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The map label for this gene is nuoM [H]

Identifier: 89257078

GI number: 89257078

Start: 1751621

End: 1753210

Strand: Reverse

Name: nuoM [H]

Synonym: FTL_1818

Alternate gene names: 89257078

Gene position: 1753210-1751621 (Counterclockwise)

Preceding gene: 89257079

Following gene: 89257077

Centisome position: 92.47

GC content: 36.04

Gene sequence:

>1590_bases
ATGAATTTAGGTAATTACTTATTAAGTTTAATAATCTGGCTCCCAATAGTTGGTGGTTTTGTTGTTTTGGCGACAAGAAC
CAAAGAGTTGCATGGCGATGTAGCACGTTGGGTAGCATTAGTCTTTAGTTGTTTAACTCTAGCTTTATGTATTCCGTTAG
TTACATCTTTTGATTATAGTAGTTCAGCAATGCAGTTCCAAGAATCAGTAAAATGGTTTAAGGTTTTTGGCATGCATGAT
ATTTACTATAGTTTGGGAGTAGATGGATTTTCTGTATTATTTATAGTTTTGACATCTTTTGCTACATTAGTAATAGTTTT
AGCTGCTTGGATATCTATCAAAACTAAAGTTAGACAATACATGGCGATATTTTTGATTACATGTGGTTTGACTAATGGCG
TTTTCTGTGCGACTGATTCGATACTTTATTATGTTTTCTGGGAGGCGCTATTAATTCCAACTTGCCTTGGTATTGGTATT
TGGGGTGGTAAGCACAAAGCGTATGCTGCAGTTAAATACTTTATGTATACATTCTTTGGTTCGGTATTTTTACTAGCAGC
TATTTTGTATATTCAAACACGAGTTGCTGCTTCACCGACACACTTTTTGGTAAATCAAGATACTTATTCTATTCAGAATT
TTATCGCTTGGGCAACTCAGTCACAAGGCTTTATAGATTCTGTTAAATTTACTCTAACAGCACAATGGTTAGTTTTTGGG
GCATTTTTCTTAGCATTTGCTGTTAAGATTCCGATGTGGCCATTTCACTCATGGTTACCAGATGCTCACTCAGAGGCGCC
TGCTGGTGGTTCTGTCATCCTTGCAGCCCTTATGCTTAAGCTAGGTGCTTATGGTTTCTTAAGATTTGCTATTCCAATGC
TGCCAGAGGTAACAGCATCTCTCGAGTATGTTTTGATTATAATGTCTTTGATAGCTATAGTTTATGTTGGGGTTGTTGCT
GTTGCACAAACTGATGTTAAAAGACTAATTGCATATTCATCAATTTCTCATATGGGTCTAGTTACTCTTGGTTTATTCTC
AATATTTATATTGAAAAATGCTGATCCAGTATTAGGGACAACTCATGCGCAATTAGCTTTACAAGGCGCAGTGTTTCAGA
TGATTGCTCATGCTTTTTCATCTGGTGGTATGTTTATTGGTATTGGTTATTTATATTTGAGAATGCATACTAGAGAAATA
TCAGATTTCTCTGGTGTAGCTAAAACTATGCCAATATTTGCAACATTCTTTTTGCTTTTCTGTATGGCGAATGTTGGTTT
ACCTGGCACAAGTGGATTTGTTGGTGAGTTTATGATCTTACTGGCAGTATTTCAATACTCTCCATTAATAGCATTAATTG
CAGGATTAACTCTTGTGATCGCTCCAATTTATACTCTTTGGATGTATAAGCGAGTTTTCTTCGGTGAGGTTGTATCTACA
CAGGTAGCAAGCTTGACTGATTTAAATAGGATGGAGCTATTTGTATTTATATTATTAGCGGTACCGATTTTATTGTTTGG
TTTCTATCCAGAGCCAATTTTGCAGCTATCAGCAGCAGCATCGGCACATATTGTTGGTCTATCTCTATAA

Upstream 100 bases:

>100_bases
GGATATTTGTTTGACTATGCATTTGTGATGATGGTTGGTGTATTATTGTTTATGATTTTGCTAATTTCTGTTTAGGCAAG
TTAGAGGATAAATTTGTATT

Downstream 100 bases:

>100_bases
GGTGGTGTTTTGATTATGAGTTTATCAATCCTTTATATTTTGCCAGAAATACTACTAGCACTAGGTGTCATAGTTGTAAT
GTTTTCTGGACTTTTTCTAC

Product: NADH dehydrogenase I, M subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MNLGNYLLSLIIWLPIVGGFVVLATRTKELHGDVARWVALVFSCLTLALCIPLVTSFDYSSSAMQFQESVKWFKVFGMHD
IYYSLGVDGFSVLFIVLTSFATLVIVLAAWISIKTKVRQYMAIFLITCGLTNGVFCATDSILYYVFWEALLIPTCLGIGI
WGGKHKAYAAVKYFMYTFFGSVFLLAAILYIQTRVAASPTHFLVNQDTYSIQNFIAWATQSQGFIDSVKFTLTAQWLVFG
AFFLAFAVKIPMWPFHSWLPDAHSEAPAGGSVILAALMLKLGAYGFLRFAIPMLPEVTASLEYVLIIMSLIAIVYVGVVA
VAQTDVKRLIAYSSISHMGLVTLGLFSIFILKNADPVLGTTHAQLALQGAVFQMIAHAFSSGGMFIGIGYLYLRMHTREI
SDFSGVAKTMPIFATFFLLFCMANVGLPGTSGFVGEFMILLAVFQYSPLIALIAGLTLVIAPIYTLWMYKRVFFGEVVST
QVASLTDLNRMELFVFILLAVPILLFGFYPEPILQLSAAASAHIVGLSL

Sequences:

>Translated_529_residues
MNLGNYLLSLIIWLPIVGGFVVLATRTKELHGDVARWVALVFSCLTLALCIPLVTSFDYSSSAMQFQESVKWFKVFGMHD
IYYSLGVDGFSVLFIVLTSFATLVIVLAAWISIKTKVRQYMAIFLITCGLTNGVFCATDSILYYVFWEALLIPTCLGIGI
WGGKHKAYAAVKYFMYTFFGSVFLLAAILYIQTRVAASPTHFLVNQDTYSIQNFIAWATQSQGFIDSVKFTLTAQWLVFG
AFFLAFAVKIPMWPFHSWLPDAHSEAPAGGSVILAALMLKLGAYGFLRFAIPMLPEVTASLEYVLIIMSLIAIVYVGVVA
VAQTDVKRLIAYSSISHMGLVTLGLFSIFILKNADPVLGTTHAQLALQGAVFQMIAHAFSSGGMFIGIGYLYLRMHTREI
SDFSGVAKTMPIFATFFLLFCMANVGLPGTSGFVGEFMILLAVFQYSPLIALIAGLTLVIAPIYTLWMYKRVFFGEVVST
QVASLTDLNRMELFVFILLAVPILLFGFYPEPILQLSAAASAHIVGLSL
>Mature_529_residues
MNLGNYLLSLIIWLPIVGGFVVLATRTKELHGDVARWVALVFSCLTLALCIPLVTSFDYSSSAMQFQESVKWFKVFGMHD
IYYSLGVDGFSVLFIVLTSFATLVIVLAAWISIKTKVRQYMAIFLITCGLTNGVFCATDSILYYVFWEALLIPTCLGIGI
WGGKHKAYAAVKYFMYTFFGSVFLLAAILYIQTRVAASPTHFLVNQDTYSIQNFIAWATQSQGFIDSVKFTLTAQWLVFG
AFFLAFAVKIPMWPFHSWLPDAHSEAPAGGSVILAALMLKLGAYGFLRFAIPMLPEVTASLEYVLIIMSLIAIVYVGVVA
VAQTDVKRLIAYSSISHMGLVTLGLFSIFILKNADPVLGTTHAQLALQGAVFQMIAHAFSSGGMFIGIGYLYLRMHTREI
SDFSGVAKTMPIFATFFLLFCMANVGLPGTSGFVGEFMILLAVFQYSPLIALIAGLTLVIAPIYTLWMYKRVFFGEVVST
QVASLTDLNRMELFVFILLAVPILLFGFYPEPILQLSAAASAHIVGLSL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=387, Percent_Identity=32.5581395348837, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI251831117, Length=416, Percent_Identity=22.8365384615385, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788613, Length=531, Percent_Identity=38.0414312617702, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788827, Length=272, Percent_Identity=29.7794117647059, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788831, Length=391, Percent_Identity=25.5754475703325, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788829, Length=512, Percent_Identity=25.78125, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788614, Length=492, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693160, Length=376, Percent_Identity=23.936170212766, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI2367154, Length=400, Percent_Identity=24, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 58231; Mature: 58231

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHEEEECC
>Mature Secondary Structure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HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]