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The map label for this gene is dapA1 [H]

Identifier: 91212949

GI number: 91212949

Start: 3865260

End: 3866144

Strand: Direct

Name: dapA1 [H]

Synonym: UTI89_C3975

Alternate gene names: 91212949

Gene position: 3865260-3866144 (Clockwise)

Preceding gene: 91212948

Following gene: 91212954

Centisome position: 76.3

GC content: 42.49

Gene sequence:

>885_bases
ATGAAAGAGCTCAAAGGGATTATTACCGCAATGGTAACGCCTTTCGATGAAACGGAAAAAATGGATATCACTGCGGCGAA
AAAAATGGCGCGCTGGTTAGTAGATAATGGTGTTCATGGTTTATTCATTTGCGGAACTAATGGTGAATTCCATTTGCTTT
CCGATGACGAAAAAGTTGAGTTAACAAAAGCCGTCGTTGAAGAGGTCGGTAATGAAGTTACCATTTGTGCAGGTGCTGGG
TGCTGCAGCACAAAACAAACCATCGAATTGACTAAACGGTTAGTTGATGCGGGTGCCGATTATATTTCTGTTGTCACGCC
GTACTATCTGGTACCAAATCAGGAAGATTTATACCGTCACTATTACGATATTGCCTTTAGCACAACAGCCCCCATCATTC
TCTATAACCTGCCGGGCCAGACAGGATTAAGCATCGAATACGAAACGGCAAATCGTTTAGCCGATATCAAAAATATCGTA
GCGATAAAAGACAGTAGCGGTAAATTCGAAGTCCAGAAACAGTATCTGGAAATCGCTAAACATAAAAACTTTAAGGTATT
AAACGGCTCTGACTCGTTAATGCTGGATGCATTTAAAGAAGGTTCTGTGGCTGCTGTCGCTGCAACGTCGAATGTTCTGC
CTACGATTGAAGTCGATTTATATAATTACTTCATGGCCGGTGAAATGGAGAAGGCGCAGGAAGAGCGTAATAAAATGGAT
GCACTGCGCATGACGATCAAGAAAATGACCGCGCCTGCAGTAATGAAGGAAGCATTAAACCTGATGGGTGTGAAGGCAGG
TATTACACGTAGACCAATTCATATGCCAAACGACGCGATCGTTGAAGACATCAAGGAAATGTTGAAAGGCTATAATTTCC
TGTAA

Upstream 100 bases:

>100_bases
ATTCTATTACCCCTCATGCCGCTTCATTTACCGATGAGGCCGACCATAACACAATGCAAATTTCTATTAAAAACGTATTA
CAGGAACTGGAGAAAGAGTA

Downstream 100 bases:

>100_bases
AGGACAAATGCCGGATGTATCTCTTGTCCTACAAGATAGCGTAAACAAAAACCCCCGGACTCAAATCCAGGGGTTATCTG
TGGCAACTTAACGCGCTGCG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 1 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKELKGIITAMVTPFDETEKMDITAAKKMARWLVDNGVHGLFICGTNGEFHLLSDDEKVELTKAVVEEVGNEVTICAGAG
CCSTKQTIELTKRLVDAGADYISVVTPYYLVPNQEDLYRHYYDIAFSTTAPIILYNLPGQTGLSIEYETANRLADIKNIV
AIKDSSGKFEVQKQYLEIAKHKNFKVLNGSDSLMLDAFKEGSVAAVAATSNVLPTIEVDLYNYFMAGEMEKAQEERNKMD
ALRMTIKKMTAPAVMKEALNLMGVKAGITRRPIHMPNDAIVEDIKEMLKGYNFL

Sequences:

>Translated_294_residues
MKELKGIITAMVTPFDETEKMDITAAKKMARWLVDNGVHGLFICGTNGEFHLLSDDEKVELTKAVVEEVGNEVTICAGAG
CCSTKQTIELTKRLVDAGADYISVVTPYYLVPNQEDLYRHYYDIAFSTTAPIILYNLPGQTGLSIEYETANRLADIKNIV
AIKDSSGKFEVQKQYLEIAKHKNFKVLNGSDSLMLDAFKEGSVAAVAATSNVLPTIEVDLYNYFMAGEMEKAQEERNKMD
ALRMTIKKMTAPAVMKEALNLMGVKAGITRRPIHMPNDAIVEDIKEMLKGYNFL
>Mature_294_residues
MKELKGIITAMVTPFDETEKMDITAAKKMARWLVDNGVHGLFICGTNGEFHLLSDDEKVELTKAVVEEVGNEVTICAGAG
CCSTKQTIELTKRLVDAGADYISVVTPYYLVPNQEDLYRHYYDIAFSTTAPIILYNLPGQTGLSIEYETANRLADIKNIV
AIKDSSGKFEVQKQYLEIAKHKNFKVLNGSDSLMLDAFKEGSVAAVAATSNVLPTIEVDLYNYFMAGEMEKAQEERNKMD
ALRMTIKKMTAPAVMKEALNLMGVKAGITRRPIHMPNDAIVEDIKEMLKGYNFL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=274, Percent_Identity=27.7372262773723, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI13540533, Length=312, Percent_Identity=24.6794871794872, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1788823, Length=290, Percent_Identity=31.0344827586207, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786463, Length=280, Percent_Identity=29.2857142857143, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082415, Length=242, Percent_Identity=31.8181818181818, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=23.4265734265734, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32669; Mature: 32669

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELKGIITAMVTPFDETEKMDITAAKKMARWLVDNGVHGLFICGTNGEFHLLSDDEKVE
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHH
LTKAVVEEVGNEVTICAGAGCCSTKQTIELTKRLVDAGADYISVVTPYYLVPNQEDLYRH
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHHCCEEECCCHHHHHHH
YYDIAFSTTAPIILYNLPGQTGLSIEYETANRLADIKNIVAIKDSSGKFEVQKQYLEIAK
HHHHEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHH
HKNFKVLNGSDSLMLDAFKEGSVAAVAATSNVLPTIEVDLYNYFMAGEMEKAQEERNKMD
CCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHH
ALRMTIKKMTAPAVMKEALNLMGVKAGITRRPIHMPNDAIVEDIKEMLKGYNFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKELKGIITAMVTPFDETEKMDITAAKKMARWLVDNGVHGLFICGTNGEFHLLSDDEKVE
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHH
LTKAVVEEVGNEVTICAGAGCCSTKQTIELTKRLVDAGADYISVVTPYYLVPNQEDLYRH
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHHCCEEECCCHHHHHHH
YYDIAFSTTAPIILYNLPGQTGLSIEYETANRLADIKNIVAIKDSSGKFEVQKQYLEIAK
HHHHEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHH
HKNFKVLNGSDSLMLDAFKEGSVAAVAATSNVLPTIEVDLYNYFMAGEMEKAQEERNKMD
CCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHH
ALRMTIKKMTAPAVMKEALNLMGVKAGITRRPIHMPNDAIVEDIKEMLKGYNFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]