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The map label for this gene is hemF [H]

Identifier: 91211774

GI number: 91211774

Start: 2709656

End: 2710558

Strand: Direct

Name: hemF [H]

Synonym: UTI89_C2769

Alternate gene names: 91211774

Gene position: 2709656-2710558 (Clockwise)

Preceding gene: 91211773

Following gene: 91211793

Centisome position: 53.49

GC content: 54.82

Gene sequence:

>903_bases
GTGATGAAACCCGACGCACACCAGGTTAAACAGTTTCTGCTCAACCTTCAGGATACGATTTGTCAGCAGTTGAGCGCCGT
CGATGGCGCAGAATTTGTCGAAGATAGCTGGCAGCGCGAAGCTGGCGGCGGCGGGCGTAGTCGGGTTTTGCGTAATGGTG
GTGTTTTCGAACAGGCAGGCGTCAACTTTTCACATGTCCACGGTGAGGCGATGCCTGCTTCCGCCACCGCTCATCGTCCG
GAACTTGCCGGGCGCAGTTTCGAGGCGATGGGCGTTTCACTGGTAGTGCATCCGCATAATCCGTATGTCCCCACCAGCCA
CGCGAATGTGCGCTTTTTTATTGCCGAAAAGCCGGGTGCAGAGCCCGTCTGGTGGTTTGGCGGCGGCTTCGATTTAACCC
CTTTCTATGGTTTTGAAGAAGACGCCATTCACTGGCACCGCACCGCCCGTGACCTGTGCCTGCCATTTGGCGAAGACGTT
TATCCGCGTTACAAAAAGTGGTGCGACGAATACTTCTACCTCAAACATCGTAACGAACAGCGCGGCATTGGCGGGCTGTT
CTTTGATGATCTGAACACGCCAGATTTCGACCACTGTTTTGCCTTTATGCAGGCGGTAGGCAAAGGCTACACCGACGCTT
ATTTACCAATTGTAGAGCGACGAAAAGCGATGGCCTACGGCGAGCGCGAGCGCAATTTTCAGCTCTACCGTCGCGGTCGT
TATGTCGAGTTCAATCTGGTCTGGGATCGCGGCACGCTGTTTGGCCTGCAAACTGGCGGGCGCACCGAGTCGATCCTGAT
GTCAATGCCGCCACTGGTACGCTGGGAGTATGATTATCAGCCAAAAGATGGCAGCCCGGAAGCGGCTTTAAGTGAGTTTA
TTAAGGTCAGGGATTGGGTGTAA

Upstream 100 bases:

>100_bases
TGCAGCGTTTCGCCAGAAAATCGCCACAGCGATTGCCGAAGGCGTGATCAGTTATTTCCACTGGTTTGACAACCAGAAAG
CACACTCGAGAAAGCGGTAA

Downstream 100 bases:

>100_bases
CTCCCTCACCCCCACTCTCGCATCCGCTGATGCAGCGTCAGTGACGGCTTCTCGGCAAACAGTTGCTGATAATCCGTGGC
AAATTGCCCAAGATGCCAGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MMKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRP
ELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDV
YPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGR
YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV

Sequences:

>Translated_300_residues
MMKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRP
ELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDV
YPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGR
YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
>Mature_300_residues
MMKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRP
ELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDV
YPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGR
YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=303, Percent_Identity=46.8646864686469, Blast_Score=284, Evalue=8e-77,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=98.9966555183946, Blast_Score=619, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=43.8485804416404, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI17864388, Length=304, Percent_Identity=48.0263157894737, Blast_Score=287, Evalue=6e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34435; Mature: 34435

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCHHCC
VNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGA
CCEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCC
EPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQ
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
RGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGR
CCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCC
YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
EEEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCHHCC
VNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGA
CCEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCC
EPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQ
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
RGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGR
CCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCC
YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
EEEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA