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The map label for this gene is adrB [H]

Identifier: 91211032

GI number: 91211032

Start: 1925086

End: 1926714

Strand: Direct

Name: adrB [H]

Synonym: UTI89_C2011

Alternate gene names: 91211032

Gene position: 1925086-1926714 (Clockwise)

Preceding gene: 91211031

Following gene: 91211035

Centisome position: 38.0

GC content: 50.21

Gene sequence:

>1629_bases
TTGTCGCCATACGCTTACAGGGTGGCCCGCATGCAAAAAGCACAACGGATCATTAAAACCTATCGCCGTAATCGAATGAT
TGTTTGTACGATTTGCGCACTCGTTACGCTCGCTTCGACCCTGAGCGTGCGATTTATTTCACAGCGTAACTTAAATCAAC
AACGGGTAGTACAATTCGCCAATCACGCTGTAGAGGAATTAGATAAAGTACTGCTTCCCCTACAGGCAGGTAGCGAAGTC
TTGCTTCCGCTGATTGGTCTGCCCTGCTCTGTCGCCCATTTGCCATTACGTAAACAGGCGGCAAAACTCCAAACTGTGCG
ATCCATTGGCCTGGTGCAAGACGGCACACTTTATTGCTCCAGCATTTTTGGTTATCGCAATGTGCCCGTCGTGGACATTC
TGGCTGAACTTCCTGCACCGCAACCACTTTTACGACTGACGACCGACCGTGCCCTGATAAAAGGCAGTCCGGTTTTGATT
CAATGGACGCCTGCAGCGGGCAGTAGCAATGCTGGGGTCATGGAGATGATTAACATCGACTTACTGACGGCAATGCTCCT
TGAACCACAACTGCCGCAAATCAGTAGCGCCAGCCTGACGGTGGACAGTCGGCATTTGCTCTATGGTAATGGGCTGGTAG
ATTCCCTTCCGCAACCTGAAAACAATGAAAACTATCAGGTTTCTTCGCAACGCTTTCCTTTTACCATTAACGTTAATGGT
CCGGGGGCTACGGCGCTGGCATGGCACTATCTTCCAACACAATTACCGCTGGCGGTGCTGCTAAGTTTACTTGTGGGCTA
TATCGCCTGGCTGGCGACCGCTTACCGAATGAGTTTTTCCCGCGAAATCAATCTGGGCCTGGCGCAACATGAGTTCGAAT
TGTTCTGCCAGCCTTTGCTTAATGCGCGCAGCCAGCAATGTATTGGCGTAGAGATTTTGCTGCGCTGGAACAATCCGCGT
CAGGGCTGGATTTCGCCGGATGTGTTTATTCCTATCGCGGAAGAACATCATTTAATTGTGCCACTGACCCGCTATGTGAT
GGCAGAAACCATTCGTCAGCGCCATGTTTTCCCGATGAGTAGTCAGTTTCATGTTGGCATTAACGTCGCACCCAGCCATT
TTCGCCGTGGTGTGCTGATAAAAGATCTCAATCAGTACTGGTTTAGCGCTCACCCGATTCAGCAACTGATCCTCGAAATC
ACCGAACGCGATGCCTTACTGGATGTTGATTATCGGATTGCCCGCGAGCTACATCGTAAAAACGTCAAACTGGCGATTGA
TGACTTCGGCACCGGCAATAGTTCATTTTCCTGGCTTGAAACATTACGTCCTGACGTGCTGAAAATTGATAAGTCATTTA
CCGCAGCTATAGGTTCTGACGCGGTTAACTCGACGGTGACCGATATCATCATCGCACTGGGGCAAAGACTGAATATTGAA
CTGGTGGCGGAGGGTGTGGAAACGCAAGAACAGGCGAAATATTTGCGCCGTCATGGCGTCCATATTTTGCAAGGGTATTT
GTACGCACAGCCGATGCCACTATGTGATTTTCCCAAATGGCTGGCGGGCAGCCAACCGCCGCCCGCCCGGCATAATGGAC
ATATCACCCCCATTATGCCGTTACGTTAA

Upstream 100 bases:

>100_bases
TACTTCTTATTCGCCCATCTGCAACGGATGGGCGAATTTATTCCCGCTTTCTCGTCTGCTGTAATTTTCCCCACTACACT
TCCACTGTTGCGTCAGGCGT

Downstream 100 bases:

>100_bases
CGCTTACTCATCTTCATCGTGCGCCGGTTGCTCTTTAACAATGCGAACCAGATCAACACGATAATCATTGGCTTCAATGA
TGGTGATATGCAGTGGCCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSPYAYRVARMQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEV
LLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLI
QWTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNG
PGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPR
QGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEI
TERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIE
LVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLCDFPKWLAGSQPPPARHNGHITPIMPLR

Sequences:

>Translated_542_residues
MSPYAYRVARMQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEV
LLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLI
QWTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNG
PGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPR
QGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEI
TERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIE
LVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLCDFPKWLAGSQPPPARHNGHITPIMPLR
>Mature_541_residues
SPYAYRVARMQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVL
LPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQ
WTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGP
GATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQ
GWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEIT
ERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIEL
VAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLCDFPKWLAGSQPPPARHNGHITPIMPLR

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=532, Percent_Identity=99.2481203007519, Blast_Score=1080, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=527, Percent_Identity=29.6015180265655, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI87081845, Length=528, Percent_Identity=27.8409090909091, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=39.2712550607287, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1790496, Length=259, Percent_Identity=35.1351351351351, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081921, Length=261, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081743, Length=327, Percent_Identity=31.1926605504587, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1787541, Length=259, Percent_Identity=30.5019305019305, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI226510982, Length=262, Percent_Identity=31.6793893129771, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788849, Length=239, Percent_Identity=31.3807531380753, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082096, Length=242, Percent_Identity=29.7520661157025, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787055, Length=253, Percent_Identity=30.0395256916996, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 60801; Mature: 60669

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYAYRVARMQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFA
CCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHH
NHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCS
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHH
SIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSNAGVMEMINID
HHCCCCCCCHHHHHHHCCCCCCHHHEECCCCEECCCCEEEEEECCCCCCCCCCHHHHHHH
LLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNG
HHHHHHHCCCCCCCCCCEEEECCCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECC
PGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHH
NARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS
CCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCC
SQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRK
CCEEEEEEECHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHC
NVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIE
CCEEEEECCCCCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
LVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLCDFPKWLAGSQPPPARHNGHITPIMP
EEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
LR
CC
>Mature Secondary Structure 
SPYAYRVARMQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFA
CCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHH
NHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCS
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHH
SIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSNAGVMEMINID
HHCCCCCCCHHHHHHHCCCCCCHHHEECCCCEECCCCEEEEEECCCCCCCCCCHHHHHHH
LLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNG
HHHHHHHCCCCCCCCCCEEEECCCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECC
PGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHH
NARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS
CCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCC
SQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRK
CCEEEEEEECHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHC
NVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIE
CCEEEEECCCCCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
LVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLCDFPKWLAGSQPPPARHNGHITPIMP
EEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
LR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]