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The map label for this gene is hemA [H]

Identifier: 91210431

GI number: 91210431

Start: 1338833

End: 1340287

Strand: Direct

Name: hemA [H]

Synonym: UTI89_C1404

Alternate gene names: 91210431

Gene position: 1338833-1340287 (Clockwise)

Preceding gene: 91210426

Following gene: 91210432

Centisome position: 26.43

GC content: 51.96

Gene sequence:

>1455_bases
TTGAGATACGTTGCAGTTATAACCCTTAATGCTAGCGTTACCGTTAGCCATCGTCTATGTTCACGTTGTCTTAATTGCCA
GAATCTAACGGCTTTCGGCAATTACTCCAAAAGGGGGCGCTCTCTTTTATTGATCTTACGCATCCTGTATGATGCAAGCA
GACTAACCCTATCAACGTTGGTATTATTTCCCGCAGACATGACCCTTTTAGCACTCGGTATCAACCATAAAACGGCACCT
GTATCGCTGCGAGAACGTGTATCGTTTTCGCCGGATAAGCTCGATCAGGCGCTTGACAGCCTGCTTGCGCAGCCGATGGT
GCAGGGCGGTGTGGTGCTGTCGACGTGTAACCGCACAGAACTTTATCTCAGCGTTGAAGAACGGGATGACCTGCAAGAGG
CGCTCATTCGCTGGTTGTGTGATTACCATAATCTCAACGAAGACGATCTGCGTAATAGCCTCTACTGGCATCAGGATAAC
GATGCGGTCAGTCATTTAATGCGCGTTGCCAGTGGGCTTGATTCTCTCGTCCTTGGCGAGCCGCAGATCCTCGGTCAGGT
TAAAAAAGCGTTTGCCGATTCGCAAAAAGGTCATATGAAGGCCAGCGAACTGGAACGCATGTTTCAGAAATCTTTCTCTG
TGGCGAAACGCGTTCGCACTGAAACAGATATCGGTGCCAGTGCTGTGTCTGTCGCTTTTGCGGCTTGTACGCTGGCGCGG
CAGATCTTTGAATCGCTCTCTACGGTGACGGTACTGCTGGTTGGCGCGGGCGAAACCATCGAGCTGGTGGCACGTCATCT
GCGCGAACACAAAGTACAGAAGATGATTATCGCCAATCGCACTCGCGAACGTGCCCAAATTCTGGCAGATGAGGTTGGCG
CGGAAGTGATTGCCCTGAGTGATATCGACGAACGTCTGCGCGAAGCCGATATCATCATCAGTTCCACCGCCAGCCCGTTG
CCGATTATCGGTAAAGGCATGGTGGAGCGCGCATTAAAAAGCCGTCGCAATCAACCAATGCTGCTGGTGGATATTGCCGT
TCCGCGCGATGTTGAGCCGGAAGTTGGTAAACTGGCGAATGCTTATCTTTATAGCGTTGACGATCTGCAAAGCATTATTT
CGCACAACCTGGCGCAACGGAAAGCTGCTGCTGTGGAGGCGGAAACTATCGTCGCCCAGGAGGCCAGTGAATTTATGGCA
TGGCTTCGAGCACAAAGCGCCAGCGAAACTATTCGCGATTATCGTAGCCAGGCAGAGCAGGTTCGTGATGAGTTAACTGC
TAAAGCGTTAGCGGCCCTTGAACAGGGCGGCGATGCGCAAACCATTATGCAGGATCTGGCATGGAAACTGACTAACCGCC
TGATCCATGCACCAACAAAATCACTTCAACAGGCCGCCCGTGACGGGGATAACGAACGCCTGAATATTCTGCGCGACAGC
CTCGGGCTGGAGTAG

Upstream 100 bases:

>100_bases
CTTTGGGCGTGGTAACGGAACAGGCAGTGAGCACAAGAGCAGCCAGCGGTAGCAGGCGGATAAGACGAAAATCGGGCAGG
GGCATAATAATGACAAGTCC

Downstream 100 bases:

>100_bases
CAGTACATCATTTTCTTTTTTTACAGGGTGCATTTACGCCTATGAAGCCTTCTATCGTTGCCAAACTGGAAGCCCTGCAT
GAACGCCATGAAGAAGTTCA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MRYVAVITLNASVTVSHRLCSRCLNCQNLTAFGNYSKRGRSLLLILRILYDASRLTLSTLVLFPADMTLLALGINHKTAP
VSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDN
DAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLAR
QIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPL
PIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMA
WLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDS
LGLE

Sequences:

>Translated_484_residues
MRYVAVITLNASVTVSHRLCSRCLNCQNLTAFGNYSKRGRSLLLILRILYDASRLTLSTLVLFPADMTLLALGINHKTAP
VSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDN
DAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLAR
QIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPL
PIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMA
WLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDS
LGLE
>Mature_484_residues
MRYVAVITLNASVTVSHRLCSRCLNCQNLTAFGNYSKRGRSLLLILRILYDASRLTLSTLVLFPADMTLLALGINHKTAP
VSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDN
DAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLAR
QIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPL
PIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMA
WLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDS
LGLE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=98.3253588516746, Blast_Score=836, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 53680; Mature: 53680

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVAVITLNASVTVSHRLCSRCLNCQNLTAFGNYSKRGRSLLLILRILYDASRLTLSTL
CCEEEEEEECCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLFPADMTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTE
HHHCCCHHHEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEE
LYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGE
EEEEEHHHCCHHHHHHHHHHHHCCCCHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHCCC
PQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLAR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALS
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEH
DIDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLAN
HHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
AYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
LGLE
HCCC
>Mature Secondary Structure
MRYVAVITLNASVTVSHRLCSRCLNCQNLTAFGNYSKRGRSLLLILRILYDASRLTLSTL
CCEEEEEEECCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLFPADMTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTE
HHHCCCHHHEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEE
LYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGE
EEEEEHHHCCHHHHHHHHHHHHCCCCHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHCCC
PQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLAR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALS
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEH
DIDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLAN
HHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
AYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
LGLE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA