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The map label for this gene is dmlA [H]

Identifier: 91211018

GI number: 91211018

Start: 1913293

End: 1913463

Strand: Direct

Name: dmlA [H]

Synonym: UTI89_C1997

Alternate gene names: 91211018

Gene position: 1913293-1913463 (Clockwise)

Preceding gene: 91211012

Following gene: 91211025

Centisome position: 37.77

GC content: 48.54

Gene sequence:

>171_bases
ATGACCACTGGCGGGAAACAGCCTGGCGACATCGATTTTTACGTGGTCCGGAAAAACACCGAAGGCGAATATTCCTCGCT
AGGCGGTAGAGTAAATGAAGGAACAGAGAATGAAGTCGTCATTCAGGAATCGGTATTTACTCGTCGTGGTGTCGAGCGCA
TTTTGCGTTAA

Upstream 100 bases:

>100_bases
ATTCTACCGTTATCCGCACTTTCGCTGACGTCGACAGCTTTGAAACATAAACGGCCCAGACATTCGCTGGCTGGTAATAT
TCCGGTAGCACTTGTACTAA

Downstream 100 bases:

>100_bases
GCTCAAATAAGTTCATTTGAACCGCCTGCTGTTGGATTTGTAGTTTGCCGAAGCCGGACTGAGCGCGCCCAGTCCGGCTT
CGGAAGATTTTACTGTGGAT

Product: hypothetical protein

Products: NA

Alternate protein names: D-malate degradation protein A; D-malate oxidase [H]

Number of amino acids: Translated: 56; Mature: 55

Protein sequence:

>56_residues
MTTGGKQPGDIDFYVVRKNTEGEYSSLGGRVNEGTENEVVIQESVFTRRGVERILR

Sequences:

>Translated_56_residues
MTTGGKQPGDIDFYVVRKNTEGEYSSLGGRVNEGTENEVVIQESVFTRRGVERILR
>Mature_55_residues
TTGGKQPGDIDFYVVRKNTEGEYSSLGGRVNEGTENEVVIQESVFTRRGVERILR

Specific function: Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in th

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Escherichia coli, GI1788101, Length=53, Percent_Identity=92.4528301886792, Blast_Score=106, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.83 [H]

Molecular weight: Translated: 6276; Mature: 6145

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGGKQPGDIDFYVVRKNTEGEYSSLGGRVNEGTENEVVIQESVFTRRGVERILR
CCCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTGGKQPGDIDFYVVRKNTEGEYSSLGGRVNEGTENEVVIQESVFTRRGVERILR
CCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]