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The map label for this gene is patB [H]

Identifier: 91213925

GI number: 91213925

Start: 4881012

End: 4882190

Strand: Direct

Name: patB [H]

Synonym: UTI89_C4977

Alternate gene names: 91213925

Gene position: 4881012-4882190 (Clockwise)

Preceding gene: 91213919

Following gene: 91213926

Centisome position: 96.35

GC content: 40.46

Gene sequence:

>1179_bases
ATGAAAGTTTATAATTTTGATAAAGTTATTTCACGCGACGGAACCTATAGCGCTAAATATAATAACAAGGGGCATGACAT
CATTCCTCTGTCTGTAGCTGATATGGATATTCCTGTAGCTGATTTTATAGTTTCTGAATTATCTGTCGCAAATCAGAAAG
GTATCTACGGTTATACATTATTAAGTGATGACTGGCAGCAAGTGGCAGCACAGTGGTATCAACGCCATTACTCGTGGAAG
GTCAACCCTGAACACATTGTTTTTTGCCCACGGGTAGTACAGGCCGTCTCATTATTTATCCAGAACTTTACCCAACCGGG
AGATGCTATTGTCAGCCTGACACCAGCCTATCATCCTATTAGTCATGCAGTTGAAGTCAACCATCGAGTATTGCTGGAAA
GTGCGTTACTTTATCGTGACCACCACTATGAAATAGACTTTGCGGATCTCGAAGATAAGTTTAAAATGGCTTGTTGTTTC
ATTCTAATATCGCCGCATAATCCAACAGGAACAATCTGGTCAGAAGACAATCTAAGGAAAATAGCTTCATTAGCAGAAAA
ATATAATATTTTTATTATTTCTGATGATGTTCATGCAGACTTCAACTTCACCCAAAAACAACATCAAACAATTTCTTCTA
TAAGCTCATACGTTGCACAAAACTCGTTTATTTGTACATCTCCAGCAAAAACTTTTAATATGGCCGGACTTGAAATCGCA
AATATTGTTATTGCTAACGATAAATATCGTGAACAGTTTAAATTAGCTCTTATTGCAGCAGGTATCCATAATCCTGGTTA
TTTCTCTGTTCCTGCATTTCTCTGTGCTTACCGCCATGGCGATTCTTGGTTAGCAGCATTAAAAGATTATTTGGTCGAAA
ACAGGAGCTGGGTTCAATCATTCTGCCAAGCTCATTTTCCAGACTGGTTTGTCGCCTCTGGTGGCGGAACTTACATGTTG
TGGATCGACTACCGGGCAATGAACATCAGCGAAGAGCAACTACGCCATTGGTTTGTCTCGCTCGCAGGTGTTGAGATGAG
CTGGGGATCAGATTTTGGCGATGAAGGACTTGGTTTTTTCCGTGTGAACATAGCCACGCCGAGAAGCAATCTTACACAAG
CATTTGAACGGATTTATCAGAGCATCCCCTTCACTACAGGAGTTTCCCTTCATGAATAA

Upstream 100 bases:

>100_bases
ATATGCAAATTTTCATAATAACGAAAACAAAATACAGAATAACACTTCCTCCCTCGATATATTACGTTACCCTAACGATA
AAATCGGGCGAGTAACAAAT

Downstream 100 bases:

>100_bases
TAACAATACTCCAAGATCCCCAACTCTGGTGGAATCATTATTACCAATACTAGCGATGATACTATTGCTGGGATTTGGTT
ATGCGGCATTCGATCTGCCA

Product: hypothetical protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK
VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF
ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA
NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML
WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE

Sequences:

>Translated_392_residues
MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK
VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF
ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA
NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML
WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE
>Mature_392_residues
MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK
VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF
ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA
NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML
WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=28.7917737789203, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786816, Length=325, Percent_Identity=21.8461538461538, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787710, Length=295, Percent_Identity=23.0508474576271, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44634; Mature: 44634

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTL
CCEECCHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE
LSDDWQQVAAQWYQRHYSWKVNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPI
ECCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCFILISPHNPTGTIWSEDNLRK
HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHEEEEEEEEEECCCCCCCEECCCHHHH
IASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA
HHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCEEEE
NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQS
EEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
FCQAHFPDWFVASGGGTYMLWIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFF
HHHHCCCCEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCCCEEE
RVNIATPRSNLTQAFERIYQSIPFTTGVSLHE
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTL
CCEECCHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE
LSDDWQQVAAQWYQRHYSWKVNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPI
ECCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCFILISPHNPTGTIWSEDNLRK
HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHEEEEEEEEEECCCCCCCEECCCHHHH
IASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA
HHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCEEEE
NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQS
EEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
FCQAHFPDWFVASGGGTYMLWIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFF
HHHHCCCCEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCCCEEE
RVNIATPRSNLTQAFERIYQSIPFTTGVSLHE
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]