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The map label for this gene is dxs

Identifier: 91787629

GI number: 91787629

Start: 1806533

End: 1808440

Strand: Direct

Name: dxs

Synonym: Bpro_1747

Alternate gene names: 91787629

Gene position: 1806533-1808440 (Clockwise)

Preceding gene: 91787628

Following gene: 91787630

Centisome position: 34.74

GC content: 64.41

Gene sequence:

>1908_bases
ATGTACCCATTGCTCGAAACCATCAACAGCCCCGCAGACCTGCGCAGGCTGCCCCGCGCCCAGCTCAAGGCCCTGGCTGA
CGAGTTGCGAGCCTTCGTGCTCGACAGCGTTTCCAAGACTGGCGGGCATCTGAGCTCCAACCTTGGCACGGTGGAACTGA
CGGTGGCGCTGCACTATGTTTTCAACACGCCCGAGGATCGGCTGGTCTGGGATGTGGGCCACCAGACCTATCCGCACAAA
ATCCTCACGGGGCGGCGCGATCGCATGGGCAGCCTGCGCCAGTTCGGCGGTTTGTCGGGTTTTCCGCGCCGGGACGAAAG
CCCGTACGACACCTTCGGCACCGCGCATTCCTCGACCTCGATTTCTGCCGCGCTGGGCATGGCGCTGGCGGCCCACCAGC
AGGGGGAAGACCGCCATGCGGTCGCCATCATCGGTGACGGCGCGATGAGCGCAGGCATGGCCTTTGAAGCTCTGAACAAC
GCGGGCGTGCATGACGACTGCAAGTTGCTGGTGGTGCTCAACGACAACGACATGAGCATCAGCCCGCCCGTCGGGGCCCT
GAACCGCTACCTGGCGCAATTGATGAGCGGCCGCTTTTATGCATCGGCTAAAAATGTCGGCAAGCAGGTGCTCAGGGTGG
CGCCGCCGCTGCTTGAACTGGCCAAACGCCTGGAGGCGCATGCCAAGGGCATGGTGGTGCCCGCCACGCTGTTTGAAAAT
TTCGGATTCAATTACATCGGACCGATTGACGGCCATGATCTGGAGTCCCTGATTCCCACGCTGGAAAACATCAAGCACCT
CAAGGGCCCGCAGTTTCTGCACGTCGTCACCAAGAAAGGCCAGGGGTACAAGCTGGCCGAAGCCGACCCGGTGGCCTACC
ACGGCCCCGGCAAGTTTGACCCGGCCATGGGTCTGCAAAAATCCAGCGCGCCTGCCAAGCGAACCTTCACCCAGGTGTTT
GGCCAGTGGTTGTGCGACATGGCGGAGCAGGACAAGCGCCTGGTCGGCATTACGCCCGCCATGCGGGAGGGCTCGGGCAT
GGTCGAGTTTCACAAGCGCTTTCCGGGCCGCTACCACGACGTGGGCATTGCCGAGCAGCATGCGGTCACCTTTGCCGCCG
GCATGGCCTGCGAAGGGCTCAAGCCCGTGGTGGCGATTTACTCGACCTTTTTGCAGCGCGGCTATGACCAGCTGATTCAC
GATGTGGCGCTGCAAAACCTGCCGGTGGTGTTTGCGCTTGACCGCGCCGGCCTGGTCGGCGCCGACGGCGCCACGCATGC
GGGCGCCTACGACATTCCGTTTTTGCGCTGCATTCCCAACATGAGCGTGGCCTGCCCGGCCGATGAGAACGAGTGCCGCA
AACTGCTGAGTTCGGCGTTTGAGCAGAACCATCCGGTGGCCGTGCGCTATCCGCGCGGTGCGGGCGCCGGCGTCGAGCCT
GAGCCGGGCCTGCAGCCGCTGCCCTTTGGCAAGGGCGAGATTCGCCGCGAAGGTTCAGGCGTCGCGATCCTGGCGTTTGG
CACGCTGCTGTACCCGGCTCTGCAGGCGGCCGAGAAGCTGGGTGTCACCGTGGTCAACATGCGATGGGCCAAACCGCTGG
ACACCGAATTGCTGCTCAAGGTGGCGGCCAGCCATGAGGCACTGGTCACGCTGGAAGAGGGCGCCATCATGGGCGGTGCC
GGCAGTGCCGTGGGCGAAGCGCTGCAGGCCGCCGGCCTCGGCAAGCCGCTGTTGCAGCTGGGCCTGAAGGACGAATTCAT
CGAGCATGGCGACCCCGCCAAGCTGCTGGCGCTGCAAGGCCTGGACGCGGCCGGTATTGAGGCCGCCGTCATGGCGCGGT
TTGGGTCTGTGCTGCAGCCTGAAAAGTCCGGCAAGCCTGCCAAGCCGGCACTCAAGTCGGTCGCCTGA

Upstream 100 bases:

>100_bases
GGCTTGGCAACACCCATGCCTTGCATGCGTTGGCCGACATGCTGGTCAATCGCCACCACTAGGAGCCGGGGACCGGCCTC
GCCATAACAGACACACCACG

Downstream 100 bases:

>100_bases
GTTCTCACATCTCTTCACTGGTTGAATCTAGCGTCCAGTTTTCCGCAGGATGCCCTTCGATACCTCAGGGTGAACGGCGG
AGAAGGCGAACGCGAGGTTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MYPLLETINSPADLRRLPRAQLKALADELRAFVLDSVSKTGGHLSSNLGTVELTVALHYVFNTPEDRLVWDVGHQTYPHK
ILTGRRDRMGSLRQFGGLSGFPRRDESPYDTFGTAHSSTSISAALGMALAAHQQGEDRHAVAIIGDGAMSAGMAFEALNN
AGVHDDCKLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYASAKNVGKQVLRVAPPLLELAKRLEAHAKGMVVPATLFEN
FGFNYIGPIDGHDLESLIPTLENIKHLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPAMGLQKSSAPAKRTFTQVF
GQWLCDMAEQDKRLVGITPAMREGSGMVEFHKRFPGRYHDVGIAEQHAVTFAAGMACEGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVVFALDRAGLVGADGATHAGAYDIPFLRCIPNMSVACPADENECRKLLSSAFEQNHPVAVRYPRGAGAGVEP
EPGLQPLPFGKGEIRREGSGVAILAFGTLLYPALQAAEKLGVTVVNMRWAKPLDTELLLKVAASHEALVTLEEGAIMGGA
GSAVGEALQAAGLGKPLLQLGLKDEFIEHGDPAKLLALQGLDAAGIEAAVMARFGSVLQPEKSGKPAKPALKSVA

Sequences:

>Translated_635_residues
MYPLLETINSPADLRRLPRAQLKALADELRAFVLDSVSKTGGHLSSNLGTVELTVALHYVFNTPEDRLVWDVGHQTYPHK
ILTGRRDRMGSLRQFGGLSGFPRRDESPYDTFGTAHSSTSISAALGMALAAHQQGEDRHAVAIIGDGAMSAGMAFEALNN
AGVHDDCKLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYASAKNVGKQVLRVAPPLLELAKRLEAHAKGMVVPATLFEN
FGFNYIGPIDGHDLESLIPTLENIKHLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPAMGLQKSSAPAKRTFTQVF
GQWLCDMAEQDKRLVGITPAMREGSGMVEFHKRFPGRYHDVGIAEQHAVTFAAGMACEGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVVFALDRAGLVGADGATHAGAYDIPFLRCIPNMSVACPADENECRKLLSSAFEQNHPVAVRYPRGAGAGVEP
EPGLQPLPFGKGEIRREGSGVAILAFGTLLYPALQAAEKLGVTVVNMRWAKPLDTELLLKVAASHEALVTLEEGAIMGGA
GSAVGEALQAAGLGKPLLQLGLKDEFIEHGDPAKLLALQGLDAAGIEAAVMARFGSVLQPEKSGKPAKPALKSVA
>Mature_635_residues
MYPLLETINSPADLRRLPRAQLKALADELRAFVLDSVSKTGGHLSSNLGTVELTVALHYVFNTPEDRLVWDVGHQTYPHK
ILTGRRDRMGSLRQFGGLSGFPRRDESPYDTFGTAHSSTSISAALGMALAAHQQGEDRHAVAIIGDGAMSAGMAFEALNN
AGVHDDCKLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYASAKNVGKQVLRVAPPLLELAKRLEAHAKGMVVPATLFEN
FGFNYIGPIDGHDLESLIPTLENIKHLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPAMGLQKSSAPAKRTFTQVF
GQWLCDMAEQDKRLVGITPAMREGSGMVEFHKRFPGRYHDVGIAEQHAVTFAAGMACEGLKPVVAIYSTFLQRGYDQLIH
DVALQNLPVVFALDRAGLVGADGATHAGAYDIPFLRCIPNMSVACPADENECRKLLSSAFEQNHPVAVRYPRGAGAGVEP
EPGLQPLPFGKGEIRREGSGVAILAFGTLLYPALQAAEKLGVTVVNMRWAKPLDTELLLKVAASHEALVTLEEGAIMGGA
GSAVGEALQAAGLGKPLLQLGLKDEFIEHGDPAKLLALQGLDAAGIEAAVMARFGSVLQPEKSGKPAKPALKSVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=657, Percent_Identity=23.1354642313546, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4507521, Length=657, Percent_Identity=23.1354642313546, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI225637459, Length=429, Percent_Identity=24.4755244755245, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI225637463, Length=429, Percent_Identity=24.4755244755245, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI225637461, Length=429, Percent_Identity=24.4755244755245, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156564403, Length=282, Percent_Identity=26.5957446808511, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4557353, Length=230, Percent_Identity=25.2173913043478, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI34101272, Length=230, Percent_Identity=25.2173913043478, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=59.3800978792822, Blast_Score=749, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=426, Percent_Identity=26.2910798122066, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538422, Length=301, Percent_Identity=24.9169435215947, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=228, Percent_Identity=30.2631578947368, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45551847, Length=640, Percent_Identity=24.375, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550715, Length=640, Percent_Identity=24.375, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645119, Length=532, Percent_Identity=24.6240601503759, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24666278, Length=656, Percent_Identity=23.780487804878, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_POLSJ (Q12CQ9)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548581.1
- ProteinModelPortal:   Q12CQ9
- SMR:   Q12CQ9
- STRING:   Q12CQ9
- GeneID:   4015610
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1747
- NMPDR:   fig|296591.1.peg.2858
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q12CQ9
- ProtClustDB:   PRK05444
- BioCyc:   PSP296591:BPRO_1747-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67882; Mature: 67882

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLLETINSPADLRRLPRAQLKALADELRAFVLDSVSKTGGHLSSNLGTVELTVALHYV
CCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPEDRLVWDVGHQTYPHKILTGRRDRMGSLRQFGGLSGFPRRDESPYDTFGTAHSSTS
ECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMALAAHQQGEDRHAVAIIGDGAMSAGMAFEALNNAGVHDDCKLLVVLNDNDMSI
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRYLAQLMSGRFYASAKNVGKQVLRVAPPLLELAKRLEAHAKGMVVPATLFEN
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEHHHHHHH
FGFNYIGPIDGHDLESLIPTLENIKHLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFD
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCEEECCCCCCC
PAMGLQKSSAPAKRTFTQVFGQWLCDMAEQDKRLVGITPAMREGSGMVEFHKRFPGRYHD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCHHHHHHHCCCCCCC
VGIAEQHAVTFAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDRAGLVG
CCCCHHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDIPFLRCIPNMSVACPADENECRKLLSSAFEQNHPVAVRYPRGAGAGVEP
CCCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
EPGLQPLPFGKGEIRREGSGVAILAFGTLLYPALQAAEKLGVTVVNMRWAKPLDTELLLK
CCCCCCCCCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHH
VAASHEALVTLEEGAIMGGAGSAVGEALQAAGLGKPLLQLGLKDEFIEHGDPAKLLALQG
HHCCCCEEEEEECCCEECCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCHHEEEECC
LDAAGIEAAVMARFGSVLQPEKSGKPAKPALKSVA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MYPLLETINSPADLRRLPRAQLKALADELRAFVLDSVSKTGGHLSSNLGTVELTVALHYV
CCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPEDRLVWDVGHQTYPHKILTGRRDRMGSLRQFGGLSGFPRRDESPYDTFGTAHSSTS
ECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMALAAHQQGEDRHAVAIIGDGAMSAGMAFEALNNAGVHDDCKLLVVLNDNDMSI
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRYLAQLMSGRFYASAKNVGKQVLRVAPPLLELAKRLEAHAKGMVVPATLFEN
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEHHHHHHH
FGFNYIGPIDGHDLESLIPTLENIKHLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFD
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCEEECCCCCCC
PAMGLQKSSAPAKRTFTQVFGQWLCDMAEQDKRLVGITPAMREGSGMVEFHKRFPGRYHD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCHHHHHHHCCCCCCC
VGIAEQHAVTFAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDRAGLVG
CCCCHHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDIPFLRCIPNMSVACPADENECRKLLSSAFEQNHPVAVRYPRGAGAGVEP
CCCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
EPGLQPLPFGKGEIRREGSGVAILAFGTLLYPALQAAEKLGVTVVNMRWAKPLDTELLLK
CCCCCCCCCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHH
VAASHEALVTLEEGAIMGGAGSAVGEALQAAGLGKPLLQLGLKDEFIEHGDPAKLLALQG
HHCCCCEEEEEECCCEECCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCHHEEEECC
LDAAGIEAAVMARFGSVLQPEKSGKPAKPALKSVA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA