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The map label for this gene is guaD [H]

Identifier: 91787390

GI number: 91787390

Start: 1551361

End: 1552710

Strand: Direct

Name: guaD [H]

Synonym: Bpro_1496

Alternate gene names: 91787390

Gene position: 1551361-1552710 (Clockwise)

Preceding gene: 91787389

Following gene: 91787395

Centisome position: 29.83

GC content: 64.89

Gene sequence:

>1350_bases
ATGCACTGCAGGCCGCGCTGCGGTAACCTTGCGGGCATGAAAGCCTATCGCGCCAGCCTCCTGTACTTTGCCGCACCTGA
GAGCCTGCCGGGCCAGGTCACGTTCGAGCAGGATGGCCTGCTCGTGGTGGGCCCTGACGCCACGGGCCGGCAGGTGGTGC
AGGCCATCGGCAGCTACCAGCAACTCGCTTCCCAGGTGGGCAGCCAGTACCCCGGCCTGCAGGTAGAACACCTGCCGGGC
CGCATCATTGCGCCGGGCTTTGTGGACATGCACATCCACTACCCGCAGATCGACGTGATCGGCTCGCCCGCCGAGGGCCT
GCTACCCTGGCTGGAGAACTACACCTTTCCACATGAAAAACGCTTCTCATCCCCCGAATACAGTGCGGAAGCGGCTACGT
TTTTCATCGCAGAACTGCTGCGCCACGGCGTGACGACGGCGCTGGCCTTTGCGACCTCGCACCCCGAATCGGTCAACGCG
CTGCTGGGCGAAGCGCAGCGGCAAAGCCTGCGCATGATCACCGGCAAGGTGCTGATGGACCAGAACGCGCCCGATGGCGT
GCGGGACGAGACCCGGCAAAGCCTGATCGATACCGAGGCGCTGATTGAAAAATGGCATGGCGTGGACCGGCTGGGCTACG
CCATTACGCCGCGCTTTGTGCCCAGTTGCAGCGAGGCCCAGCTGCGCGGCGCAGGCGAACTCGCCGCGCAATACCCGGAT
GTCTGGATTCAGTCGCACGTGGCAGAAAACAGGGACGAAGTCGCCTGGGTGCGCCAACTCTATCCCCAGGCCCGCAGCTA
CCTGAGCGTGTATGAGGATTTCGGCCTGCTCAGGCCGCGCGCCGTCTATGCACACTGCATTCACCTCGATGAAGACGACC
GCGCCCTGATGCGCAGCACCGGCACCGCCGCGGCAGTCAGCCCGACCAGCAACCTGTTCCTTGGCAGCGGCTTCTTTGAC
CATGCCGGCGCCGACCGCGCAGGCTTTCTGTATGGCCTGGCCAGCGATGTGGGGGGCGGCACCAGCTTTAGTCCGTTTCA
CACCATGCTGGCGGCGTATTACGTGGGGAGGGAAGGGCAGACCAAACCCGGCGTGTCGCTCAAGCCCCAGCATCTGTGGT
GGCAACACACCGCCGGTGCGGCCCGGGCACTGGGCCTGCAGGGCGTGGTGGGCAACCTGCTGTCCGGCTGCGAAGCCGAC
TTTGTGGTGCTCAATCCGCAGGCCACGCCGCTGCTGGCCCGCAAGACCAGCCAGGCCGGCAGCCTGGACGAGTTGCTGTT
TTCCCTGATCGTGCTGGGCGACGACCGTTTGATCGAGAAAACCGTGATTTCGCAGGCAGGAACAGCCTGA

Upstream 100 bases:

>100_bases
GGTACGGGTCTGGCGCGCCTCGCTGGGCGATGGCTGCCGCGTAAGCCGTTGAGCGGAAGTCCCCGGGGGCCAAGCAGATA
ATGCTCATCCGGCGCGGCAT

Downstream 100 bases:

>100_bases
TTGCCGATGTTGTAAGCATAGACCCCTTGCAGTCCGTGCAAAAATTGCGCAAGAAGCTATACAAACGATGGCAAGTTCAA
TCGGCTGGTGGCACAGGCAG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MHCRPRCGNLAGMKAYRASLLYFAAPESLPGQVTFEQDGLLVVGPDATGRQVVQAIGSYQQLASQVGSQYPGLQVEHLPG
RIIAPGFVDMHIHYPQIDVIGSPAEGLLPWLENYTFPHEKRFSSPEYSAEAATFFIAELLRHGVTTALAFATSHPESVNA
LLGEAQRQSLRMITGKVLMDQNAPDGVRDETRQSLIDTEALIEKWHGVDRLGYAITPRFVPSCSEAQLRGAGELAAQYPD
VWIQSHVAENRDEVAWVRQLYPQARSYLSVYEDFGLLRPRAVYAHCIHLDEDDRALMRSTGTAAAVSPTSNLFLGSGFFD
HAGADRAGFLYGLASDVGGGTSFSPFHTMLAAYYVGREGQTKPGVSLKPQHLWWQHTAGAARALGLQGVVGNLLSGCEAD
FVVLNPQATPLLARKTSQAGSLDELLFSLIVLGDDRLIEKTVISQAGTA

Sequences:

>Translated_449_residues
MHCRPRCGNLAGMKAYRASLLYFAAPESLPGQVTFEQDGLLVVGPDATGRQVVQAIGSYQQLASQVGSQYPGLQVEHLPG
RIIAPGFVDMHIHYPQIDVIGSPAEGLLPWLENYTFPHEKRFSSPEYSAEAATFFIAELLRHGVTTALAFATSHPESVNA
LLGEAQRQSLRMITGKVLMDQNAPDGVRDETRQSLIDTEALIEKWHGVDRLGYAITPRFVPSCSEAQLRGAGELAAQYPD
VWIQSHVAENRDEVAWVRQLYPQARSYLSVYEDFGLLRPRAVYAHCIHLDEDDRALMRSTGTAAAVSPTSNLFLGSGFFD
HAGADRAGFLYGLASDVGGGTSFSPFHTMLAAYYVGREGQTKPGVSLKPQHLWWQHTAGAARALGLQGVVGNLLSGCEAD
FVVLNPQATPLLARKTSQAGSLDELLFSLIVLGDDRLIEKTVISQAGTA
>Mature_449_residues
MHCRPRCGNLAGMKAYRASLLYFAAPESLPGQVTFEQDGLLVVGPDATGRQVVQAIGSYQQLASQVGSQYPGLQVEHLPG
RIIAPGFVDMHIHYPQIDVIGSPAEGLLPWLENYTFPHEKRFSSPEYSAEAATFFIAELLRHGVTTALAFATSHPESVNA
LLGEAQRQSLRMITGKVLMDQNAPDGVRDETRQSLIDTEALIEKWHGVDRLGYAITPRFVPSCSEAQLRGAGELAAQYPD
VWIQSHVAENRDEVAWVRQLYPQARSYLSVYEDFGLLRPRAVYAHCIHLDEDDRALMRSTGTAAAVSPTSNLFLGSGFFD
HAGADRAGFLYGLASDVGGGTSFSPFHTMLAAYYVGREGQTKPGVSLKPQHLWWQHTAGAARALGLQGVVGNLLSGCEAD
FVVLNPQATPLLARKTSQAGSLDELLFSLIVLGDDRLIEKTVISQAGTA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=371, Percent_Identity=34.7708894878706, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1789249, Length=436, Percent_Identity=41.5137614678899, Blast_Score=351, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=32.2388059701493, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24643849, Length=409, Percent_Identity=34.2298288508557, Blast_Score=198, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48763; Mature: 48763

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCRPRCGNLAGMKAYRASLLYFAAPESLPGQVTFEQDGLLVVGPDATGRQVVQAIGSYQ
CCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHH
QLASQVGSQYPGLQVEHLPGRIIAPGFVDMHIHYPQIDVIGSPAEGLLPWLENYTFPHEK
HHHHHHCCCCCCCEEECCCCCEECCCEEEEEEECCEEEEECCCHHHHHHHHHCCCCCHHH
RFSSPEYSAEAATFFIAELLRHGVTTALAFATSHPESVNALLGEAQRQSLRMITGKVLMD
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
QNAPDGVRDETRQSLIDTEALIEKWHGVDRLGYAITPRFVPSCSEAQLRGAGELAAQYPD
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCEECCCCCCCCCHHHHCCCHHHHHHCCH
VWIQSHVAENRDEVAWVRQLYPQARSYLSVYEDFGLLRPRAVYAHCIHLDEDDRALMRST
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHCC
GTAAAVSPTSNLFLGSGFFDHAGADRAGFLYGLASDVGGGTSFSPFHTMLAAYYVGREGQ
CCCEEECCCCCEEEECCCCCCCCCCCCHHHEEHHHHCCCCCCCHHHHHHHHHHHHCCCCC
TKPGVSLKPQHLWWQHTAGAARALGLQGVVGNLLSGCEADFVVLNPQATPLLARKTSQAG
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCCCCCC
SLDELLFSLIVLGDDRLIEKTVISQAGTA
CHHHHHHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MHCRPRCGNLAGMKAYRASLLYFAAPESLPGQVTFEQDGLLVVGPDATGRQVVQAIGSYQ
CCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHH
QLASQVGSQYPGLQVEHLPGRIIAPGFVDMHIHYPQIDVIGSPAEGLLPWLENYTFPHEK
HHHHHHCCCCCCCEEECCCCCEECCCEEEEEEECCEEEEECCCHHHHHHHHHCCCCCHHH
RFSSPEYSAEAATFFIAELLRHGVTTALAFATSHPESVNALLGEAQRQSLRMITGKVLMD
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
QNAPDGVRDETRQSLIDTEALIEKWHGVDRLGYAITPRFVPSCSEAQLRGAGELAAQYPD
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCEECCCCCCCCCHHHHCCCHHHHHHCCH
VWIQSHVAENRDEVAWVRQLYPQARSYLSVYEDFGLLRPRAVYAHCIHLDEDDRALMRST
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHCC
GTAAAVSPTSNLFLGSGFFDHAGADRAGFLYGLASDVGGGTSFSPFHTMLAAYYVGREGQ
CCCEEECCCCCEEEECCCCCCCCCCCCHHHEEHHHHCCCCCCCHHHHHHHHHHHHCCCCC
TKPGVSLKPQHLWWQHTAGAARALGLQGVVGNLLSGCEADFVVLNPQATPLLARKTSQAG
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCCCCCC
SLDELLFSLIVLGDDRLIEKTVISQAGTA
CHHHHHHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]