Click here to switch to the map view.

The map label for this gene is bcr [H]

Identifier: 89256901

GI number: 89256901

Start: 1554588

End: 1555781

Strand: Direct

Name: bcr [H]

Synonym: FTL_1624

Alternate gene names: 89256901

Gene position: 1554588-1555781 (Clockwise)

Preceding gene: 89256896

Following gene: 89256902

Centisome position: 81.99

GC content: 31.57

Gene sequence:

>1194_bases
ATGATTAAACAAGATAGTAAGCTTTTTATTCTTACACTTGGGCTTTTGGCAATGCTACCACCATTTGCAGTCAATACTTA
TGCTCCAGCTATCCCAAATATTGCTGAGCATTTTGGAATTCATCCAAACGATGTAATTTTCACCTTTACAACATATTTTA
TTGGCTTCTCTATAGGGATGCTTTTTTGGAGATCTTTTTCAGATAAGTTCGGTAGAAAGCTTAGTCTAATTTTAGGTATG
TTTTTATATGCTGCGAGTACTTTATTATGTGCCCATAGCCAAAGTTTTTCACAACTTGCTGTTTTTAGATTGATACAAGA
TTTAACAGACTCCTCAGGTACAGTGATTGCTTTAGCAATTGCTAGAGACTGCTATAGTGGTAAAAAACTAACAAATATCA
TCTCAACTCTAGCAATAATAATGTTGATTTCACCGATTATTTCTCCTATGATTGGAACCAGACTAATTGTATCAACACAA
AGTTGGAAAAGCTCTTTTTACTTTTTATTTGGATTTGGCATAGTACTTGTAATTCTTTGTAGTAAACTCCCAGAAACACA
TGCAAAAGAACAAAGAGAAAAATCTATCAAGAAATTATTTATAGCCTACTTCTACCATTTGCGAAATTTACCTTTTACTA
TATACACAATTTGTTCGGGTTTATTATTTGCTGCCTTTTTTAGTTATATTGGCGCTTCTTCTATAATTTATCTAAACGTC
TACGATACTGGCTATACTCTTTATATGTTATATTTTGCTTTAACGACTATCGGAGTTATCTTGGCAAATCTTACATTAAA
GCAATTAAGTGAATCAGTTGAACTTGAAGTATTTACACGTCTTGGACTTAGTATATCACTTCTTAGTGTGTTTGTTATGA
TTATTTATAGTCATACGCAATTCAAGCATGGTTATATTTTCATGTTATTAATGCTTATTACTTGTTATGGCTTAAGTCTA
AGTTCGACTTCACTATTAAGTCAGTCATTGCAGCTAATATCTAATCATTTTGGTGCAGCTACAGCTGTAAATAACTTTTT
CAAATTTTCACTTGCTGGCTTTGCCAACTTTGTAATGAGCTTTTCAGTTGGCTCTATGCTTGTATCAAACTTACCTTTAC
AGCAATTGACTATTATCTTAATCACAATAATACTTTTGTGTATTACTAAATACTATAAAAAAGCTAAGTCTTAA

Upstream 100 bases:

>100_bases
TTATATATTACAAAAAATTATACTTCTAATGTATATTTACAAAAAAACTACATAGTACTCTTAACAAAAATTGAATCAAA
ACTTTTAAGTAATTTTCATC

Downstream 100 bases:

>100_bases
CCATAACAACTGTAAGCGAAAGGTTTAAAATGACAAAACAAGAACTAAGAAACTACTATCAGCTAGCTTTTATTAATGGA
GTCAATGATGCGATTTCAGT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWRSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQDLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLSISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS

Sequences:

>Translated_397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWRSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQDLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLSISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
>Mature_397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWRSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQDLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLSISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=260, Percent_Identity=30, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI48994889, Length=402, Percent_Identity=23.134328358209, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790146, Length=198, Percent_Identity=25.7575757575758, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082312, Length=225, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325414, Length=152, Percent_Identity=26.9736842105263, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321577, Length=152, Percent_Identity=26.9736842105263, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=199, Percent_Identity=24.6231155778894, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44367; Mature: 44367

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGM
CCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
LFWRSFSDKFGRKLSLILGMFLYAASTLLCAHSQSFSQLAVFRLIQDLTDSSGTVIALAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
ARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQSWKSSFYFLFGFGIVLVILC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
SKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLSISLLSVFVMIIYSHTQ
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
FKHGYIFMLLMLITCYGLSLSSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMS
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGM
CCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
LFWRSFSDKFGRKLSLILGMFLYAASTLLCAHSQSFSQLAVFRLIQDLTDSSGTVIALAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
ARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQSWKSSFYFLFGFGIVLVILC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
SKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLSISLLSVFVMIIYSHTQ
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
FKHGYIFMLLMLITCYGLSLSSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMS
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]