Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 89897870

GI number: 89897870

Start: 69002

End: 70744

Strand: Direct

Name: mutL

Synonym: CF0063

Alternate gene names: 89897870

Gene position: 69002-70744 (Clockwise)

Preceding gene: 89897865

Following gene: 89897871

Centisome position: 5.92

GC content: 43.43

Gene sequence:

>1743_bases
ATGCCTTCCAGACCCCTCATTCAACTGCTCGATACAACTACGATTAATCAGATAGCTGCAGGAGAAGTTATTGAGAACTC
CATATCTGTTGTTAAGGAGTTGGTAGAGAATGCCTTAGATGCTGGAGCTGATGAGATAGAGGTGGAAACCCTTGGAGGAG
GACAGGGCCTTATTGTTGTAAAAGACAATGGTTGTGGAATGAGTGCTGAGGATGTCACCCTGGCTCTTAAGCGTCATGCC
ACCTCAAAGATTGGGGAATTTTCTGATATTTTCTCATTATCTAGTTTTGGTTTCCGAGGGGAAGCTTTGCCCGCAATAGC
TTCGATTTCTAAAATGGAAATCCTTTCCTGTCCCAGAATAGGTGAAGGTTCTAGGACAATCATTCACGGTGGGGAAATCA
TTGCATCAGAGGCCAAGCCGCGCCAGCTAGGGACAACAATTTCCATAGATTCTTTATTTTACAATGTCCCGGTTCGTCGA
GGCTTTCAAAAGAGTCCCCAAGCAGATCGGATAGCTATGAGAAAGCTATTAGAGAATAGGATTTTATCTATAGAGGGGGT
AGGCTGGTCGTGGGTAAGTGAACGGCAACAGGAGTTTCATATACTCAAGCACCGGGGATTTGCCGAGCGTGTTGGCTTCG
TTATGGGTGAAGGATTCATGCAGGAAGCTTTAAGAGTGGATAGTGGTGAAAGACCCGTTTGTGTTAGAGGATTTCTAGGC
TCCCCGGGTTTTCATCGCCCAACACGTTCAGGACAGCGGGTTTTTATTAACGATCGTCCTGTAGATTCGGTATTTATCTC
AAAGCAAATACGGGAAGCCTATTCCATGCTATTACCTCCGCAAAGGCATCCCGTTTTCGTTTTAAAACTCTATCTTCCCC
CAGAGTGGTGTGATTTCAATGTGCATCCCCAGAAAACGGAAGTGAGAATACTTAAGGAAGAATTCGTTGGGGAATTTCTT
TCAGAGTCCATAGGAGAGGTCTTGGCACGCCCTCAAGAATCTTCTGTTTCTGAAAAAACAATATTTTCTTTGCCGGCCCT
GCGCTTTTTTGATGAACACCTTGCAGAAAGATCTTCGGTAGAGCCTTTGGAGTCTATTTCATTACCGGAATTATCAATAC
CGCCCAAGGTGCCCCTTCCTTTTCTTGATAAGGGACAGGATATCCCAACTACGGATGGGCAAATGCAGATTGATTGGGGA
GTATCTCAAGAGGTTCGGTTTTTAACTTCTTTAGGGAAAATTGTTCTTGCAGAGGACTCAGAAGGTGTTCATGCTATTTT
CACCGAAGCTGCTCGGAAACATTTATTTTATCTCGCATTGACGGAGAATCAACAATACAACTATAAAAGTCAGTCTTTTT
TGGTCCCTTTATGTTTAGAGGTTACTCCCCAAGAAGGGATTTTTCTTTCGTCTCATGTCGAGGATTTTAAACAGCTAGGG
ATAGAACTTTCTCAAATGGGTCCTTGTATATTCGCTATAGACAGTGCTCCGACATTTATAGGTGAAGAAGAACTGAAATC
ATGGATTCTTTTCTTGGCTGCAGAAAGTCACGCAAAGGTGGATAGAAAAGCTGTGGCTCTTTTGATCAAAGAGACTTTAA
CGCAGACAGTGTTTTGTAAGACTTTACGGCCTTTCGATATCTCTTGGCTTTCCTTGCTCTGGCAAATAGGTAAACCGGAA
AAAGCCTTTGACGGCACTCAAATACGTCGGTTAGTTTTAGACGAGGATTTTATTAAGGAGTAA

Upstream 100 bases:

>100_bases
CTTTTCCTTGGCTTTACGTATTATAAAAATTACGTGTCTTGACATTAGTGTTTAGGTATTTTACTTTTTGCTCTCGCAAG
ATCCTTTATTAGAATTTGCT

Downstream 100 bases:

>100_bases
ATTATGTTCCAGGATCGCATTGCAAGAGCGCAAGCAGCTCTAGCAGATTATGGTATAGACGGGTTTATTGTAGAAAGAAG
TGAGGATCTTGCGTACTTTC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MPSRPLIQLLDTTTINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVVKDNGCGMSAEDVTLALKRHA
TSKIGEFSDIFSLSSFGFRGEALPAIASISKMEILSCPRIGEGSRTIIHGGEIIASEAKPRQLGTTISIDSLFYNVPVRR
GFQKSPQADRIAMRKLLENRILSIEGVGWSWVSERQQEFHILKHRGFAERVGFVMGEGFMQEALRVDSGERPVCVRGFLG
SPGFHRPTRSGQRVFINDRPVDSVFISKQIREAYSMLLPPQRHPVFVLKLYLPPEWCDFNVHPQKTEVRILKEEFVGEFL
SESIGEVLARPQESSVSEKTIFSLPALRFFDEHLAERSSVEPLESISLPELSIPPKVPLPFLDKGQDIPTTDGQMQIDWG
VSQEVRFLTSLGKIVLAEDSEGVHAIFTEAARKHLFYLALTENQQYNYKSQSFLVPLCLEVTPQEGIFLSSHVEDFKQLG
IELSQMGPCIFAIDSAPTFIGEEELKSWILFLAAESHAKVDRKAVALLIKETLTQTVFCKTLRPFDISWLSLLWQIGKPE
KAFDGTQIRRLVLDEDFIKE

Sequences:

>Translated_580_residues
MPSRPLIQLLDTTTINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVVKDNGCGMSAEDVTLALKRHA
TSKIGEFSDIFSLSSFGFRGEALPAIASISKMEILSCPRIGEGSRTIIHGGEIIASEAKPRQLGTTISIDSLFYNVPVRR
GFQKSPQADRIAMRKLLENRILSIEGVGWSWVSERQQEFHILKHRGFAERVGFVMGEGFMQEALRVDSGERPVCVRGFLG
SPGFHRPTRSGQRVFINDRPVDSVFISKQIREAYSMLLPPQRHPVFVLKLYLPPEWCDFNVHPQKTEVRILKEEFVGEFL
SESIGEVLARPQESSVSEKTIFSLPALRFFDEHLAERSSVEPLESISLPELSIPPKVPLPFLDKGQDIPTTDGQMQIDWG
VSQEVRFLTSLGKIVLAEDSEGVHAIFTEAARKHLFYLALTENQQYNYKSQSFLVPLCLEVTPQEGIFLSSHVEDFKQLG
IELSQMGPCIFAIDSAPTFIGEEELKSWILFLAAESHAKVDRKAVALLIKETLTQTVFCKTLRPFDISWLSLLWQIGKPE
KAFDGTQIRRLVLDEDFIKE
>Mature_579_residues
PSRPLIQLLDTTTINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVVKDNGCGMSAEDVTLALKRHAT
SKIGEFSDIFSLSSFGFRGEALPAIASISKMEILSCPRIGEGSRTIIHGGEIIASEAKPRQLGTTISIDSLFYNVPVRRG
FQKSPQADRIAMRKLLENRILSIEGVGWSWVSERQQEFHILKHRGFAERVGFVMGEGFMQEALRVDSGERPVCVRGFLGS
PGFHRPTRSGQRVFINDRPVDSVFISKQIREAYSMLLPPQRHPVFVLKLYLPPEWCDFNVHPQKTEVRILKEEFVGEFLS
ESIGEVLARPQESSVSEKTIFSLPALRFFDEHLAERSSVEPLESISLPELSIPPKVPLPFLDKGQDIPTTDGQMQIDWGV
SQEVRFLTSLGKIVLAEDSEGVHAIFTEAARKHLFYLALTENQQYNYKSQSFLVPLCLEVTPQEGIFLSSHVEDFKQLGI
ELSQMGPCIFAIDSAPTFIGEEELKSWILFLAAESHAKVDRKAVALLIKETLTQTVFCKTLRPFDISWLSLLWQIGKPEK
AFDGTQIRRLVLDEDFIKE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=327, Percent_Identity=30.5810397553517, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=30.635838150289, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=30.635838150289, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI4505911, Length=338, Percent_Identity=30.4733727810651, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI189458898, Length=338, Percent_Identity=29.8816568047337, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=32.0754716981132, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=29.0969899665552, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI263191589, Length=232, Percent_Identity=24.5689655172414, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI91992162, Length=269, Percent_Identity=26.3940520446097, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI91992160, Length=269, Percent_Identity=26.3940520446097, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790612, Length=373, Percent_Identity=34.0482573726542, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=30.625, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17562796, Length=146, Percent_Identity=37.6712328767123, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=25.8064516129032, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324247, Length=360, Percent_Identity=24.4444444444444, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=29.3577981651376, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=27.887323943662, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLFF (Q256F3)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_514980.1
- ProteinModelPortal:   Q256F3
- STRING:   Q256F3
- GeneID:   3958928
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0063
- eggNOG:   COG0323
- HOGENOM:   HBG414122
- OMA:   RRGFQKS
- ProtClustDB:   PRK00095
- BioCyc:   CFEL264202:CF0063-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64798; Mature: 64667

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRPLIQLLDTTTINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVV
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
KDNGCGMSAEDVTLALKRHATSKIGEFSDIFSLSSFGFRGEALPAIASISKMEILSCPRI
ECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GEGSRTIIHGGEIIASEAKPRQLGTTISIDSLFYNVPVRRGFQKSPQADRIAMRKLLENR
CCCCEEEEECCEEEECCCCCCCCCCEEEEHHHEEECCHHCCCCCCCCHHHHHHHHHHHHC
ILSIEGVGWSWVSERQQEFHILKHRGFAERVGFVMGEGFMQEALRVDSGERPVCVRGFLG
CEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCC
SPGFHRPTRSGQRVFINDRPVDSVFISKQIREAYSMLLPPQRHPVFVLKLYLPPEWCDFN
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
VHPQKTEVRILKEEFVGEFLSESIGEVLARPQESSVSEKTIFSLPALRFFDEHLAERSSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
EPLESISLPELSIPPKVPLPFLDKGQDIPTTDGQMQIDWGVSQEVRFLTSLGKIVLAEDS
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEECC
EGVHAIFTEAARKHLFYLALTENQQYNYKSQSFLVPLCLEVTPQEGIFLSSHVEDFKQLG
CCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHC
IELSQMGPCIFAIDSAPTFIGEEELKSWILFLAAESHAKVDRKAVALLIKETLTQTVFCK
CCHHHCCCEEEEECCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TLRPFDISWLSLLWQIGKPEKAFDGTQIRRLVLDEDFIKE
HCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHCC
>Mature Secondary Structure 
PSRPLIQLLDTTTINQIAAGEVIENSISVVKELVENALDAGADEIEVETLGGGQGLIVV
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
KDNGCGMSAEDVTLALKRHATSKIGEFSDIFSLSSFGFRGEALPAIASISKMEILSCPRI
ECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GEGSRTIIHGGEIIASEAKPRQLGTTISIDSLFYNVPVRRGFQKSPQADRIAMRKLLENR
CCCCEEEEECCEEEECCCCCCCCCCEEEEHHHEEECCHHCCCCCCCCHHHHHHHHHHHHC
ILSIEGVGWSWVSERQQEFHILKHRGFAERVGFVMGEGFMQEALRVDSGERPVCVRGFLG
CEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCC
SPGFHRPTRSGQRVFINDRPVDSVFISKQIREAYSMLLPPQRHPVFVLKLYLPPEWCDFN
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
VHPQKTEVRILKEEFVGEFLSESIGEVLARPQESSVSEKTIFSLPALRFFDEHLAERSSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
EPLESISLPELSIPPKVPLPFLDKGQDIPTTDGQMQIDWGVSQEVRFLTSLGKIVLAEDS
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEECC
EGVHAIFTEAARKHLFYLALTENQQYNYKSQSFLVPLCLEVTPQEGIFLSSHVEDFKQLG
CCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHC
IELSQMGPCIFAIDSAPTFIGEEELKSWILFLAAESHAKVDRKAVALLIKETLTQTVFCK
CCHHHCCCEEEEECCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TLRPFDISWLSLLWQIGKPEKAFDGTQIRRLVLDEDFIKE
HCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA