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The map label for this gene is hemH

Identifier: 89898676

GI number: 89898676

Start: 1021716

End: 1022672

Strand: Direct

Name: hemH

Synonym: CF0869

Alternate gene names: 89898676

Gene position: 1021716-1022672 (Clockwise)

Preceding gene: 89898673

Following gene: 89898682

Centisome position: 87.61

GC content: 39.18

Gene sequence:

>957_bases
ATGGTTTCTGTGTACTTATTAGCAAATTTTGGCGGTCCTCGTCATGCTAGTGACATTGAAGTTTTTCTTACTTCATTACT
TACAGATCGTGATGTTACTGGGAAGTTTCTTCCACCTTTCATTCACAAACGTTTATTTTCATTCATTGCTAAAAAACGTG
TTGCTAAAGTTCTCCCCCAGTACAACTGTATTGGTGGATTTTCTCCTATATATCGAGATACAGAAGACCTTGCGGACACC
CTATCCTTGTACTTAGATGCCCCCGTAATTACCTTTCACCGTTATTTACCTGATACGCACCAGCTTACAGTTCAGAGATT
GAAAGCCTTTGGAGATTGTCCCGTTATTGGTGTTCCCCTCTTTCCTCATTTTACTTATTCTGTGACAGGAAGTATTGTGA
GGTTTATTCATGCTCACCTTCCGTTACTAAATATCTCTTGGATATCCCATTTTGGAAATCACCCTCAGTTTATTTTCTGC
ATGATTGATCATATTCTGAAATTTTTACAATCCCACGATATCTCCATACACGACTGCTGTCTATTATTTTCTGCCCACGG
GCTTCCTATGAGATATATAAATAAAGGCGACCCATACAACAAGCATTGTGAAAAATCTTTCAAAACAATTTCTGAAAGAT
TACCTAATATAGAAACTCACCTGTGTTATCAGTCTAAATTCGGTCCGGGGAGATGGCTAACGCCATCAACAAAAGACGTA
TGCGAGACGTTAAAGACAGATAAAACATACGTTCTTATCGTGCCTTTTGGATTTACTTCAGATCACATCGAAACTCTTTA
CGAAATAGAAAAGGAGTACATCCCGATACTTAAAGCTAGGGAATATAGAGCTTTACGCGTACCAGCGATTTACCAGTCCC
CCGAATGGGCAGCATCTTTAGCTACAATCATTCAAAGTACACCACGTGCGGAGAAGGAAAGCTTAATAAAACCGTAA

Upstream 100 bases:

>100_bases
TCATGTATCTTAAAAACTCATCTTAACTTTATGGGAAATTATGCAACTAATTGTTTTAATGCAATAGCTCCAATATTATT
AAATAATAAAGCTTGTTACC

Downstream 100 bases:

>100_bases
CAACTTAAGGAAGACGGTATTGCTGTTTGATAGCTTGATACTTACCGGAGCGAATGCTTTTTACTAGTCCCATATTAAAA
CCCTCTAATAGGTTATCCTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MVSVYLLANFGGPRHASDIEVFLTSLLTDRDVTGKFLPPFIHKRLFSFIAKKRVAKVLPQYNCIGGFSPIYRDTEDLADT
LSLYLDAPVITFHRYLPDTHQLTVQRLKAFGDCPVIGVPLFPHFTYSVTGSIVRFIHAHLPLLNISWISHFGNHPQFIFC
MIDHILKFLQSHDISIHDCCLLFSAHGLPMRYINKGDPYNKHCEKSFKTISERLPNIETHLCYQSKFGPGRWLTPSTKDV
CETLKTDKTYVLIVPFGFTSDHIETLYEIEKEYIPILKAREYRALRVPAIYQSPEWAASLATIIQSTPRAEKESLIKP

Sequences:

>Translated_318_residues
MVSVYLLANFGGPRHASDIEVFLTSLLTDRDVTGKFLPPFIHKRLFSFIAKKRVAKVLPQYNCIGGFSPIYRDTEDLADT
LSLYLDAPVITFHRYLPDTHQLTVQRLKAFGDCPVIGVPLFPHFTYSVTGSIVRFIHAHLPLLNISWISHFGNHPQFIFC
MIDHILKFLQSHDISIHDCCLLFSAHGLPMRYINKGDPYNKHCEKSFKTISERLPNIETHLCYQSKFGPGRWLTPSTKDV
CETLKTDKTYVLIVPFGFTSDHIETLYEIEKEYIPILKAREYRALRVPAIYQSPEWAASLATIIQSTPRAEKESLIKP
>Mature_318_residues
MVSVYLLANFGGPRHASDIEVFLTSLLTDRDVTGKFLPPFIHKRLFSFIAKKRVAKVLPQYNCIGGFSPIYRDTEDLADT
LSLYLDAPVITFHRYLPDTHQLTVQRLKAFGDCPVIGVPLFPHFTYSVTGSIVRFIHAHLPLLNISWISHFGNHPQFIFC
MIDHILKFLQSHDISIHDCCLLFSAHGLPMRYINKGDPYNKHCEKSFKTISERLPNIETHLCYQSKFGPGRWLTPSTKDV
CETLKTDKTYVLIVPFGFTSDHIETLYEIEKEYIPILKAREYRALRVPAIYQSPEWAASLATIIQSTPRAEKESLIKP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=324, Percent_Identity=34.5679012345679, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=34.5679012345679, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786681, Length=313, Percent_Identity=23.6421725239617, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=298, Percent_Identity=31.8791946308725, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17864156, Length=291, Percent_Identity=30.2405498281787, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24651774, Length=259, Percent_Identity=29.3436293436293, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552018, Length=147, Percent_Identity=32.6530612244898, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_CHLFF (Q252Z7)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_515786.1
- ProteinModelPortal:   Q252Z7
- SMR:   Q252Z7
- STRING:   Q252Z7
- GeneID:   3958490
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0869
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   RLPNIET
- ProtClustDB:   PRK00035
- BioCyc:   CFEL264202:CF0869-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36427; Mature: 36427

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVYLLANFGGPRHASDIEVFLTSLLTDRDVTGKFLPPFIHKRLFSFIAKKRVAKVLPQ
CEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
YNCIGGFSPIYRDTEDLADTLSLYLDAPVITFHRYLPDTHQLTVQRLKAFGDCPVIGVPL
CCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCC
FPHFTYSVTGSIVRFIHAHLPLLNISWISHFGNHPQFIFCMIDHILKFLQSHDISIHDCC
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
LLFSAHGLPMRYINKGDPYNKHCEKSFKTISERLPNIETHLCYQSKFGPGRWLTPSTKDV
HHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCCHHHH
CETLKTDKTYVLIVPFGFTSDHIETLYEIEKEYIPILKAREYRALRVPAIYQSPEWAASL
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEECCCHHHHHH
ATIIQSTPRAEKESLIKP
HHHHHCCCCHHHHHCCCC
>Mature Secondary Structure
MVSVYLLANFGGPRHASDIEVFLTSLLTDRDVTGKFLPPFIHKRLFSFIAKKRVAKVLPQ
CEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
YNCIGGFSPIYRDTEDLADTLSLYLDAPVITFHRYLPDTHQLTVQRLKAFGDCPVIGVPL
CCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCC
FPHFTYSVTGSIVRFIHAHLPLLNISWISHFGNHPQFIFCMIDHILKFLQSHDISIHDCC
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
LLFSAHGLPMRYINKGDPYNKHCEKSFKTISERLPNIETHLCYQSKFGPGRWLTPSTKDV
HHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCCHHHH
CETLKTDKTYVLIVPFGFTSDHIETLYEIEKEYIPILKAREYRALRVPAIYQSPEWAASL
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEECCCHHHHHH
ATIIQSTPRAEKESLIKP
HHHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA