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The map label for this gene is yeaP [H]

Identifier: 91211012

GI number: 91211012

Start: 1909837

End: 1910991

Strand: Direct

Name: yeaP [H]

Synonym: UTI89_C1991

Alternate gene names: 91211012

Gene position: 1909837-1910991 (Clockwise)

Preceding gene: 91211009

Following gene: 91211018

Centisome position: 37.7

GC content: 46.49

Gene sequence:

>1155_bases
TTGCAGCACTATTTTTATTACATTCACTCAAAACATATTACGCCTTGTTTCATCTTTGTTGATGATGTTTTATCATGCCT
GCAAAGATTAAATAATCAGCATTTACCCGCCGTATCCTGGAGTTGTTTCGTGTCAGATCAGATTATCGCCCGCGTCTCGC
AATCCCTTGCCAAAGAACAGTCACTGGAAAGTCTGGTTCGACAGCTTCTGGAGATGCTGGAAATGGTCACTGATATGGAG
TCAACCTACCTGACCAAAGTGGATGTCGAAGCGCGCCTGCAGCATATAATGTTTGCCCGTAATAGCCAGAAAATGCACAT
CCCGGAGAATTTTACCGTCTCGTGGGATTACTCGTTATGCAAACGCGCCATTGATGAAAACTGTTTTTTCAGCGATGAAG
TCCCCGACCGTTGGGGCGACTGTGTTGCGGCACGCAATCTTGGCATCACCACATTTCTGAGCACGCCAATTCACTTACCG
GATGGATCATTCTATGGCACGCTTTGCGCCGCCAGCAGTGAGAAGCGCCAGTGGAGTGAACGCGCGGAACAGGTCTTACA
GTTGTTCGCCGGACTGATTGCACAATATATTCAAAAAGAGGCACTGGTTGAACAGCTGCGCGAAGCTAATGCTGCGCTGA
TTGCGCAATCGTATACCGACTCGTTAACTGGGCTACCGAATCGGCGGGCGATTTTTGAAAATCTGACGACGCTGTTTTCT
CTCGCCCGGCATCTTAACCATAAGATAATGATCGCGTTTATCGATCTGGATAACTTCAAATTAATCAATGATCGTTTTGG
TCATAATAGTGGCGATCTGTTTCTCATTCAGGTTGGCGAGCGCCTTAATACGCTCCAGCAAAATGGCGAAGTTATTGGTC
GTCTCGGCGGTGATGAGTTTTTGGTTGTTTCACTGAACAACGAGAATGCGGATATTTCGTCGCTGCGAGAACGTATTCAA
CAACAAATACGCGGAGAATATCACTTAGGTGATGTTGATTTGTATTATCCTGGTGCCAGTCTTGGCATAGTAGAAGTCGA
TCCTGAAACGACCGATGCAGACAGTGCCCTGCATGCTGCCGATATCGCGATGTATCAGGAGAAAAAACATAAACAGAAAA
CACCTTTTGTCACGCATTCAGCGCTACATTCCTGA

Upstream 100 bases:

>100_bases
CCAGCCAGGACCAGCAAGCAAGGCAGAACAAAACTGATAATTTTCATTTATTGATCTCACATATTTATCCAAGCTTAGAG
TATCGCGGTATCGTTTTGTT

Downstream 100 bases:

>100_bases
GGCGTATTCACATCCTTTTGATTGGTGATAACATGCGAATCGGTATTATTTTTCCGGTTGTAATCTTTATTACAGCGGTC
GTATTTTTAGCATGGTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MQHYFYYIHSKHITPCFIFVDDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDME
STYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLP
DGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQ
QQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS

Sequences:

>Translated_384_residues
MQHYFYYIHSKHITPCFIFVDDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDME
STYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLP
DGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQ
QQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>Mature_384_residues
MQHYFYYIHSKHITPCFIFVDDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDME
STYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLP
DGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQ
QQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=341, Percent_Identity=98.533724340176, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI1787541, Length=167, Percent_Identity=32.9341317365269, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082007, Length=193, Percent_Identity=31.0880829015544, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788381, Length=172, Percent_Identity=30.8139534883721, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786584, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788956, Length=101, Percent_Identity=41.5841584158416, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787816, Length=162, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 43679; Mature: 43679

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHYFYYIHSKHITPCFIFVDDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQ
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
HHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCCCEECCCCCEEEECHHHH
KRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
HHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEECCCCCCEEHEECCCCHHHHHHH
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHCCCCCHHHHHHHHHHHHH
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
HHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHHHHHHCCCEEEEECCCCE
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
EEEEECCCCCCHHHHHHHHHHHHCCCEECCCEEEEECCCCEEEEEECCCCCCCCHHHHHH
DIAMYQEKKHKQKTPFVTHSALHS
HHHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure
MQHYFYYIHSKHITPCFIFVDDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQ
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
HHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCCCEECCCCCEEEECHHHH
KRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
HHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEECCCCCCEEHEECCCCHHHHHHH
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHCCCCCHHHHHHHHHHHHH
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
HHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHHHHHHCCCEEEEECCCCE
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
EEEEECCCCCCHHHHHHHHHHHHCCCEECCCEEEEECCCCEEEEEECCCCCCCCHHHHHH
DIAMYQEKKHKQKTPFVTHSALHS
HHHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]