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The map label for this gene is hemN2 [H]

Identifier: 89898396

GI number: 89898396

Start: 692798

End: 693925

Strand: Direct

Name: hemN2 [H]

Synonym: CF0589

Alternate gene names: 89898396

Gene position: 692798-693925 (Clockwise)

Preceding gene: 89898395

Following gene: 89898397

Centisome position: 59.4

GC content: 39.54

Gene sequence:

>1128_bases
ATGCTAATGAATGGTAAAACCCCTTTAGCTCTCTACATCCATTTTCCTTTTTGCTCAAAGAAATGCCACTATTGTAACTT
TTATACGATTCCTTATAATCCGGAATCCGTGGGTTTGTATTGCAATGCAATTCTTCAAGAAGGATTGCATAAGTTGTCTA
CAATTACGGACTCGTATTTCATCGATACTGTATTTCTTGGTGGAGGAACCCCTTCATTAATTCCTCCCCATCATCTACAT
AATATCATTAAAATTCTTGCGCCTCATGCTCAAGAAATCACTCTAGAGGCTAATCCGGAAGATCTATCCGAATCCTATTT
AAGAGATCTTACCCAGACTCCTATTAATAGGATTAGCATTGGAGTACAGACCTTTCATGATCCCCTTCTAAAAGCTATAG
GAAGAATACATTCTTCATCAGCGTCTATAGACGCTGTACAGCGTTGCCACGAACACGAATATCACAATATCTCAATAGAT
CTTATTTACGGTCTCCCCACCCAGTCTTTGTCAGATTTTATTGCTGATCTTCATCAAGCTTTATCTCTCCCCATTACGCA
CCTCTCTCTTTATAACCTTACCTTGGATCCCCATACATCGTTTTATAAGCACCGACGGATTCTAGAACGTTCTATTGCTG
ACGATGACATACTTGCAGCTATGAGTCTCTCAGCTGAAGAGCTCCTCTCCTCTCATGGGTTTTCTCGTTATGAACTTGCC
TCATACGCAAAATTTCAAGCACAATCAAAGCATAATCTCTATTACTGGACAGATAAGCCATTTTTAGGATTAGGAGTCTC
TGCTTCACAATACTTCAATAAAATACGCTCGAAAAATCTCTCAAGAATCTCTCACTATCTACGCGCGCTGCGTAAAAACC
TCCCTCTTCAAGAATTCACAGAATGCCTACCTGAAGAAGAACGTATTAAAGAAGCTTTAGCTCTAAGACTACGTCTTACT
AATGGAGCCCGATGGAAAGATTTCCCTGCTCCACTCATGCAGGCTCTAGTTTCCCTTCCTCAAATTCAAGAACTCTTCGA
CCAAAACGATGAGTTTCTATTCTTAAACAAACAAGGCCGATTATTTCACGATACTATCGCTGAAGAAATCATGAATCTTT
CTTTTTAA

Upstream 100 bases:

>100_bases
CGAGAAGAGGGTGCTGTAGAAATCGACTATTCTAACGATGACGATGAAGATCCTTTTAGTGATCGGAATCGTTGGAGACG
CGGGGGAATTGTTGATCCCG

Downstream 100 bases:

>100_bases
TTTAATAAAACAAGAACAATTGTTATTAGTTTTTAAAAACAATTAATTGTTATTAAAATATGAAAGATAAAATCAATAAT
AAAGAAAACGAAGATTCAAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLMNGKTPLALYIHFPFCSKKCHYCNFYTIPYNPESVGLYCNAILQEGLHKLSTITDSYFIDTVFLGGGTPSLIPPHHLH
NIIKILAPHAQEITLEANPEDLSESYLRDLTQTPINRISIGVQTFHDPLLKAIGRIHSSSASIDAVQRCHEHEYHNISID
LIYGLPTQSLSDFIADLHQALSLPITHLSLYNLTLDPHTSFYKHRRILERSIADDDILAAMSLSAEELLSSHGFSRYELA
SYAKFQAQSKHNLYYWTDKPFLGLGVSASQYFNKIRSKNLSRISHYLRALRKNLPLQEFTECLPEEERIKEALALRLRLT
NGARWKDFPAPLMQALVSLPQIQELFDQNDEFLFLNKQGRLFHDTIAEEIMNLSF

Sequences:

>Translated_375_residues
MLMNGKTPLALYIHFPFCSKKCHYCNFYTIPYNPESVGLYCNAILQEGLHKLSTITDSYFIDTVFLGGGTPSLIPPHHLH
NIIKILAPHAQEITLEANPEDLSESYLRDLTQTPINRISIGVQTFHDPLLKAIGRIHSSSASIDAVQRCHEHEYHNISID
LIYGLPTQSLSDFIADLHQALSLPITHLSLYNLTLDPHTSFYKHRRILERSIADDDILAAMSLSAEELLSSHGFSRYELA
SYAKFQAQSKHNLYYWTDKPFLGLGVSASQYFNKIRSKNLSRISHYLRALRKNLPLQEFTECLPEEERIKEALALRLRLT
NGARWKDFPAPLMQALVSLPQIQELFDQNDEFLFLNKQGRLFHDTIAEEIMNLSF
>Mature_375_residues
MLMNGKTPLALYIHFPFCSKKCHYCNFYTIPYNPESVGLYCNAILQEGLHKLSTITDSYFIDTVFLGGGTPSLIPPHHLH
NIIKILAPHAQEITLEANPEDLSESYLRDLTQTPINRISIGVQTFHDPLLKAIGRIHSSSASIDAVQRCHEHEYHNISID
LIYGLPTQSLSDFIADLHQALSLPITHLSLYNLTLDPHTSFYKHRRILERSIADDDILAAMSLSAEELLSSHGFSRYELA
SYAKFQAQSKHNLYYWTDKPFLGLGVSASQYFNKIRSKNLSRISHYLRALRKNLPLQEFTECLPEEERIKEALALRLRLT
NGARWKDFPAPLMQALVSLPQIQELFDQNDEFLFLNKQGRLFHDTIAEEIMNLSF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=270, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=35.2941176470588, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87082341, Length=300, Percent_Identity=26.3333333333333, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42899; Mature: 42899

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMNGKTPLALYIHFPFCSKKCHYCNFYTIPYNPESVGLYCNAILQEGLHKLSTITDSYF
CCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
IDTVFLGGGTPSLIPPHHLHNIIKILAPHAQEITLEANPEDLSESYLRDLTQTPINRISI
EEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHH
GVQTFHDPLLKAIGRIHSSSASIDAVQRCHEHEYHNISIDLIYGLPTQSLSDFIADLHQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LSLPITHLSLYNLTLDPHTSFYKHRRILERSIADDDILAAMSLSAEELLSSHGFSRYELA
HCCCHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCHHHHH
SYAKFQAQSKHNLYYWTDKPFLGLGVSASQYFNKIRSKNLSRISHYLRALRKNLPLQEFT
HHHHHHHCCCCCEEEEECCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
ECLPEEERIKEALALRLRLTNGARWKDFPAPLMQALVSLPQIQELFDQNDEFLFLNKQGR
HHCCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEEEECCCCC
LFHDTIAEEIMNLSF
CHHHHHHHHHHHCCC
>Mature Secondary Structure
MLMNGKTPLALYIHFPFCSKKCHYCNFYTIPYNPESVGLYCNAILQEGLHKLSTITDSYF
CCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
IDTVFLGGGTPSLIPPHHLHNIIKILAPHAQEITLEANPEDLSESYLRDLTQTPINRISI
EEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHH
GVQTFHDPLLKAIGRIHSSSASIDAVQRCHEHEYHNISIDLIYGLPTQSLSDFIADLHQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LSLPITHLSLYNLTLDPHTSFYKHRRILERSIADDDILAAMSLSAEELLSSHGFSRYELA
HCCCHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCHHHHH
SYAKFQAQSKHNLYYWTDKPFLGLGVSASQYFNKIRSKNLSRISHYLRALRKNLPLQEFT
HHHHHHHCCCCCEEEEECCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
ECLPEEERIKEALALRLRLTNGARWKDFPAPLMQALVSLPQIQELFDQNDEFLFLNKQGR
HHCCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEEEECCCCC
LFHDTIAEEIMNLSF
CHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]