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The map label for this gene is hemE [H]

Identifier: 89257075

GI number: 89257075

Start: 1746337

End: 1747371

Strand: Reverse

Name: hemE [H]

Synonym: FTL_1812

Alternate gene names: 89257075

Gene position: 1747371-1746337 (Counterclockwise)

Preceding gene: 89257077

Following gene: 89257074

Centisome position: 92.16

GC content: 35.75

Gene sequence:

>1035_bases
ATGAGAAAATTATTTTTGGATGCATTTGGCGAAAAGAAATTAGATAAGCCCCCAGTTTGGATAATGCGTCAAGCTGGTAG
ATATCTACCAGAGTATCGTGCAGTTAGGGTAAAGTTTGATAATTTTATGGATATGTGCCGCAATGCTGATGCTTGTTGTG
AAGTTGCGCTTCATCCACTTCAGAGGTATGATCTTGACGCAGCAATTGTTTTTTCAGATATTCTGACAATTCCAGAAGCT
ATGGGGATGGACCTAAAATTTATAAAAGGTGCGGGGCCAGTCTTTTCTGAGCCGATACAATCGCAAAAAGATTTAGATAA
GCTAAAATCTATTGAAGATAGTATTGGTTCGCTAGATTATGTTTATAATGCTGTCAAGACTACTAGTTCAGCAATAAATG
TACCTTTAATAGGCTTTACTGGAAGTCCTTGGACTTTAGCGGCATATATGATTGAAGGTTCAGGATCTAAGCAGTTCAAT
AAATTGCGTAAGATGATGTATGCAAATCCTCAGTTGATGCATAGCTTATTACAACGCCTTGCAGATATAACAATTATCTA
TTTGCTTGAGCAGGTTAAGGCTGGCGCGAGTTCTGTGATGATATTTGATACTTGGGGAGGTATACTACCTTTAGAACATT
ATAAAAATTTCTCTCTTAAATATATGGAGTATATTGCTAAGAATGTAAAGCAAAAAATTAATATACCTATAGTTTTCTTT
ACTAAGGGTGGATCAAACTTTTTTGAAGAGATAAAAGATAAATCCTGTGATGGAGTAGGAGTTGATTGGAGTGTTACATT
AAAACAGGCACGACACAGAATAGGGGTTGGGAAAGTTCTGCAAGGGAACTTTGATCCCGCATTTTTATATGGGTCTAAGC
AAAGTATTAGGGAGACTGTTAGAGCCAATATTGAATTTATCCAGTCAGATAAGCTAAATAATTATATTGTCAACTTAGGT
CATGGAATTTATCCTGATATAGATCCTGATAGTGTTAGAGTTATGATAGATGCGATTAGAGAATTTAGTGCTTAA

Upstream 100 bases:

>100_bases
TCCAAGAAGCTATTAGTTATAGAAAAATGGATAAGTTTATCAAGTAAGTGATATAAATTTAGTGGTTAATTATTATTTAT
TAATTTAATGAAGGTAATAT

Downstream 100 bases:

>100_bases
TTATTTAGAAATGAGTGTCACATCAAAAAGTCTTGACATCACTAAAAATGTTGATATCATATATTGCAATAGACGCGGGG
TGGAGCAGCTTGGTAGCTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRVKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGAGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA

Sequences:

>Translated_344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRVKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGAGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA
>Mature_344_residues
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRVKFDNFMDMCRNADACCEVALHPLQRYDLDAAIVFSDILTIPEA
MGMDLKFIKGAGPVFSEPIQSQKDLDKLKSIEDSIGSLDYVYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFN
KLRKMMYANPQLMHSLLQRLADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETVRANIEFIQSDKLNNYIVNLG
HGIYPDIDPDSVRVMIDAIREFSA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=41.7867435158501, Blast_Score=299, Evalue=2e-81,
Organism=Escherichia coli, GI2367337, Length=344, Percent_Identity=46.8023255813954, Blast_Score=336, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6320252, Length=347, Percent_Identity=39.7694524495677, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI19921920, Length=336, Percent_Identity=36.9047619047619, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI221330099, Length=336, Percent_Identity=36.9047619047619, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38874; Mature: 38874

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRVKFDNFMDMCRNADACCEVALHPL
CCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHEEEEEHHHHHHHHCCHHHHHHHHHHHH
QRYDLDAAIVFSDILTIPEAMGMDLKFIKGAGPVFSEPIQSQKDLDKLKSIEDSIGSLDY
HHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
VYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFNKLRKMMYANPQLMHSLLQRL
HHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
ADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETV
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHH
RANIEFIQSDKLNNYIVNLGHGIYPDIDPDSVRVMIDAIREFSA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLFLDAFGEKKLDKPPVWIMRQAGRYLPEYRAVRVKFDNFMDMCRNADACCEVALHPL
CCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHEEEEEHHHHHHHHCCHHHHHHHHHHHH
QRYDLDAAIVFSDILTIPEAMGMDLKFIKGAGPVFSEPIQSQKDLDKLKSIEDSIGSLDY
HHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
VYNAVKTTSSAINVPLIGFTGSPWTLAAYMIEGSGSKQFNKLRKMMYANPQLMHSLLQRL
HHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
ADITIIYLLEQVKAGASSVMIFDTWGGILPLEHYKNFSLKYMEYIAKNVKQKINIPIVFF
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
TKGGSNFFEEIKDKSCDGVGVDWSVTLKQARHRIGVGKVLQGNFDPAFLYGSKQSIRETV
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHH
RANIEFIQSDKLNNYIVNLGHGIYPDIDPDSVRVMIDAIREFSA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA