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The map label for this gene is ghrA [H]

Identifier: 91786332

GI number: 91786332

Start: 435607

End: 436572

Strand: Reverse

Name: ghrA [H]

Synonym: Bpro_0422

Alternate gene names: 91786332

Gene position: 436572-435607 (Counterclockwise)

Preceding gene: 91786333

Following gene: 91786331

Centisome position: 8.4

GC content: 68.63

Gene sequence:

>966_bases
ATGGAATTGAACGCCATCAGGAAGCCGGCGCCTTGCGTGGCGCTGCTCAGCGAGGAGCTGAACATGCAGTACCTCGCCGA
CGCCTTCAACGAGGTCTGCCCCGGCGTCGACCTGCGCATGGGTTCCGACCTCGGCATTCTTGAAGACATTGACGCGGCCG
TCTGCTGGTTTCCGCCGCACGGCCTGCTCGCGCAGCTCCCCAATCTGACGCTGGTGCAGTCGCTCGCCGCAGGCATCGAC
CACATCGTGGCCGACCCGGAGCTGCCGCGCCAACTACCGCTGTGCCGCATCGTCGACACCGGCATGGCCGCAGGCATGAA
GGCCTATGTGAGCTGGGCGGTGGTACAGCACCACCGCGGCATGAAGGCCTATGTGGCCAGCTCCGCTGCCGGTCAATGGC
AGGAGCAGGACGTCGTTTCGCCGCGCCGCCATCGTGTCGGCATCGCGGGCCTGGGCACGCTGGGCATGGCCTGCGCCGAG
GCGCTCGCGACCATCGGCTACACCGTGCGCGGCTGGAGCCGCAGCGCCAAGGACGCGCTACCCGACGGGGTGACCGGCTT
CCACGGCGACGGCCAGCTCGACGCGTTTCTCTCGGGCTGCGACACGCTGGTGTGCCTGCTGCCGCTGACGCCGCAGACGC
GGGGCTTCCTCAACGCCGGACTGTTCGCCAAACTGCCGCGCGGCGCGCACCTGATCAACGTCGGCCGCGGCGCCCACCTG
GTCGAAGCCGATCTGCTGCCTGCGCTGGAAAGCGGCCAGCTATCGGCCGCCACGCTCGACGCTTTCTCGCAGGAGCCGCT
GCCGCGGGACCATCCGTTCTGGGGCAACGCGCGCATCCTCATCACGCCACACATCGCGACCCGCACCGACCGCCTGGTCA
TTGCGCAGCAGACGCTCGCCAACCTTGCATCGTTGCAACAGGGTCAGCGCCCGGTCAACCTGGTTGACCTGGCGCGCGGC
TACTGA

Upstream 100 bases:

>100_bases
TGGGCAATCCGCAGCATGCGTACACGCGGCAACTGATCGATGCGGTGCCGCGGCTGGCGTCGCCGAATGCATTGGACGAA
ACCCCTGCGATGGTGGCTTG

Downstream 100 bases:

>100_bases
GCGGCGGCGCACCAGCCTGACTTCACTGACTTTATCTTGCAACCGGCCCCATCCATGAACGCATTTACCCATGCAGAGAA
CGCTGCGCACGACATTGCGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MELNAIRKPAPCVALLSEELNMQYLADAFNEVCPGVDLRMGSDLGILEDIDAAVCWFPPHGLLAQLPNLTLVQSLAAGID
HIVADPELPRQLPLCRIVDTGMAAGMKAYVSWAVVQHHRGMKAYVASSAAGQWQEQDVVSPRRHRVGIAGLGTLGMACAE
ALATIGYTVRGWSRSAKDALPDGVTGFHGDGQLDAFLSGCDTLVCLLPLTPQTRGFLNAGLFAKLPRGAHLINVGRGAHL
VEADLLPALESGQLSAATLDAFSQEPLPRDHPFWGNARILITPHIATRTDRLVIAQQTLANLASLQQGQRPVNLVDLARG
Y

Sequences:

>Translated_321_residues
MELNAIRKPAPCVALLSEELNMQYLADAFNEVCPGVDLRMGSDLGILEDIDAAVCWFPPHGLLAQLPNLTLVQSLAAGID
HIVADPELPRQLPLCRIVDTGMAAGMKAYVSWAVVQHHRGMKAYVASSAAGQWQEQDVVSPRRHRVGIAGLGTLGMACAE
ALATIGYTVRGWSRSAKDALPDGVTGFHGDGQLDAFLSGCDTLVCLLPLTPQTRGFLNAGLFAKLPRGAHLINVGRGAHL
VEADLLPALESGQLSAATLDAFSQEPLPRDHPFWGNARILITPHIATRTDRLVIAQQTLANLASLQQGQRPVNLVDLARG
Y
>Mature_321_residues
MELNAIRKPAPCVALLSEELNMQYLADAFNEVCPGVDLRMGSDLGILEDIDAAVCWFPPHGLLAQLPNLTLVQSLAAGID
HIVADPELPRQLPLCRIVDTGMAAGMKAYVSWAVVQHHRGMKAYVASSAAGQWQEQDVVSPRRHRVGIAGLGTLGMACAE
ALATIGYTVRGWSRSAKDALPDGVTGFHGDGQLDAFLSGCDTLVCLLPLTPQTRGFLNAGLFAKLPRGAHLINVGRGAHL
VEADLLPALESGQLSAATLDAFSQEPLPRDHPFWGNARILITPHIATRTDRLVIAQQTLANLASLQQGQRPVNLVDLARG
Y

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=243, Percent_Identity=28.8065843621399, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI23308577, Length=177, Percent_Identity=29.9435028248588, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081824, Length=311, Percent_Identity=38.9067524115756, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082289, Length=287, Percent_Identity=31.0104529616725, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=243, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=28.2352941176471, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574286, Length=276, Percent_Identity=27.8985507246377, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585516, Length=244, Percent_Identity=27.4590163934426, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571528, Length=176, Percent_Identity=31.25, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34336; Mature: 34336

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNAIRKPAPCVALLSEELNMQYLADAFNEVCPGVDLRMGSDLGILEDIDAAVCWFPPH
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCHHHCCCEEEEECCC
GLLAQLPNLTLVQSLAAGIDHIVADPELPRQLPLCRIVDTGMAAGMKAYVSWAVVQHHRG
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MKAYVASSAAGQWQEQDVVSPRRHRVGIAGLGTLGMACAEALATIGYTVRGWSRSAKDAL
CHHHHHCCCCCCCCHHHCCCCHHHEECEECHHHHHHHHHHHHHHHCCEEECCCCCHHHCC
PDGVTGFHGDGQLDAFLSGCDTLVCLLPLTPQTRGFLNAGLFAKLPRGAHLINVGRGAHL
CCCCCCCCCCCCHHHHHHHHCEEEEEECCCCCCCCHHCCCHHHCCCCCCEEEEECCCCEE
VEADLLPALESGQLSAATLDAFSQEPLPRDHPFWGNARILITPHIATRTDRLVIAQQTLA
EHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHH
NLASLQQGQRPVNLVDLARGY
HHHHHHHCCCCCCHHHHCCCC
>Mature Secondary Structure
MELNAIRKPAPCVALLSEELNMQYLADAFNEVCPGVDLRMGSDLGILEDIDAAVCWFPPH
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCHHHCCCEEEEECCC
GLLAQLPNLTLVQSLAAGIDHIVADPELPRQLPLCRIVDTGMAAGMKAYVSWAVVQHHRG
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MKAYVASSAAGQWQEQDVVSPRRHRVGIAGLGTLGMACAEALATIGYTVRGWSRSAKDAL
CHHHHHCCCCCCCCHHHCCCCHHHEECEECHHHHHHHHHHHHHHHCCEEECCCCCHHHCC
PDGVTGFHGDGQLDAFLSGCDTLVCLLPLTPQTRGFLNAGLFAKLPRGAHLINVGRGAHL
CCCCCCCCCCCCHHHHHHHHCEEEEEECCCCCCCCHHCCCHHHCCCCCCEEEEECCCCEE
VEADLLPALESGQLSAATLDAFSQEPLPRDHPFWGNARILITPHIATRTDRLVIAQQTLA
EHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHH
NLASLQQGQRPVNLVDLARGY
HHHHHHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA