Click here to switch to the map view.

The map label for this gene is lyxK [H]

Identifier: 91213097

GI number: 91213097

Start: 4013779

End: 4015275

Strand: Direct

Name: lyxK [H]

Synonym: UTI89_C4124

Alternate gene names: 91213097

Gene position: 4013779-4015275 (Clockwise)

Preceding gene: 91213096

Following gene: 91213098

Centisome position: 79.23

GC content: 56.78

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGGCTGTATGACCGAGAAGGCCGGGAGGC
GGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGTCCACAGCCAGGCTGGGCAGAGCGCGACATGGCAGAACTGTGGCAAT
GTTGCACTGCTGTCATTCGCGCCCTGCTTACCCATTCTGGCGTCAGCGGGGAACAAATTGTCGGTATCGGCATCTCCGCG
CAGGGAAAGGGCTTATTTCTACTTGATAAAAACGACAAACCGCTCGGTAACGCCATTTTGTCCTCGGATCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGAAAGATGGCATCCCGGAAAAACTCTATCCGCTGACCCGACAAACCTTATGGACCGGGC
ATCCGGTGTCGCTGTTACGCTGGCTGAAAGAGCACAAACCAGAACGCTACGCGCAAATTGGCTGCGTGATGATGACGCAC
GACTACCTGCGCTGGTGTTTAACCGGCGTCAAAGGTTGCGAAGAGAGCAATATTTCTGAGTCCAATCTCTACAACATGGG
TCGCGGGGAATATGACCCGTACCTTACCGACTGGCTGGGGATCGCTGAAATCAATCACGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATCTGCGGGGAAATCACCGCTCAGACAGCCGTACTGACCGGTCTGAAAGCGGGTACCCCCGTTGTCGGCGGC
CTGTTTGATGTGGTTTCCACCGCACTCTGCGCCGGACTCGAAGACGAATTCACCCTCAATGCGGTGATGGGGACCTGGGC
GGTGACCAGCGGCATAACCCACGGTTTACGTGACGGTGAAGCGCATCCGTATGTCTATGGTCGCTACGTTAACGATGGTC
AATTTATCGTTCACGAAGCCAGCCCCACCTCTTCCGGCAATCTCGAATGGTTTACCGCACAGTGGGGAGAAATCTCATTT
GCTGAGATTAATCAGGCCGTTGCCAGTTTGCCGAAAGCCGGTGGCGATCTCTTCTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTCGAAATGACCAGTGGTTTCTACGGGATGCAGGCCATTCACACCCGTGCACACCTCTTACAGGCCATCTATG
AAGGGGTGGTGTTCAGCCATATGACCCATCTCAACCGGATGCGCGAACGTTTTACTGATGTGCACACCCTGCGCGTCACT
GGCGGCCCGGCGCACTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGTCTGCGTATCGAGCTGCCGCAGGTGGA
AGAAACCGGCTGCTTTGGTGCGGCACTTGCCGCCCGCGTCGGTACCGGGGTTTATCGCGATTTCAGCGAAGCCCAACGTG
ACTTGCGACACCCGGTACGCACCCTGCTGCCGGATATGGCCGCCCATCAGCTTTACCAACAAAAATACCAACGCTATCAA
CATCTCATTACCACACTTCAGGGTTATCACGCCCGCATCAAGGAGCACACATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGATGCGCTGGGTACCCAGGTCCGTGACATGTTTGTTAAAGATGTTCCGCAGGGTGCTGATCTGCTGAAAGCCG
TGGATGAGGTGCAATAAACC

Downstream 100 bases:

>100_bases
GTCGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCGCAGCGCGACGTGACGCGGTTAAAAGACAGC
GTCGATATTGTCGAAGCAGG

Product: cryptic L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQKDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHKPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMGRGEYDPYLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLRHPVRTLLPDMAAHQLYQQKYQRYQ
HLITTLQGYHARIKEHTL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQKDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHKPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMGRGEYDPYLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLRHPVRTLLPDMAAHQLYQQKYQRYQ
HLITTLQGYHARIKEHTL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISAQ
GKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQKDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHKPERYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMGRGEYDPYLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGGL
FDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISFA
EINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLRHPVRTLLPDMAAHQLYQQKYQRYQH
LITTLQGYHARIKEHTL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=513, Percent_Identity=24.9512670565302, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI164663828, Length=559, Percent_Identity=23.613595706619, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=96.3855421686747, Blast_Score=998, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=511, Percent_Identity=26.027397260274, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789987, Length=488, Percent_Identity=23.3606557377049, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790361, Length=476, Percent_Identity=23.5294117647059, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24656367, Length=519, Percent_Identity=23.3140655105973, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357867, Length=531, Percent_Identity=22.5988700564972, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655555, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655560, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655570, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655574, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655565, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656372, Length=175, Percent_Identity=27.4285714285714, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657106, Length=557, Percent_Identity=22.6211849192101, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24657102, Length=557, Percent_Identity=22.6211849192101, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55227; Mature: 55095

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQKDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHKPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMGRGEYDPYLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLRHPVRTLLPDMAAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLITTLQGYHARIKEHTL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQKDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHKPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMGRGEYDPYLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLRHPVRTLLPDMAAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLITTLQGYHARIKEHTL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]