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The map label for this gene is dnaX2 [H]

Identifier: 89898478

GI number: 89898478

Start: 775596

End: 776933

Strand: Direct

Name: dnaX2 [H]

Synonym: CF0671

Alternate gene names: 89898478

Gene position: 775596-776933 (Clockwise)

Preceding gene: 89898476

Following gene: 89898479

Centisome position: 66.5

GC content: 39.09

Gene sequence:

>1338_bases
ATGACGCCTGCAACATACCAAGTTTCTTCTAGAAAGTATCGTCCCCAAACCTTTTCCGAAATTCTTGGGCAAGATGCTGT
GGTTACTGTTTTAAAAAATGCCCTGCAGTTTCAACGTGTAGCGCATGCGTACTTATTCTCAGGAATTCGAGGAACGGGAA
AAACAACCTTAGCAAGAATTTTTGCAAAAGCGTTAAATTGCACAGAGCCAACTGCGAATAATGAGCCTTGCAATCGTTGT
TGTATATGTAAAGAAATCTCTTCAGGGACCTCTTTAGACGTTATAGAAATAGATGGAGCTTCACATAGAGGTATCGAAGA
CATCCGTCAGATCAACGAAACAGTTCTTTTTACTCCTGCCAAATCGCAATATAAAATCTATATCATAGATGAAGTGCACA
TGTTGACAAAAGAGGCTTTTAACTCCTTGTTAAAGACTCTAGAAGAGCCTCCCAGCCACGTAAAATTTTTCCTAGCAACT
ACAGAAAATTATAAAATACCAGGGACTATTTTAAGTCGTTGTCAAAAAATGCACTTAAAAAGAATTCCTGAGACGATGAT
TGTGGATAAGCTAGAATCCATATCTCAAGATATTTCTCTAGAGACTTCTCGAGAAGCTCTTCTTCCTATTGCTAGAGCGG
CTCAGGGAAGTCTACGCGATGCAGAATCTCTTTACGATTACGTAATAGGGTTATTTCCCAAATCTCTATCTCCGGAATCT
GTTACAGATGCGTTAGGTTTAGTATCGCAAGATACCCTATGCAATTTAGCAGAATGTATCCGCACACAAAAATATGTCGA
TGCTTTACTTCCCATAACTACAGCGCTAAATTCTGGGGTTGCTCCTACTGCTTTTCTTCATGATCTTACGGTTTTTTATC
GCGATATACTCCTCAGCAAAGATCAGGAAAATTCCCCTCTAGCGGCAACAGCAAAGCTCTATTCCAGAGAGTGTTTGCTA
GAAATCATCGATTTTCTTGGAGAATCTGCGAAACACCTACAACAAACCATTTTCGAAAAAACATTTTTAGAAACAGTAAT
TATTCATCTAATTCGGATATGCCAACGTCCTTCTTTAGAAACGTTGTTTTCTCAACTTAAAGCCTCAGCTTTTGACGCCC
CGAGAAATACTTCCCAGCAGCAAGAACAGCCTAAACCTATTATACAACCAGAAAAGCGTTATGAAGAGCAGAGTTTCTTA
TCCTCATCTTCGAAGTCCTCTGATCCTCAAGACCTACCTAAAAAAGAAGCTTCCACTTCTTTAGTGGGATCGGCTACTAT
AGATACTCTTTTACAATTTGCTGTTGTTGAGTTTTCTGGAATTTTAACTAAGGAGTAA

Upstream 100 bases:

>100_bases
ACGAGAACATTTCTGGGACAACCAATCTAAAAATCTCAGAAAAAATAGTCACCTGAATTAAATAAAAATATCCTCGTAAT
AAATTTTATAGGAAAAACAA

Downstream 100 bases:

>100_bases
ATGCATGGGCAGTGGATATGCCAAAAAGAAAAAAGAAGCAAAAATCATGGAGCAACAATTCTTAGAAATGGAAGCTTCTC
TAGAAAAAAAACGCTACGAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTPATYQVSSRKYRPQTFSEILGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARIFAKALNCTEPTANNEPCNRC
CICKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPAKSQYKIYIIDEVHMLTKEAFNSLLKTLEEPPSHVKFFLAT
TENYKIPGTILSRCQKMHLKRIPETMIVDKLESISQDISLETSREALLPIARAAQGSLRDAESLYDYVIGLFPKSLSPES
VTDALGLVSQDTLCNLAECIRTQKYVDALLPITTALNSGVAPTAFLHDLTVFYRDILLSKDQENSPLAATAKLYSRECLL
EIIDFLGESAKHLQQTIFEKTFLETVIIHLIRICQRPSLETLFSQLKASAFDAPRNTSQQQEQPKPIIQPEKRYEEQSFL
SSSSKSSDPQDLPKKEASTSLVGSATIDTLLQFAVVEFSGILTKE

Sequences:

>Translated_445_residues
MTPATYQVSSRKYRPQTFSEILGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARIFAKALNCTEPTANNEPCNRC
CICKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPAKSQYKIYIIDEVHMLTKEAFNSLLKTLEEPPSHVKFFLAT
TENYKIPGTILSRCQKMHLKRIPETMIVDKLESISQDISLETSREALLPIARAAQGSLRDAESLYDYVIGLFPKSLSPES
VTDALGLVSQDTLCNLAECIRTQKYVDALLPITTALNSGVAPTAFLHDLTVFYRDILLSKDQENSPLAATAKLYSRECLL
EIIDFLGESAKHLQQTIFEKTFLETVIIHLIRICQRPSLETLFSQLKASAFDAPRNTSQQQEQPKPIIQPEKRYEEQSFL
SSSSKSSDPQDLPKKEASTSLVGSATIDTLLQFAVVEFSGILTKE
>Mature_444_residues
TPATYQVSSRKYRPQTFSEILGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARIFAKALNCTEPTANNEPCNRCC
ICKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPAKSQYKIYIIDEVHMLTKEAFNSLLKTLEEPPSHVKFFLATT
ENYKIPGTILSRCQKMHLKRIPETMIVDKLESISQDISLETSREALLPIARAAQGSLRDAESLYDYVIGLFPKSLSPESV
TDALGLVSQDTLCNLAECIRTQKYVDALLPITTALNSGVAPTAFLHDLTVFYRDILLSKDQENSPLAATAKLYSRECLLE
IIDFLGESAKHLQQTIFEKTFLETVIIHLIRICQRPSLETLFSQLKASAFDAPRNTSQQQEQPKPIIQPEKRYEEQSFLS
SSSKSSDPQDLPKKEASTSLVGSATIDTLLQFAVVEFSGILTKE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=293, Percent_Identity=24.2320819112628, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31881687, Length=293, Percent_Identity=24.2320819112628, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI6677723, Length=264, Percent_Identity=23.4848484848485, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI194306571, Length=264, Percent_Identity=23.4848484848485, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI194306567, Length=264, Percent_Identity=23.4848484848485, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=285, Percent_Identity=45.2631578947368, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1787341, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=219, Percent_Identity=29.2237442922374, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=224, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=305, Percent_Identity=24.2622950819672, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324039, Length=212, Percent_Identity=24.0566037735849, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647857, Length=215, Percent_Identity=26.9767441860465, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 49566; Mature: 49435

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPATYQVSSRKYRPQTFSEILGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARI
CCCCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FAKALNCTEPTANNEPCNRCCICKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPA
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEECCC
KSQYKIYIIDEVHMLTKEAFNSLLKTLEEPPSHVKFFLATTENYKIPGTILSRCQKMHLK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
RIPETMIVDKLESISQDISLETSREALLPIARAAQGSLRDAESLYDYVIGLFPKSLSPES
HCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHH
VTDALGLVSQDTLCNLAECIRTQKYVDALLPITTALNSGVAPTAFLHDLTVFYRDILLSK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DQENSPLAATAKLYSRECLLEIIDFLGESAKHLQQTIFEKTFLETVIIHLIRICQRPSLE
CCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TLFSQLKASAFDAPRNTSQQQEQPKPIIQPEKRYEEQSFLSSSSKSSDPQDLPKKEASTS
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCHHHHHHH
LVGSATIDTLLQFAVVEFSGILTKE
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPATYQVSSRKYRPQTFSEILGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARI
CCCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FAKALNCTEPTANNEPCNRCCICKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPA
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEECCC
KSQYKIYIIDEVHMLTKEAFNSLLKTLEEPPSHVKFFLATTENYKIPGTILSRCQKMHLK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
RIPETMIVDKLESISQDISLETSREALLPIARAAQGSLRDAESLYDYVIGLFPKSLSPES
HCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHH
VTDALGLVSQDTLCNLAECIRTQKYVDALLPITTALNSGVAPTAFLHDLTVFYRDILLSK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DQENSPLAATAKLYSRECLLEIIDFLGESAKHLQQTIFEKTFLETVIIHLIRICQRPSLE
CCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TLFSQLKASAFDAPRNTSQQQEQPKPIIQPEKRYEEQSFLSSSSKSSDPQDLPKKEASTS
HHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCHHHHHHH
LVGSATIDTLLQFAVVEFSGILTKE
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]