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The map label for this gene is hsrA [H]

Identifier: 89256755

GI number: 89256755

Start: 1390974

End: 1391549

Strand: Direct

Name: hsrA [H]

Synonym: FTL_1466

Alternate gene names: 89256755

Gene position: 1390974-1391549 (Clockwise)

Preceding gene: 89256754

Following gene: 89256756

Centisome position: 73.36

GC content: 33.85

Gene sequence:

>576_bases
ATGTTCTCATCTATAGCATATGGACTATCGACCAATCTTATTAGTCTAGTTGTCTTTAGAGCTATTCAAGGAGCTTTTGG
AGCTTTTACCGCACCTGTTGCCCGTTTAGCAATGGTTAGAATCTACAAAAATGATGTACTCACAGCAATGTCGATAGTTG
CTGTAATAGCTGCGTTAGGACCAATGTTTGGACCTTTGTTTGGAGGAGCGATTACTACTCACATTGGCTGGAGAATGATT
TTTTTCATTAATGTCCCAATTGGTATGATAGCTATAACTTTAATTTATCTACATCTACCGAATATAACATCTCTTACGTT
AAGAAAATTTGATTTGAAAGGTTTTATTATCATTGACACATCTATCGCACTAATATTATTTTTTATAGACTTATTGATAG
ATACACACCTTGCTCACATAAAATGGTTGTTACTAATCTCTGCAGTTATCCTCTTTGGTATATATATACGCCATGCTCAA
CGTCTCAAAGATGATGCTGTTATCAACTTAACTATTTTTAAAGACCGTTGTTTTAGATATTTCACCATAATTAGGTTCTG
TGCACAAAAAACTTAA

Upstream 100 bases:

>100_bases
ACTGTATATTTGCTTGCTTTGGGATTATTTATCCCAGCATCTGGGGATATCAGATAAAATTGGCAGTAAAAATCTATTAC
TACTCTCAATCACTAGCTTT

Downstream 100 bases:

>100_bases
ATTATATTGAAAATAGCTAAACTGCTGTTATTTAAGATTTGAAAAGCAATAAATATCAATGGTTTAGCAAATGAATTATC
ATATAAAAGAAGTATTCTGG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MFSSIAYGLSTNLISLVVFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMFGPLFGGAITTHIGWRMI
FFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIDTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHAQ
RLKDDAVINLTIFKDRCFRYFTIIRFCAQKT

Sequences:

>Translated_191_residues
MFSSIAYGLSTNLISLVVFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMFGPLFGGAITTHIGWRMI
FFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIDTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHAQ
RLKDDAVINLTIFKDRCFRYFTIIRFCAQKT
>Mature_191_residues
MFSSIAYGLSTNLISLVVFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMFGPLFGGAITTHIGWRMI
FFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIDTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHAQ
RLKDDAVINLTIFKDRCFRYFTIIRFCAQKT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=179, Percent_Identity=38.5474860335196, Blast_Score=116, Evalue=8e-28,
Organism=Escherichia coli, GI1788392, Length=172, Percent_Identity=33.7209302325581, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788710, Length=183, Percent_Identity=26.775956284153, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 21412; Mature: 21412

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSIAYGLSTNLISLVVFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMFGPLFGGAITTHIGWRMIFFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIDT
HHHHHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHCCCCCHHHHEEECCCEEEEEHH
SIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHAQRLKDDAVINLTIFKDRCFRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
FTIIRFCAQKT
HHHHHHHHCCC
>Mature Secondary Structure
MFSSIAYGLSTNLISLVVFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMFGPLFGGAITTHIGWRMIFFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIDT
HHHHHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHCCCCCHHHHEEECCCEEEEEHH
SIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHAQRLKDDAVINLTIFKDRCFRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
FTIIRFCAQKT
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]