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The map label for this gene is Hgd [H]

Identifier: 91786106

GI number: 91786106

Start: 213137

End: 214030

Strand: Reverse

Name: Hgd [H]

Synonym: Bpro_0195

Alternate gene names: 91786106

Gene position: 214030-213137 (Counterclockwise)

Preceding gene: 91786107

Following gene: 91786103

Centisome position: 4.12

GC content: 67.0

Gene sequence:

>894_bases
ATGAAACACATTGGAATGATCGGCGCCTCGGGCCTGATGGGCCACGGCATTGCACGCAACCTGCAGGCCAAGGGCTTTGA
CCTCAGCCTGACCGTGCACCGCAACACCGAGCGCGTGGCCGACCTGCTGGCCGCCGGCGCCAAACAGGTCGCCAGCCCCG
CCGGGCTGGGCGACTGCGACGCGGTGATCATCTGCGTCACCGGTTCGCCCCAGGTGGAGCAAACCCTGTCCGGGCCCGAC
GGCGTGCTGTCCAGGGCGCTCGCCGGGCTGATCGTGATCGATACGTCCACCAGCGAGCCGGAGTCGACGCGGCGCCTGGC
CGCCCTGTGTGCCGAGCGCGGCGTTACGCTGGTGGATGCGCCGCTGGCGCGCACGCCGGTGGAAGCCGAGTTGGGCAGGC
TCAACACCATGGTCGGCGCCGAGCAGGCGGTGTTCGACAAAATTCGTCCGGTGCTGGCGGCCTATTGCGAAAACATCTTT
CATGTCGGCGGCCCCGGCGCCGGCCACGTGATCAAGCTGCTCAACAACTTCATCGGCCAGGCCATTTGCACCGCCACGGC
CGAAGCCTTTGCGGTGGGCGCACTGGCCGGAATCAATCCGCAAAAGCTGGTCGAGGTGATCTCGGCCGGCGCGGTGAACT
CCGGCCTGTTCCAGGCGATGGCCAAGACCTTGAACGGCGATTTCACAGGCCTGAAGTTCGAGCTGGACAACGCGCGCAAG
GACTTGCGCTACTACACCCACCTGGCCGAAATGGTGAACGTGCCCTCGCTCGTCGGCGAAGCCGTGCACCAGAGCCTGGC
CACCGCCAGCGCGCTGGGCCAGGGGAAAAAGTTCGTCCCGGCCCTGGTGACGGCGCAGGAGAAGCTCACCGGCGCGAAGA
TCGCGCCGCAGTGA

Upstream 100 bases:

>100_bases
CGCTAGGCCTGCACGCGCACGCACCCAAAACCACCTTGCTGATGGGCCGGAGTACAGTGCGAACTCAAAACCTTCCCGCT
AATTTTCACAGGAGACAAGC

Downstream 100 bases:

>100_bases
ACTGAAGCCTTGGCGCGCTACAGCGCTTTTCCGTAGACCAGGAAGCCCGAGCGTTCTCCGACCTTGTCATACAGCTTCAT
CGCCGTGGTGTTCGTCTCGT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGLGDCDAVIICVTGSPQVEQTLSGPD
GVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVDAPLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIF
HVGGPGAGHVIKLLNNFIGQAICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMAKTLNGDFTGLKFELDNARK
DLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEKLTGAKIAPQ

Sequences:

>Translated_297_residues
MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGLGDCDAVIICVTGSPQVEQTLSGPD
GVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVDAPLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIF
HVGGPGAGHVIKLLNNFIGQAICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMAKTLNGDFTGLKFELDNARK
DLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEKLTGAKIAPQ
>Mature_297_residues
MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGLGDCDAVIICVTGSPQVEQTLSGPD
GVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVDAPLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIF
HVGGPGAGHVIKLLNNFIGQAICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMAKTLNGDFTGLKFELDNARK
DLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEKLTGAKIAPQ

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=26.2237762237762, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI23308751, Length=283, Percent_Identity=27.208480565371, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=29.7945205479452, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790315, Length=286, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786719, Length=300, Percent_Identity=30.6666666666667, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=28.2828282828283, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30741; Mature: 30741

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGLGDCD
CCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCC
AVIICVTGSPQVEQTLSGPDGVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVDA
EEEEEECCCCCHHHHCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
PLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIFHVGGPGAGHVIKLLNNFIGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMAKTLNGDFTGLKFELDNARK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECHHHH
DLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEKLTGAKIAPQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGLGDCD
CCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCC
AVIICVTGSPQVEQTLSGPDGVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVDA
EEEEEECCCCCHHHHCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
PLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIFHVGGPGAGHVIKLLNNFIGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMAKTLNGDFTGLKFELDNARK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECHHHH
DLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEKLTGAKIAPQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA