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The map label for this gene is pcaR [H]

Identifier: 91786288

GI number: 91786288

Start: 390220

End: 391011

Strand: Direct

Name: pcaR [H]

Synonym: Bpro_0378

Alternate gene names: 91786288

Gene position: 390220-391011 (Clockwise)

Preceding gene: 91786287

Following gene: 91786290

Centisome position: 7.5

GC content: 61.36

Gene sequence:

>792_bases
ATGACATCCACAATCCGTCAACCGCCTGCCGTCAGTTCGCTGTTCAACCAGTCCCTTGAAAAAGGGCTGGCGGTTCTGCG
CGCCTTTGATGCTGCACACCGGACGTTGACGTTGGCCGAGCTGGCTACGCTGACCGGCATGAGCAAAGGGTCGGCACAGC
GCACCGTGCACACGCTGCAGCAACTGGGTTATGTGGGCAAGCACCCGCAAACACGGCGCTTTCAGCTGCTTCCCAGGGTG
ATAGAAATCGGCTTTAACTACCTAGCTGCGCATCCTTTGATACGCGTGGCCAATCCTTATCTTTCGCAGCTCGCCAATGC
CAGCGGCGAGACGGCCAGCCTCACCGAGCCGGTAGGGCTGGACATGGTCTACGTGGCCCAGTTGGTCACCTCCAAGTTCA
TTCCGGTGCATACGCCAGTGGGCATGCGAATTCCCATGTACTGCACCAGCTCTGGCAGGGCCTGGCTCAGCGCGCTGCCC
GACGCTCAGGTACGGGCCGTCCTGGAGGCATCGACACGCGTGGCGCGCACACCGTACACGCTGACGGATGTCGACGCCAT
CCTTGCGCGTGTTGCGGCCTGCCGGCAGGTCGGTTATGCCAGCAACTGCGAGGAGTTGTTTCTGGGTGACATGGGCATCG
GTGCACCGATTCTTGACAGCAACGGACAGGCCGTCGCGGCTGTCCACCTTTCCCCGCCGACGAGCCGCTGGACGATGGAA
GAGGCACAGAGAAAGTTGTCGCCCATGGTGATCGAGTGCGCACGGGCTATCTCGCAGTCCATCGCGCATTAA

Upstream 100 bases:

>100_bases
CTCTGCAAAGCCATCAACTCGCCGGTTCTACACGGAATTTTTGTTATGAGCCCTTGTGATGCAAGCGTTTTAAAAGCGAC
CTGTACCACTTCCCGCCATC

Downstream 100 bases:

>100_bases
ACAGCGGACGCCGCGCTCTCCAGTCAACGCTCTCGATTTCCCTTCACTGCGCCCGCTCCAGCATGGCCAGCAGCAACACG
TTGGCCCCGGCGGCAATGTG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTSTIRQPPAVSSLFNQSLEKGLAVLRAFDAAHRTLTLAELATLTGMSKGSAQRTVHTLQQLGYVGKHPQTRRFQLLPRV
IEIGFNYLAAHPLIRVANPYLSQLANASGETASLTEPVGLDMVYVAQLVTSKFIPVHTPVGMRIPMYCTSSGRAWLSALP
DAQVRAVLEASTRVARTPYTLTDVDAILARVAACRQVGYASNCEELFLGDMGIGAPILDSNGQAVAAVHLSPPTSRWTME
EAQRKLSPMVIECARAISQSIAH

Sequences:

>Translated_263_residues
MTSTIRQPPAVSSLFNQSLEKGLAVLRAFDAAHRTLTLAELATLTGMSKGSAQRTVHTLQQLGYVGKHPQTRRFQLLPRV
IEIGFNYLAAHPLIRVANPYLSQLANASGETASLTEPVGLDMVYVAQLVTSKFIPVHTPVGMRIPMYCTSSGRAWLSALP
DAQVRAVLEASTRVARTPYTLTDVDAILARVAACRQVGYASNCEELFLGDMGIGAPILDSNGQAVAAVHLSPPTSRWTME
EAQRKLSPMVIECARAISQSIAH
>Mature_262_residues
TSTIRQPPAVSSLFNQSLEKGLAVLRAFDAAHRTLTLAELATLTGMSKGSAQRTVHTLQQLGYVGKHPQTRRFQLLPRVI
EIGFNYLAAHPLIRVANPYLSQLANASGETASLTEPVGLDMVYVAQLVTSKFIPVHTPVGMRIPMYCTSSGRAWLSALPD
AQVRAVLEASTRVARTPYTLTDVDAILARVAACRQVGYASNCEELFLGDMGIGAPILDSNGQAVAAVHLSPPTSRWTMEE
AQRKLSPMVIECARAISQSIAH

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=258, Percent_Identity=27.5193798449612, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786468, Length=220, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786715, Length=246, Percent_Identity=26.0162601626016, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082359, Length=244, Percent_Identity=26.6393442622951, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789999, Length=250, Percent_Identity=27.6, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI145693096, Length=237, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788581, Length=215, Percent_Identity=24.6511627906977, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28393; Mature: 28262

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTIRQPPAVSSLFNQSLEKGLAVLRAFDAAHRTLTLAELATLTGMSKGSAQRTVHTLQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QLGYVGKHPQTRRFQLLPRVIEIGFNYLAAHPLIRVANPYLSQLANASGETASLTEPVGL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC
DMVYVAQLVTSKFIPVHTPVGMRIPMYCTSSGRAWLSALPDAQVRAVLEASTRVARTPYT
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCC
LTDVDAILARVAACRQVGYASNCEELFLGDMGIGAPILDSNGQAVAAVHLSPPTSRWTME
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEECCCCCEEEEEEECCCCCCCCHH
EAQRKLSPMVIECARAISQSIAH
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSTIRQPPAVSSLFNQSLEKGLAVLRAFDAAHRTLTLAELATLTGMSKGSAQRTVHTLQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QLGYVGKHPQTRRFQLLPRVIEIGFNYLAAHPLIRVANPYLSQLANASGETASLTEPVGL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC
DMVYVAQLVTSKFIPVHTPVGMRIPMYCTSSGRAWLSALPDAQVRAVLEASTRVARTPYT
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCC
LTDVDAILARVAACRQVGYASNCEELFLGDMGIGAPILDSNGQAVAAVHLSPPTSRWTME
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEECCCCCEEEEEEECCCCCCCCHH
EAQRKLSPMVIECARAISQSIAH
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]