLVSAGLGVAWVPDSVRQFQRPGVVYRELKRGKGQVVPGCE
HHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCHHHHHHHCCCCCCCCCCC
TSLVWAAGAASPALQRFMAFAPG
CCEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]