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The map label for this gene is gsa

Identifier: 89898181

GI number: 89898181

Start: 437644

End: 438957

Strand: Direct

Name: gsa

Synonym: CF0374

Alternate gene names: 89898181

Gene position: 437644-438957 (Clockwise)

Preceding gene: 89898180

Following gene: 89898182

Centisome position: 37.53

GC content: 39.88

Gene sequence:

>1314_bases
ATGCCGGTTATTGATGAGTCAACAATGACATATGCTGAAGCTTGTCGCTATTTTCCTGGAGGAGTCAATTCTCCTATACG
CGCTTGCCTTCCCGTGAGGATTGTTCCTCCTATTGTTTCTAGCGCCTGTCGTGATATTTTCATAGATAGTTTTGGAAATA
ATTTTATAGATTTCTGCGGATCTTGGGGATCGTTAATTCACGGTCATAGCCATCCGAAAATTTTAGATGCTATTTGTAAT
GCAGCATCTCATGGAACCTCTTATGGACTTACTTCCGAAAATGAAATTTCTCTAGCATCTACCCTGTTTTCCTGTTTGGA
TCTCGAGGATTATAAATTGCGATTCGTCTCTTCTGGTACAGAAGCGACAATGACTGCCGTACGTCTTGCCTGCGGGGTTA
CAAAATGCTCAATAATTGTTAAATTTTTAGGTTGTTATCATGGACACGCCGATGTCTTGTTAAAGGGGATTTCTGTAGAT
GAGAATAACCTTCAAAATGTTGCTCACATTGTGGATACCTATTTCGCCGGGCAGCCCTGCTTACCCCTAACTTTAATTTT
ACCTTACAACGATGTGATGATTTTTGAAGAAGTCATGCATCAGATAGGAGAACGTGTTGCTTGTGTGATTTTTGAACCTA
TCTGCATTAATATGGGCGTTATTCTTCCAAAACATGGATTTATTGAGAGTATTTTAGCTATGTGCCGGCGTTATTCAGCT
TTATCCATTATGGATGAAGTTGTTACTGGATTTCGCATGGGAATTCGAGGTATGCGGTCTATAATGGATGTAACTGCCGA
TATTACTGTATATGGGAAAATCCTAGGTGGGGGGATGCCTGTTGCAGCGCTTCTAGCGCATCAAAATATTATGGATCATT
TGCTTCCTTTAGGCACGGTATTTCAAGCAGGCACTCTTTCCGGGAATCCTGTTGCTATGGCTGCAGGAAAAGCCTCTATA
GAGCTTTGTTGTGAACCCAATTTTTATTCTAAATTAGAAAATCTGACAGAAGGATTCTTATCTCCTATAGAAGAAATAAT
TCGTTCTAAAGGATTTCCTGTATCTTTAGTAAGATCTGGTTCTATGTTTTCTTTTTTCTTTAGGGATACTCCTCCTGCTA
ATCTTAGTGAGGTGCAACAATGCGATCAGGAAAGATTTGGGTTATTTTATCGCCAGGCGTTTTCTCTAGGAGTGTATTTG
TCCCCCGCCTCTACTGAAGCGAGCTTTATTTCTTCTGTACACAGTAGAGAAAATCTAGCCTATACGCAAAATGTGCTTAT
TGATAGTTTGGTGAAATCTTTCGACAACGTTTAA

Upstream 100 bases:

>100_bases
AAATTAACTTGGGTTATTTATTTAATCCCTAGCGAGTCTTTTCCTAGGTTTTAAAATGGCTATGGCTCAGAATAATCCCG
GATTTAAATAGGGGATTATT

Downstream 100 bases:

>100_bases
GGTAAGGGATTTTCTCAAGGTTTTGAGGATACTGACATGGAGGCAAAAAAGCGTTCTCGTATTTTCCGCATACTTTATAC
ATTTCCTTTGGAATTAGGTA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPVIDESTMTYAEACRYFPGGVNSPIRACLPVRIVPPIVSSACRDIFIDSFGNNFIDFCGSWGSLIHGHSHPKILDAICN
AASHGTSYGLTSENEISLASTLFSCLDLEDYKLRFVSSGTEATMTAVRLACGVTKCSIIVKFLGCYHGHADVLLKGISVD
ENNLQNVAHIVDTYFAGQPCLPLTLILPYNDVMIFEEVMHQIGERVACVIFEPICINMGVILPKHGFIESILAMCRRYSA
LSIMDEVVTGFRMGIRGMRSIMDVTADITVYGKILGGGMPVAALLAHQNIMDHLLPLGTVFQAGTLSGNPVAMAAGKASI
ELCCEPNFYSKLENLTEGFLSPIEEIIRSKGFPVSLVRSGSMFSFFFRDTPPANLSEVQQCDQERFGLFYRQAFSLGVYL
SPASTEASFISSVHSRENLAYTQNVLIDSLVKSFDNV

Sequences:

>Translated_437_residues
MPVIDESTMTYAEACRYFPGGVNSPIRACLPVRIVPPIVSSACRDIFIDSFGNNFIDFCGSWGSLIHGHSHPKILDAICN
AASHGTSYGLTSENEISLASTLFSCLDLEDYKLRFVSSGTEATMTAVRLACGVTKCSIIVKFLGCYHGHADVLLKGISVD
ENNLQNVAHIVDTYFAGQPCLPLTLILPYNDVMIFEEVMHQIGERVACVIFEPICINMGVILPKHGFIESILAMCRRYSA
LSIMDEVVTGFRMGIRGMRSIMDVTADITVYGKILGGGMPVAALLAHQNIMDHLLPLGTVFQAGTLSGNPVAMAAGKASI
ELCCEPNFYSKLENLTEGFLSPIEEIIRSKGFPVSLVRSGSMFSFFFRDTPPANLSEVQQCDQERFGLFYRQAFSLGVYL
SPASTEASFISSVHSRENLAYTQNVLIDSLVKSFDNV
>Mature_436_residues
PVIDESTMTYAEACRYFPGGVNSPIRACLPVRIVPPIVSSACRDIFIDSFGNNFIDFCGSWGSLIHGHSHPKILDAICNA
ASHGTSYGLTSENEISLASTLFSCLDLEDYKLRFVSSGTEATMTAVRLACGVTKCSIIVKFLGCYHGHADVLLKGISVDE
NNLQNVAHIVDTYFAGQPCLPLTLILPYNDVMIFEEVMHQIGERVACVIFEPICINMGVILPKHGFIESILAMCRRYSAL
SIMDEVVTGFRMGIRGMRSIMDVTADITVYGKILGGGMPVAALLAHQNIMDHLLPLGTVFQAGTLSGNPVAMAAGKASIE
LCCEPNFYSKLENLTEGFLSPIEEIIRSKGFPVSLVRSGSMFSFFFRDTPPANLSEVQQCDQERFGLFYRQAFSLGVYLS
PASTEASFISSVHSRENLAYTQNVLIDSLVKSFDNV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=304, Percent_Identity=27.3026315789474, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI284507298, Length=224, Percent_Identity=29.4642857142857, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI37574042, Length=309, Percent_Identity=26.8608414239482, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24119277, Length=324, Percent_Identity=24.6913580246914, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI226442709, Length=269, Percent_Identity=27.5092936802974, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI226442705, Length=308, Percent_Identity=26.2987012987013, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786349, Length=437, Percent_Identity=38.2151029748284, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=28.1437125748503, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788044, Length=333, Percent_Identity=27.9279279279279, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789016, Length=316, Percent_Identity=27.5316455696203, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789759, Length=321, Percent_Identity=26.791277258567, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787560, Length=289, Percent_Identity=26.2975778546713, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786991, Length=295, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144271, Length=337, Percent_Identity=27.299703264095, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=194, Percent_Identity=29.3814432989691, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=353, Percent_Identity=24.3626062322946, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=22.1006564551422, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357415, Length=344, Percent_Identity=25.8720930232558, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CHLFF (Q254Z2)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_515291.1
- HSSP:   Q8DLK8
- ProteinModelPortal:   Q254Z2
- SMR:   Q254Z2
- STRING:   Q254Z2
- GeneID:   3958795
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0374
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   SFISSVH
- ProtClustDB:   PRK00615
- BioCyc:   CFEL264202:CF0374-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 47719; Mature: 47587

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIDESTMTYAEACRYFPGGVNSPIRACLPVRIVPPIVSSACRDIFIDSFGNNFIDFCG
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHC
SWGSLIHGHSHPKILDAICNAASHGTSYGLTSENEISLASTLFSCLDLEDYKLRFVSSGT
CHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCC
EATMTAVRLACGVTKCSIIVKFLGCYHGHADVLLKGISVDENNLQNVAHIVDTYFAGQPC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHHCCCCC
LPLTLILPYNDVMIFEEVMHQIGERVACVIFEPICINMGVILPKHGFIESILAMCRRYSA
CCEEEEECCCHHHHHHHHHHHHHHHEEHHEECHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LSIMDEVVTGFRMGIRGMRSIMDVTADITVYGKILGGGMPVAALLAHQNIMDHLLPLGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FQAGTLSGNPVAMAAGKASIELCCEPNFYSKLENLTEGFLSPIEEIIRSKGFPVSLVRSG
HHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SMFSFFFRDTPPANLSEVQQCDQERFGLFYRQAFSLGVYLSPASTEASFISSVHSRENLA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHH
YTQNVLIDSLVKSFDNV
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVIDESTMTYAEACRYFPGGVNSPIRACLPVRIVPPIVSSACRDIFIDSFGNNFIDFCG
CCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHC
SWGSLIHGHSHPKILDAICNAASHGTSYGLTSENEISLASTLFSCLDLEDYKLRFVSSGT
CHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCC
EATMTAVRLACGVTKCSIIVKFLGCYHGHADVLLKGISVDENNLQNVAHIVDTYFAGQPC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHHCCCCC
LPLTLILPYNDVMIFEEVMHQIGERVACVIFEPICINMGVILPKHGFIESILAMCRRYSA
CCEEEEECCCHHHHHHHHHHHHHHHEEHHEECHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LSIMDEVVTGFRMGIRGMRSIMDVTADITVYGKILGGGMPVAALLAHQNIMDHLLPLGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FQAGTLSGNPVAMAAGKASIELCCEPNFYSKLENLTEGFLSPIEEIIRSKGFPVSLVRSG
HHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SMFSFFFRDTPPANLSEVQQCDQERFGLFYRQAFSLGVYLSPASTEASFISSVHSRENLA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHH
YTQNVLIDSLVKSFDNV
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA