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The map label for this gene is lon [H]

Identifier: 91787908

GI number: 91787908

Start: 2106179

End: 2108608

Strand: Direct

Name: lon [H]

Synonym: Bpro_2032

Alternate gene names: 91787908

Gene position: 2106179-2108608 (Clockwise)

Preceding gene: 91787907

Following gene: 91787909

Centisome position: 40.5

GC content: 57.74

Gene sequence:

>2430_bases
ATGTCCGGACAAACTTCATTGCCTTCCACCCCCATCGATTTGCCACTGCTGCCTCTGCGGGACGTGGTGGTCTTTCCCCA
CATGGTCATTCCGCTGTTTGTGGGGCGGCCCAAGAGCATCAAGGCGCTTGAGTCGGCCATGGAGGCCGAACGCCGCATCA
TGCTGGTGGCCCAAAAGGCCGCAGCCAAGGACGAGCCCTCGGTCGAGGACATGTTCGAGGTGGGCTGTGTGGCCACTATC
CTGCAGTTGCTCAAGCTGCCTGACGGTACGGTCAAGGTCCTGGTGGAAGGGCAGCAGCGCGCCAGGGTCAATAAAATCGA
GGACGGCGAACAGCACTTCACCGCCAATGTCACCCCTGTTGAGCCCACCGTGGTGGTTGTGGGTGACAAGGGCAGCGAGA
TTGAAGCCTTGCGCCGCGCCGTGATGCAGCAGTTTGATCATTACGTCAAACTCAACAAGAAAATTCCGCCGGAAATCCTC
ACCTCGATTTCCAGCATCGATGACGCGGGCCGGCTGGCCGATACGATCGCGGCTCACCTGCCGCTCAAACTCGATGCCAA
GCAGATCATTCTGGATCTCGACAACGTCAAGTTGCGGCTCGAAAATCTTTACGAGCAGCTTGAGCGCGAAGTGGACATCC
TCAATGTGGACAAAAAAATCCGTGGCCGTGTCAAGCGCCAGATGGAAAAGAACCAGCGGGACTTCTACCTCAATGAGCAG
GTGAAAGCCATCCAGAAGGAACTGGGTGAAGGCGAAGAAGGCGCTGACATCGAAGAGATCGAGAAGAAGATCAAGTCGGC
CAAGATGCCGCAGGATGCACGCAAAAAAGCCGAAAGCGAGCTCAAGAAACTCAAGCTGATGTCACCGATGTCGGCTGAAG
CGACTGTGGTGCGTACCTACATCGATGTACTGACCGGTTTGCCGTGGAGCAAAAAGACCAAGATCAAGCACGATCTGGTC
AACGCCGAGAATGTGCTCAATGAAGACCACTATGGCCTTGAAAAAGTCAAGGACCGCATTGTGGAATACCTCGCGGTGCA
ACAGCGGGTTGACAAGCTCAAGGCCCCGATTCTTTGCCTGGTGGGCCCTCCTGGTGTGGGCAAGACTTCGTTGGGCCAGT
CCATCGCCAAAGCGACGGGGCGCAAATACGTACGCATGGCGCTGGGCGGCATGCGTGATGAGGCGGAAATTCGTGGGCAC
CGCCGTACCTACATTGGCGCCTTGCCCGGCAAGGTGCTGCAAAGCCTGACCAAGGCGGGTACCCGCAACCCACTGTTCCT
GCTGGATGAGATCGACAAGCTGGGCACCGACTTTCGGGGGGATCCGTCAAGCGCCTTGCTGGAAGTGCTCGATCCTGAAC
AGAACCACACCTTCGGCGACCATTACGTGGAGGTCGATTTCGACCTGAGCGACGTGATGTTTGTGGCAACGTCAAACTCG
ATGAATATTCCTCCGGCCTTGCTGGACCGCATGGAAGTGATCCGGCTTGCAGGCTACACGGAAGACGAGAAAACCAGCAT
TGCGATGCGCTATCTGCTGCCCAAGCAGCTGAAGAACAATGGTGTCAAGGAGGGCGAGCTGGAAGTGACGGAGCAGGCCA
TACGCGACATCGTGCGTTACTACACACGGGAGGCCGGTGTGCGTTCGCTGGAGCGGGATCTCTCCAAAATCTGCCGCAAG
GTGGTCAAGGGCATTCAGCTCAAGAAAATGATGGCCAAGGTCGTGGTGGAGCCCGACAACCTGAACGACTTCCTGGGCGT
GCGCAAATTCGACTACGGCCGTGCCGAACAGCAGAATCAGGTTGGCCAGGTGGTCGGCCTGGCCTGGACGGAAGTCGGTG
GCGATTTGTTGACGATTGAGGCGGCCATCATGCCGGGCAAAGGCGTGATCACGCGTACTGGCTTGTTGGGCGACGTGATG
AAGGAATCGGTGGAGGCCGCGCGTACGGTGGTTCGCAGCCGCTCCAGAATGCTGGGCATCAAGGATGAGATGTTCGAGAA
GCGCGACATCCATATTCACGTGCCGGATGGTGCGACGCCCAAGGACGGGCCGAGCGCTGGCGCTGCCATGACCACGGCCT
TTGTCTCGGCCCTCACCGGCATTCCGGTGCGCGGCGATGTTGCGATGACGGGTGAGATCACTTTGCGTGGTGAAGTGACC
GCCATTGGTGGCTTGAAGGAAAAATTGCTGGCTGCTTTGCGCGGTGGCATCAAGACGGTATTGATCCCGGAAGAAAATGC
CAAGGACCTGCAGGAAATTCCGGACAACGTGAAGAGCGGTCTGAACATCGTGCCGGTGAAGTGGATTGATCAGGTGCTGC
AGGTCGCACTGGAGCGCAATCCTGTTCCGTTGAGTGATGAAGAAGTCGCTGTTGCCGCTGCGGCCGCTGTCGCTACACCT
GTCGAAGTTGCAGGCACTGTGAAGCATTGA

Upstream 100 bases:

>100_bases
GCGCAAGGCTTGAAAAGCAATTCTTGCGCCCCACTTCTGGGTTGACTACGCTACTCCTGGCCATGAAACTGGTCGCCACG
GCTTACGTTTAAGGTTTTAT

Downstream 100 bases:

>100_bases
AGCAAAACAGAAGCAAACTTTTTTTCGATTTGTTGAAAAGCCTGAAAAGTTACGCTATAATTTGAGGCTGTTATCGCGGG
AGTAGCTCAGTTGGTAGAGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MSGQTSLPSTPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALESAMEAERRIMLVAQKAAAKDEPSVEDMFEVGCVATI
LQLLKLPDGTVKVLVEGQQRARVNKIEDGEQHFTANVTPVEPTVVVVGDKGSEIEALRRAVMQQFDHYVKLNKKIPPEIL
TSISSIDDAGRLADTIAAHLPLKLDAKQIILDLDNVKLRLENLYEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQ
VKAIQKELGEGEEGADIEEIEKKIKSAKMPQDARKKAESELKKLKLMSPMSAEATVVRTYIDVLTGLPWSKKTKIKHDLV
NAENVLNEDHYGLEKVKDRIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGH
RRTYIGALPGKVLQSLTKAGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATSNS
MNIPPALLDRMEVIRLAGYTEDEKTSIAMRYLLPKQLKNNGVKEGELEVTEQAIRDIVRYYTREAGVRSLERDLSKICRK
VVKGIQLKKMMAKVVVEPDNLNDFLGVRKFDYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAAIMPGKGVITRTGLLGDVM
KESVEAARTVVRSRSRMLGIKDEMFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGEVT
AIGGLKEKLLAALRGGIKTVLIPEENAKDLQEIPDNVKSGLNIVPVKWIDQVLQVALERNPVPLSDEEVAVAAAAAVATP
VEVAGTVKH

Sequences:

>Translated_809_residues
MSGQTSLPSTPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALESAMEAERRIMLVAQKAAAKDEPSVEDMFEVGCVATI
LQLLKLPDGTVKVLVEGQQRARVNKIEDGEQHFTANVTPVEPTVVVVGDKGSEIEALRRAVMQQFDHYVKLNKKIPPEIL
TSISSIDDAGRLADTIAAHLPLKLDAKQIILDLDNVKLRLENLYEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQ
VKAIQKELGEGEEGADIEEIEKKIKSAKMPQDARKKAESELKKLKLMSPMSAEATVVRTYIDVLTGLPWSKKTKIKHDLV
NAENVLNEDHYGLEKVKDRIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGH
RRTYIGALPGKVLQSLTKAGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATSNS
MNIPPALLDRMEVIRLAGYTEDEKTSIAMRYLLPKQLKNNGVKEGELEVTEQAIRDIVRYYTREAGVRSLERDLSKICRK
VVKGIQLKKMMAKVVVEPDNLNDFLGVRKFDYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAAIMPGKGVITRTGLLGDVM
KESVEAARTVVRSRSRMLGIKDEMFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGEVT
AIGGLKEKLLAALRGGIKTVLIPEENAKDLQEIPDNVKSGLNIVPVKWIDQVLQVALERNPVPLSDEEVAVAAAAAVATP
VEVAGTVKH
>Mature_808_residues
SGQTSLPSTPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALESAMEAERRIMLVAQKAAAKDEPSVEDMFEVGCVATIL
QLLKLPDGTVKVLVEGQQRARVNKIEDGEQHFTANVTPVEPTVVVVGDKGSEIEALRRAVMQQFDHYVKLNKKIPPEILT
SISSIDDAGRLADTIAAHLPLKLDAKQIILDLDNVKLRLENLYEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQV
KAIQKELGEGEEGADIEEIEKKIKSAKMPQDARKKAESELKKLKLMSPMSAEATVVRTYIDVLTGLPWSKKTKIKHDLVN
AENVLNEDHYGLEKVKDRIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHR
RTYIGALPGKVLQSLTKAGTRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATSNSM
NIPPALLDRMEVIRLAGYTEDEKTSIAMRYLLPKQLKNNGVKEGELEVTEQAIRDIVRYYTREAGVRSLERDLSKICRKV
VKGIQLKKMMAKVVVEPDNLNDFLGVRKFDYGRAEQQNQVGQVVGLAWTEVGGDLLTIEAAIMPGKGVITRTGLLGDVMK
ESVEAARTVVRSRSRMLGIKDEMFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGEVTA
IGGLKEKLLAALRGGIKTVLIPEENAKDLQEIPDNVKSGLNIVPVKWIDQVLQVALERNPVPLSDEEVAVAAAAAVATPV
EVAGTVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.2127659574468, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI21396489, Length=661, Percent_Identity=39.0317700453858, Blast_Score=474, Evalue=1e-133,
Organism=Escherichia coli, GI1786643, Length=775, Percent_Identity=66.9677419354839, Blast_Score=1053, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=696, Percent_Identity=38.3620689655172, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17556486, Length=541, Percent_Identity=38.8170055452865, Blast_Score=421, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=711, Percent_Identity=40.9282700421941, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=576, Percent_Identity=43.9236111111111, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=42.5806451612903, Blast_Score=484, Evalue=1e-136,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89175; Mature: 89043

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQTSLPSTPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALESAMEAERRIMLVAQKA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHH
AAKDEPSVEDMFEVGCVATILQLLKLPDGTVKVLVEGQQRARVNKIEDGEQHFTANVTPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCHHEEECCCCC
EPTVVVVGDKGSEIEALRRAVMQQFDHYVKLNKKIPPEILTSISSIDDAGRLADTIAAHL
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHC
PLKLDAKQIILDLDNVKLRLENLYEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQ
CCEECHHHHHEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
VKAIQKELGEGEEGADIEEIEKKIKSAKMPQDARKKAESELKKLKLMSPMSAEATVVRTY
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IDVLTGLPWSKKTKIKHDLVNAENVLNEDHYGLEKVKDRIVEYLAVQQRVDKLKAPILCL
HHHHHCCCCCCCCHHHHHHHCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGALPGKVLQSLTKAG
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCCHHHHHHHHHCC
TRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATSNS
CCCCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCC
MNIPPALLDRMEVIRLAGYTEDEKTSIAMRYLLPKQLKNNGVKEGELEVTEQAIRDIVRY
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YTREAGVRSLERDLSKICRKVVKGIQLKKMMAKVVVEPDNLNDFLGVRKFDYGRAEQQNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHH
VGQVVGLAWTEVGGDLLTIEAAIMPGKGVITRTGLLGDVMKESVEAARTVVRSRSRMLGI
HHHHHHHHHHHCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
KDEMFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGEVT
HHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEE
AIGGLKEKLLAALRGGIKTVLIPEENAKDLQEIPDNVKSGLNIVPVKWIDQVLQVALERN
ECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHCC
PVPLSDEEVAVAAAAAVATPVEVAGTVKH
CCCCCCCHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure 
SGQTSLPSTPIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALESAMEAERRIMLVAQKA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHH
AAKDEPSVEDMFEVGCVATILQLLKLPDGTVKVLVEGQQRARVNKIEDGEQHFTANVTPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCHHEEECCCCC
EPTVVVVGDKGSEIEALRRAVMQQFDHYVKLNKKIPPEILTSISSIDDAGRLADTIAAHL
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHC
PLKLDAKQIILDLDNVKLRLENLYEQLEREVDILNVDKKIRGRVKRQMEKNQRDFYLNEQ
CCEECHHHHHEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
VKAIQKELGEGEEGADIEEIEKKIKSAKMPQDARKKAESELKKLKLMSPMSAEATVVRTY
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IDVLTGLPWSKKTKIKHDLVNAENVLNEDHYGLEKVKDRIVEYLAVQQRVDKLKAPILCL
HHHHHCCCCCCCCHHHHHHHCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGALPGKVLQSLTKAG
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCCHHHHHHHHHCC
TRNPLFLLDEIDKLGTDFRGDPSSALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATSNS
CCCCEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCC
MNIPPALLDRMEVIRLAGYTEDEKTSIAMRYLLPKQLKNNGVKEGELEVTEQAIRDIVRY
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YTREAGVRSLERDLSKICRKVVKGIQLKKMMAKVVVEPDNLNDFLGVRKFDYGRAEQQNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHH
VGQVVGLAWTEVGGDLLTIEAAIMPGKGVITRTGLLGDVMKESVEAARTVVRSRSRMLGI
HHHHHHHHHHHCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
KDEMFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGEVT
HHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEE
AIGGLKEKLLAALRGGIKTVLIPEENAKDLQEIPDNVKSGLNIVPVKWIDQVLQVALERN
ECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHCC
PVPLSDEEVAVAAAAAVATPVEVAGTVKH
CCCCCCCHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]