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The map label for this gene is serA [H]

Identifier: 91212948

GI number: 91212948

Start: 3864340

End: 3865260

Strand: Direct

Name: serA [H]

Synonym: UTI89_C3974

Alternate gene names: 91212948

Gene position: 3864340-3865260 (Clockwise)

Preceding gene: 91212947

Following gene: 91212949

Centisome position: 76.28

GC content: 37.46

Gene sequence:

>921_bases
ATGAAAAAGATAATTATCACTCCCCGGCCTTTTGTGGGTAAAGGCAAGGTCTATATTGATAAGTTAAAATCCGCAGGTTA
TCAAGTTGAATGTAATAACAGTGGAGGTCGATATAGCAAGGAAGAACTCATCGAGAAAATTAAAGACGCGAATGCCATTA
TCACCGGAAACGATCCTCTGAGCAGAGAAGTTATTGATCAGGCAAAAAACCTGAAGGTTATTTCAAAATATGGCGTAGGG
TTAGATAACATAGATGTCGATTACGCAAATAGTAAAGACATCGTGGTACATAAAGCTCTTAATGCTAACTCTATTTCTGT
TGCAGAAATGACCATTCTGATGATGCTCTCCAGTTCCCGAAAATATGTTGAAATCGAGAGTCAGGCAAGAAATGGTAAGG
ACATCAGGCTTGTCGGGTATGAGCTATATCAAAAAAATCTGGGATTAATTGGACTTGGTGCAATTGGTCAACATGTTGCT
CATATTGCTCATTCTATGGGAATGACGATTACTGCTCATGATCCTCATATTGATAAAAGCAAGGTTCCATCCTATATAGA
ACTTAAATCACCTGATGAAATATATCAGTACAGCGATGTAATTTCTCTGCATTTACCTTTACTGGACAGTACTCGCAATA
TAATTAACGACTCTGTATTTGAGAAAATGAAATCTTCGGCTATTTTAATCAATACAGCCAGGGGTGGATTGGTCGATGAG
AAAAGTTTATATACCGCACTTAGCAATCAGAAAATTGCTTTTGCCAGTGAAGATATTGAACTGAGAGAACGTTCAAAAGA
ACTCACCGAACTTAAAAATTATTCTATTACCCCTCATGCCGCTTCATTTACCGATGAGGCCGACCATAACACAATGCAAA
TTTCTATTAAAAACGTATTACAGGAACTGGAGAAAGAGTAA

Upstream 100 bases:

>100_bases
ATTTATTTTTACATACAAAAATGTGGCCCTCATTTCTTACGTATTCTGGTCACTATTCTTGTTTTGAGTCTTGCATTTTC
TTTCTTTGGCCTTTTATAAA

Downstream 100 bases:

>100_bases
TGAAAGAGCTCAAAGGGATTATTACCGCAATGGTAACGCCTTTCGATGAAACGGAAAAAATGGATATCACTGCGGCGAAA
AAAATGGCGCGCTGGTTAGT

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKKIIITPRPFVGKGKVYIDKLKSAGYQVECNNSGGRYSKEELIEKIKDANAIITGNDPLSREVIDQAKNLKVISKYGVG
LDNIDVDYANSKDIVVHKALNANSISVAEMTILMMLSSSRKYVEIESQARNGKDIRLVGYELYQKNLGLIGLGAIGQHVA
HIAHSMGMTITAHDPHIDKSKVPSYIELKSPDEIYQYSDVISLHLPLLDSTRNIINDSVFEKMKSSAILINTARGGLVDE
KSLYTALSNQKIAFASEDIELRERSKELTELKNYSITPHAASFTDEADHNTMQISIKNVLQELEKE

Sequences:

>Translated_306_residues
MKKIIITPRPFVGKGKVYIDKLKSAGYQVECNNSGGRYSKEELIEKIKDANAIITGNDPLSREVIDQAKNLKVISKYGVG
LDNIDVDYANSKDIVVHKALNANSISVAEMTILMMLSSSRKYVEIESQARNGKDIRLVGYELYQKNLGLIGLGAIGQHVA
HIAHSMGMTITAHDPHIDKSKVPSYIELKSPDEIYQYSDVISLHLPLLDSTRNIINDSVFEKMKSSAILINTARGGLVDE
KSLYTALSNQKIAFASEDIELRERSKELTELKNYSITPHAASFTDEADHNTMQISIKNVLQELEKE
>Mature_306_residues
MKKIIITPRPFVGKGKVYIDKLKSAGYQVECNNSGGRYSKEELIEKIKDANAIITGNDPLSREVIDQAKNLKVISKYGVG
LDNIDVDYANSKDIVVHKALNANSISVAEMTILMMLSSSRKYVEIESQARNGKDIRLVGYELYQKNLGLIGLGAIGQHVA
HIAHSMGMTITAHDPHIDKSKVPSYIELKSPDEIYQYSDVISLHLPLLDSTRNIINDSVFEKMKSSAILINTARGGLVDE
KSLYTALSNQKIAFASEDIELRERSKELTELKNYSITPHAASFTDEADHNTMQISIKNVLQELEKE

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=36.078431372549, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=29.4670846394984, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI61743967, Length=302, Percent_Identity=29.1390728476821, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557497, Length=302, Percent_Identity=29.1390728476821, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI145580578, Length=305, Percent_Identity=31.1475409836066, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557499, Length=305, Percent_Identity=31.1475409836066, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580575, Length=269, Percent_Identity=31.9702602230483, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1789279, Length=283, Percent_Identity=31.4487632508834, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=30.8550185873606, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=28.7822878228782, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=25.4752851711027, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=32.129963898917, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=265, Percent_Identity=30.9433962264151, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=289, Percent_Identity=33.5640138408304, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=289, Percent_Identity=32.8719723183391, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324055, Length=235, Percent_Identity=26.3829787234043, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=246, Percent_Identity=28.0487804878049, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921140, Length=257, Percent_Identity=34.2412451361868, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=33.0612244897959, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=33.0612244897959, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=33.0612244897959, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=33.0612244897959, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=33.0612244897959, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28574286, Length=284, Percent_Identity=28.169014084507, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571528, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585516, Length=277, Percent_Identity=25.9927797833935, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34052; Mature: 34052

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIITPRPFVGKGKVYIDKLKSAGYQVECNNSGGRYSKEELIEKIKDANAIITGNDPL
CCEEEECCCCCCCCCCEEEEEHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCC
SREVIDQAKNLKVISKYGVGLDNIDVDYANSKDIVVHKALNANSISVAEMTILMMLSSSR
HHHHHHHHHCCEEEHHHCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
KYVEIESQARNGKDIRLVGYELYQKNLGLIGLGAIGQHVAHIAHSMGMTITAHDPHIDKS
CEEEEECCCCCCCEEEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHCCEEEECCCCCCHH
KVPSYIELKSPDEIYQYSDVISLHLPLLDSTRNIINDSVFEKMKSSAILINTARGGLVDE
HCCCEEEECCCHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
KSLYTALSNQKIAFASEDIELRERSKELTELKNYSITPHAASFTDEADHNTMQISIKNVL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHH
QELEKE
HHHHCC
>Mature Secondary Structure
MKKIIITPRPFVGKGKVYIDKLKSAGYQVECNNSGGRYSKEELIEKIKDANAIITGNDPL
CCEEEECCCCCCCCCCEEEEEHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCC
SREVIDQAKNLKVISKYGVGLDNIDVDYANSKDIVVHKALNANSISVAEMTILMMLSSSR
HHHHHHHHHCCEEEHHHCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
KYVEIESQARNGKDIRLVGYELYQKNLGLIGLGAIGQHVAHIAHSMGMTITAHDPHIDKS
CEEEEECCCCCCCEEEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHCCEEEECCCCCCHH
KVPSYIELKSPDEIYQYSDVISLHLPLLDSTRNIINDSVFEKMKSSAILINTARGGLVDE
HCCCEEEECCCHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
KSLYTALSNQKIAFASEDIELRERSKELTELKNYSITPHAASFTDEADHNTMQISIKNVL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHH
QELEKE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]