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The map label for this gene is manA [H]

Identifier: 91210824

GI number: 91210824

Start: 1729006

End: 1730181

Strand: Direct

Name: manA [H]

Synonym: UTI89_C1801

Alternate gene names: 91210824

Gene position: 1729006-1730181 (Clockwise)

Preceding gene: 91210821

Following gene: 91210825

Centisome position: 34.13

GC content: 50.85

Gene sequence:

>1176_bases
ATGCAAAAACTCATTAACTCAGTGCAAAACTATGCCTGGGGCAGCAAAACGGCGTTGACTGAACTTTATGGTATGGAAAA
TCCGTCCAGCCAGCCGATGGCCGAGTTGTGGATGGGCGCGCATCCAAAGAGCAGTTCACGTGTGCACGATGCCACAGGAG
ATATCGTTTCACTGCGTGATGTGATTGAGAGTGATAAAGCGACTCTTTTGGGAGATGCCGTTGCCAAACGCTTTGGCGAG
TTGCCTTTCCTGTTCAAAGTATTATGCGCAGCCCAGCCGCTCTCCATTCAGGTTCATCCAAACAAACGCAATTCTGAAAT
CGGTTTTGCCAAAGAAAATGCTGCAGGTATTCCGATGGATGCCGCTGAGCGTAACTATAAAGATCCTAATCACAAGCCTG
AGCTGGTTTTCGCCCTGACCCCTTTCCTCGCGATGAACGCGTTTCGTGAGTTTTCCGAGATTGTCTCCCTGCTCCAGCCG
GTCGCAGGTGCACATCCGGCGATTGCTCACTTTTTACAACAGCCTGATGCCGAACGTTTAAGCGAACTGTTCGCCAGCCT
GTTGAATATGCAGGGTGAAGAAAAATCCCGCGCGCTGGCGATTTTAAAATCGGCCCTCGACAGCCAGCAGGGTGAACCAT
GGCAAACGATTCGTTTAATTTCTGAATTTTACCCGGAAGACAGCGGTCTGTTCTCCCCGCTGTTGCTGAATGTGGTGAAA
TTGAATCCTGGCGAAGCGATGTTCCTGTTCGCTGAAACACCGCACGCTTACCTGCAAGGCGTGGCGCTGGAAGTGATGGC
GAACTCCGATAACGTGCTGCGTGCAGGTCTGACGCCTAAATACATTGATATTCCGGAACTGGTTGCCAACGTGAAGTTCG
AAGCCAAACCGGCTAACCAGTTGTTGACCCAGCCGGTGAAACAAGGTGCAGAACTGGACTTCCCGATTCCTGTGGATGAT
TTTGCCTTCTCGTTGCATGACCTTAGTGATAAAGAAACCACCATCAGCCAGCAGAGTGCCGCCATTTTGTTCTGCGTCGA
AGGCGATGCAACGCTGTGTAAAGGTTCTCAGCAGTTACAGCTTAAACCGGGTGAATCAGCGTTTATTGCCGCCAACGAAT
CACCGGTGACTGTCAAAGGCCACGGCCGTTTAGCGCGTGTTTACAACAAGCTGTAA

Upstream 100 bases:

>100_bases
AAACTGAGACTAGTACGACTTTTTGCGGCTCCAGGTTACTTCCCGTAGGATTCTTGCTTTAATAGCGGGATTAATTTCCA
CATTAAAACAGGGATTGATC

Downstream 100 bases:

>100_bases
GAGCTTACTGAAAAAATTAACATCTCTTGCTAAGCTTATTAAAGGCTTATAACACCTTCAGGCGGCCAGTCCGCCTGATT
TCATTTTATGGATAATCATT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVHDATGDIVSLRDVIESDKATLLGDAVAKRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQP
VAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDD
FAFSLHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL

Sequences:

>Translated_391_residues
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVHDATGDIVSLRDVIESDKATLLGDAVAKRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQP
VAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDD
FAFSLHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL
>Mature_391_residues
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVHDATGDIVSLRDVIESDKATLLGDAVAKRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQP
VAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDD
FAFSLHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=403, Percent_Identity=34.4913151364764, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=98.2097186700767, Blast_Score=785, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997620, Length=394, Percent_Identity=31.2182741116751, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17557650, Length=419, Percent_Identity=28.8782816229117, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320839, Length=419, Percent_Identity=31.7422434367542, Blast_Score=179, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21356061, Length=400, Percent_Identity=32, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42796; Mature: 42796

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVHDATGDIVSLRD
CHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
VIESDKATLLGDAVAKRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMD
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPDAERL
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
SELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQ
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCCCCCHHH
LLTQPVKQGAELDFPIPVDDFAFSLHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQ
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCHHHHCCCCEEE
LKPGESAFIAANESPVTVKGHGRLARVYNKL
ECCCCCEEEEECCCCEEEECCCHHHHHHHCC
>Mature Secondary Structure
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVHDATGDIVSLRD
CHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
VIESDKATLLGDAVAKRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMD
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPDAERL
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
SELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQ
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCCCCCHHH
LLTQPVKQGAELDFPIPVDDFAFSLHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQ
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCHHHHCCCCEEE
LKPGESAFIAANESPVTVKGHGRLARVYNKL
ECCCCCEEEEECCCCEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]