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The map label for this gene is tlyC3 [C]

Identifier: 89898579

GI number: 89898579

Start: 915734

End: 916873

Strand: Direct

Name: tlyC3 [C]

Synonym: CF0772

Alternate gene names: 89898579

Gene position: 915734-916873 (Clockwise)

Preceding gene: 89898578

Following gene: 89898580

Centisome position: 78.52

GC content: 39.82

Gene sequence:

>1140_bases
ATGCGCTTCTATCAGATTAAAATGCTTGATTTCCTATTGGCAATTTCTCTCCTTGTTCTCCTATTTTCCACAGCCCTAAC
ACAAAAATCAGTCAAAACACAAGAGGATGATACACTCCACCGCCATCCTAGTCAGTCCAATACACCGGCTCTTCTTGCCT
CTGTCTTGCTCTGCTTATATGGAATCATAGGCGTTTCTATCTATTCTCAATACAAATTTACAACTAAAGGCTTAACTCAA
TGCTTCTGGGCCGCTTATGTGCTTGCTGCTCCTTTAGCCTACGGGTTCCTTCCCTACAGCATAAAACTCCATAAAGGGAT
TGTCTCAGCACTGTGTTGTATTTCTTCTTTACTTCAAGCATTTTTCCTTCCTCTTCAACGCTCTATTCATAACGAAGAAA
AGGATCCCAAACCCTCAAGCTCAGAAATGGAAAATCAAATGACAGAAGCAATATCGTCTTTTGATAAATTGATCGTGAGG
GAAATTATGATCCCTAAGGTAGATATCTTTGCAATACAAGAAGATACCCCTATTCGCAATGCTTTTCCAGCTATCATAGA
AGAAGGCTATAGCCGAATTCCTCTATACAAGAAAAATATCGACAACATCACTGGTATACTCCTAGTCAAAGATTTACTAG
CTAACCCCCAGTCAGCTAATTCCTCTCAACCAGTATCTTCAGTAGCCAAATCCCCCATATACGCCCCTGAAATTAAAAAA
GTCTCGTCATTACTTCAGGAGTTTCGTCAAAAACATCGCCACCTAGCGATTGTAGTCAATGAATATGGTGTTACCGAAGG
GATCATCAGTATGGAAGATATTATCGAAGAAATTTTCGGAGAAATCGCCGATGAGTATGACGTCCAAGAGGATATTCCCT
ATAAAAAAGTCGGAAATTCGTGGATTGTTGACGGTCGTATGAATATCTCCGATGCCGAAGAATATTTTAATTTAAAAATT
CATCACGAAAATAGTTACGATACCCTAGGAGGCCATGTTTTTCATAAGGTTGGCGCCGTCCCACAAAAAGGGATGAAAAT
TCATCACGAAAACTTTGATATAGAAATTATCACCTGCTCAGAACGTAGCGTTGGGAAACTCAAAATCACCCCAAGAAAAA
AGAAGTTCTCCCCTTCGTAA

Upstream 100 bases:

>100_bases
TCCCTCCTGCACATGCTGGGATACGATGACCAAACTCCTGAGGAAAGAAAAAAAATGAGAGTTAAAGAAAATCAAGCGCT
ATGTATGTTAAGAGAAAAAC

Downstream 100 bases:

>100_bases
CTTCTTCCAATATACAGAGAAACAAAAGAATAGAAAAATCTCTTTGCAAAAAACCTAAAGATTTACGAGAGTTAGGTCTT
GAGAAATCACTATAGGTTTG

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MRFYQIKMLDFLLAISLLVLLFSTALTQKSVKTQEDDTLHRHPSQSNTPALLASVLLCLYGIIGVSIYSQYKFTTKGLTQ
CFWAAYVLAAPLAYGFLPYSIKLHKGIVSALCCISSLLQAFFLPLQRSIHNEEKDPKPSSSEMENQMTEAISSFDKLIVR
EIMIPKVDIFAIQEDTPIRNAFPAIIEEGYSRIPLYKKNIDNITGILLVKDLLANPQSANSSQPVSSVAKSPIYAPEIKK
VSSLLQEFRQKHRHLAIVVNEYGVTEGIISMEDIIEEIFGEIADEYDVQEDIPYKKVGNSWIVDGRMNISDAEEYFNLKI
HHENSYDTLGGHVFHKVGAVPQKGMKIHHENFDIEIITCSERSVGKLKITPRKKKFSPS

Sequences:

>Translated_379_residues
MRFYQIKMLDFLLAISLLVLLFSTALTQKSVKTQEDDTLHRHPSQSNTPALLASVLLCLYGIIGVSIYSQYKFTTKGLTQ
CFWAAYVLAAPLAYGFLPYSIKLHKGIVSALCCISSLLQAFFLPLQRSIHNEEKDPKPSSSEMENQMTEAISSFDKLIVR
EIMIPKVDIFAIQEDTPIRNAFPAIIEEGYSRIPLYKKNIDNITGILLVKDLLANPQSANSSQPVSSVAKSPIYAPEIKK
VSSLLQEFRQKHRHLAIVVNEYGVTEGIISMEDIIEEIFGEIADEYDVQEDIPYKKVGNSWIVDGRMNISDAEEYFNLKI
HHENSYDTLGGHVFHKVGAVPQKGMKIHHENFDIEIITCSERSVGKLKITPRKKKFSPS
>Mature_379_residues
MRFYQIKMLDFLLAISLLVLLFSTALTQKSVKTQEDDTLHRHPSQSNTPALLASVLLCLYGIIGVSIYSQYKFTTKGLTQ
CFWAAYVLAAPLAYGFLPYSIKLHKGIVSALCCISSLLQAFFLPLQRSIHNEEKDPKPSSSEMENQMTEAISSFDKLIVR
EIMIPKVDIFAIQEDTPIRNAFPAIIEEGYSRIPLYKKNIDNITGILLVKDLLANPQSANSSQPVSSVAKSPIYAPEIKK
VSSLLQEFRQKHRHLAIVVNEYGVTEGIISMEDIIEEIFGEIADEYDVQEDIPYKKVGNSWIVDGRMNISDAEEYFNLKI
HHENSYDTLGGHVFHKVGAVPQKGMKIHHENFDIEIITCSERSVGKLKITPRKKKFSPS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=193, Percent_Identity=30.0518134715026, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI94681046, Length=203, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI40068053, Length=150, Percent_Identity=34, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40068055, Length=150, Percent_Identity=34, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786879, Length=225, Percent_Identity=32, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI145693175, Length=360, Percent_Identity=23.6111111111111, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082033, Length=237, Percent_Identity=24.8945147679325, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790664, Length=233, Percent_Identity=23.175965665236, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788119, Length=252, Percent_Identity=23.015873015873, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539402, Length=170, Percent_Identity=30, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 42743; Mature: 42743

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFYQIKMLDFLLAISLLVLLFSTALTQKSVKTQEDDTLHRHPSQSNTPALLASVLLCLY
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHH
GIIGVSIYSQYKFTTKGLTQCFWAAYVLAAPLAYGFLPYSIKLHKGIVSALCCISSLLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
FFLPLQRSIHNEEKDPKPSSSEMENQMTEAISSFDKLIVREIMIPKVDIFAIQEDTPIRN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
AFPAIIEEGYSRIPLYKKNIDNITGILLVKDLLANPQSANSSQPVSSVAKSPIYAPEIKK
HHHHHHHCCHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHH
VSSLLQEFRQKHRHLAIVVNEYGVTEGIISMEDIIEEIFGEIADEYDVQEDIPYKKVGNS
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCC
WIVDGRMNISDAEEYFNLKIHHENSYDTLGGHVFHKVGAVPQKGMKIHHENFDIEIITCS
EEEECCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEC
ERSVGKLKITPRKKKFSPS
CCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MRFYQIKMLDFLLAISLLVLLFSTALTQKSVKTQEDDTLHRHPSQSNTPALLASVLLCLY
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHH
GIIGVSIYSQYKFTTKGLTQCFWAAYVLAAPLAYGFLPYSIKLHKGIVSALCCISSLLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
FFLPLQRSIHNEEKDPKPSSSEMENQMTEAISSFDKLIVREIMIPKVDIFAIQEDTPIRN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
AFPAIIEEGYSRIPLYKKNIDNITGILLVKDLLANPQSANSSQPVSSVAKSPIYAPEIKK
HHHHHHHCCHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHH
VSSLLQEFRQKHRHLAIVVNEYGVTEGIISMEDIIEEIFGEIADEYDVQEDIPYKKVGNS
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCC
WIVDGRMNISDAEEYFNLKIHHENSYDTLGGHVFHKVGAVPQKGMKIHHENFDIEIITCS
EEEECCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEC
ERSVGKLKITPRKKKFSPS
CCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]