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The map label for this gene is mtlD [H]

Identifier: 91213111

GI number: 91213111

Start: 4030034

End: 4031362

Strand: Direct

Name: mtlD [H]

Synonym: UTI89_C4138

Alternate gene names: 91213111

Gene position: 4030034-4031362 (Clockwise)

Preceding gene: 91213110

Following gene: 91213112

Centisome position: 79.55

GC content: 52.97

Gene sequence:

>1329_bases
ATGCCTGATGCGACGCTGACGCGTCTTATCAGGCCTACAGGTCAGTGCCAAACACGTAGGCCGGATAAGGCGTTTACGCC
GCATCCGGCAAAAAGCCCCTCTCCTCACGGAGAGGGTTTGGGTGAGGGAAAAGCCTCACCCCAGCCCTCTCGGGTAAAAA
CATTGATGAAGGTTAATACTATGAAAGCATTACATTTTGGCGCAGGTAATATCGGTCGTGGCTTTATCGGTAAACTGCTG
GCGGACGCGGGTATCCAACTGACGTTTGCCGATGTAAATCAGGTGGTACTTGATGCCCTGAATGCCCGTCATAGCTATCA
GGTTCATGTGGTCGGCGAAACCGAGCAGGTGGATACCGTTTCTGGCGTCGATGCCGTCAGCAGCATTGGCGATGATGTCG
TTGATCTGATTGCTCAGGTCGATTTAGTCACTACCGCCGTTGGCCCTGTCGTGCTGGAACGTATTGCTCCGGCCATCGCC
AAAGGGCTGGTGAAACGTAAAGAACAAGGTAATGAATCCCCACTGAACATCATCGCCTGTGAAAACATGGTCCGCGGCAC
CACGCAGCTGAAAGGCCATGTGATGAACGCCCTGCCGGAAGATGCCAAAGCGTGGGTAGAAGAACACGTTGGCTTTGTTG
ATTCCGCCGTTGACCGCATCGTACCGCCTTCGGCTTCGGCAACTAACGATCCGCTGGAAGTGACGGTAGAAACCTTCAGC
GAATGGATTGTCGATAAAACGCAGTTCAAAGGCACGCTGCCAAACATCCCTGGCATGGAATTAACCGACAATCTGATGGC
ATTTGTCGAACGTAAACTCTTCACCCTGAATACAGGTCATGCTATAACCGCGTACCTCGGAAAACTGGCCGGTCATCAGA
CCATTCGTGACGCAATTCTCGACGAGAAAATCCGCGCGGTGGTAAAAGGGGCAATGGAAGAAAGCGGCGCGGTACTGATC
AAGCGCTACGACTTTGATGCTGACAAACATGCGGCATACATCCAGAAAATCCTCGGTCGTTTCGAGAACCCGTACCTGAA
AGATGATGTAGAACGCGTAGGCCGTCAGCCGCTGCGTAAACTGAGTGCTGGCGACCGTCTGATCAAGCCACTGCTCGGAA
CCCTGGAATATGGTCTGCCACATAAAAACCTGATTGAAGGTATTGCCGCTGCAATGCACTTCCGCAGTGAAGATGACCCG
CAGGCTCAGGAACTGGCAGCGCTGATTGCCGACAAAGGCCCACAAGCCGCGCTGGCACAGATTTCCGGTCTTGATGCCAA
CAGCGAGGTTGTATCCGAGGCGGTAACCGCTTATAAAGCAATGCAATAA

Upstream 100 bases:

>100_bases
ATTGCCTGATGCGCTTCGCTTATCAGGCCTACAACATAAAGCACAATTTGTTTTGTCGGTCGGATAAGGTGTTTACGCCG
CATCCGGCAGTCGGTACACA

Downstream 100 bases:

>100_bases
TGGTGGACCAGGCGCAGGATACCCTGCGCCCGAATAACAGATTGTCAGATATGCAGGCAACAATGGAACAAACCCAGGCC
TTTGAAAACCGTGTGCTTGA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPDATLTRLIRPTGQCQTRRPDKAFTPHPAKSPSPHGEGLGEGKASPQPSRVKTLMKVNTMKALHFGAGNIGRGFIGKLL
ADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIA
KGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
EWIVDKTQFKGTLPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLI
KRYDFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDP
QAQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ

Sequences:

>Translated_442_residues
MPDATLTRLIRPTGQCQTRRPDKAFTPHPAKSPSPHGEGLGEGKASPQPSRVKTLMKVNTMKALHFGAGNIGRGFIGKLL
ADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIA
KGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
EWIVDKTQFKGTLPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLI
KRYDFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDP
QAQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ
>Mature_441_residues
PDATLTRLIRPTGQCQTRRPDKAFTPHPAKSPSPHGEGLGEGKASPQPSRVKTLMKVNTMKALHFGAGNIGRGFIGKLLA
DAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAK
GLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFSE
WIVDKTQFKGTLPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLIK
RYDFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQ
AQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=98.9528795811518, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI1788497, Length=231, Percent_Identity=29.004329004329, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787823, Length=267, Percent_Identity=28.0898876404494, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790779, Length=259, Percent_Identity=27.7992277992278, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324401, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 47673; Mature: 47542

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDATLTRLIRPTGQCQTRRPDKAFTPHPAKSPSPHGEGLGEGKASPQPSRVKTLMKVNT
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTV
HHHHHCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
SGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
EWIVDKTQFKGTLPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DEKIRAVVKGAMEESGAVLIKRYDFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
ISGLDANSEVVSEAVTAYKAMQ
HHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA