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The map label for this gene is rnd [H]

Identifier: 89256742

GI number: 89256742

Start: 1375783

End: 1376877

Strand: Direct

Name: rnd [H]

Synonym: FTL_1449

Alternate gene names: 89256742

Gene position: 1375783-1376877 (Clockwise)

Preceding gene: 89256739

Following gene: 89256743

Centisome position: 72.56

GC content: 28.22

Gene sequence:

>1095_bases
ATGATAATTAATACAAATAAGCAATTAAATAATGTGATAGAAATTCTTAAAAACACTTCACAAATAGCTGTAGATACTGA
ATTCTACTGGATGCGTACATACTATCCTGAGCTTTGCCTAGTACAGCTAGCAACTGAAAATGAGATATTTCTGATAGATA
CACTAAAAGATTTAGAGTTTAAGAAGTTAAAAGAGATTTTTGAAGATAAGGATATTCTAAAAATAATCCACTCGGCAACT
AATGATATTCCTATTATTAAAAGGTTCTTTAACTGCGAAGTAAATAATATTTTTGATACACAACTTGCAGCCACTTTTCT
CGGTTTTCAAACACAATCATCTCTAAAAACTCTACTGAAAGAAATTTTAGATATTGAAATAGAAAAAGAATCTCAATTTT
CAGATTGGCGCAATAGACCCCTAACACAAAATCAACTTAACTATGCTATCAAAGATGTTGAATATCTCATACAACTAAAA
GAGTATTTACAGCAACAACTAGCTAAAAGTGAATATCAAGATTTCTTTGAGCAAGAACTAATTGAGGTACAAAAAACTCA
ATTTAACTCTATTGAAAATATTCATGCCAAGATAGGCAATATTCAAAAGTTTGATGAAAAGACTCAAAGAAATGCTATTT
TAATAGCTCAATGGCGTGAAACTATTGCTCAAGAAAAAAATATTCCTGTAAGATTTATTTTTAATAATAAAATCTTATAT
ACGATAGCTCATATAAATCCTAAATCTCTTAACTCTTTTGAACACAGTGAGCTAAAAAGTTTAAAACCTTGGATTAAAAA
AGGCGTCGTTACAGCACTTAACTCATCTAAAAGCTTAGATCAAGTGACTTTAGAACAAAAAAGTGGCAGTAAATTGTCTA
CAGAATTAAATGATAAGATAATTGATTTTTTTGACACATATACTAAGCAACTTAAGTTTGATTCTAGTATAATCGCTTCA
AGAAAAGATATTCGTTCTCTCGCATATAATCTAAATATTGATACTAACTACAAAAACAATAAACTACTAAATGGTTGGCG
ATATGAAATAGTTGGTAAAAAATTAAAAGAGTATATACTTAGTAACACGAAATAA

Upstream 100 bases:

>100_bases
ATTAAACACTGAGTTTATGAAAAATGTTAACATATATAAACTTTTATACTAATTAAATACATAAGTTTAAATTTCTCTAA
GTATTTTAACTAAAAAAACG

Downstream 100 bases:

>100_bases
AATTATTAATAACCATATTCTAATATCTATGAAACTTATAACTAGAAATTCTAAATTATTCCCTATAATTTTGGCATTAT
TTGCTGCGTTACCACCTCTA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MIINTNKQLNNVIEILKNTSQIAVDTEFYWMRTYYPELCLVQLATENEIFLIDTLKDLEFKKLKEIFEDKDILKIIHSAT
NDIPIIKRFFNCEVNNIFDTQLAATFLGFQTQSSLKTLLKEILDIEIEKESQFSDWRNRPLTQNQLNYAIKDVEYLIQLK
EYLQQQLAKSEYQDFFEQELIEVQKTQFNSIENIHAKIGNIQKFDEKTQRNAILIAQWRETIAQEKNIPVRFIFNNKILY
TIAHINPKSLNSFEHSELKSLKPWIKKGVVTALNSSKSLDQVTLEQKSGSKLSTELNDKIIDFFDTYTKQLKFDSSIIAS
RKDIRSLAYNLNIDTNYKNNKLLNGWRYEIVGKKLKEYILSNTK

Sequences:

>Translated_364_residues
MIINTNKQLNNVIEILKNTSQIAVDTEFYWMRTYYPELCLVQLATENEIFLIDTLKDLEFKKLKEIFEDKDILKIIHSAT
NDIPIIKRFFNCEVNNIFDTQLAATFLGFQTQSSLKTLLKEILDIEIEKESQFSDWRNRPLTQNQLNYAIKDVEYLIQLK
EYLQQQLAKSEYQDFFEQELIEVQKTQFNSIENIHAKIGNIQKFDEKTQRNAILIAQWRETIAQEKNIPVRFIFNNKILY
TIAHINPKSLNSFEHSELKSLKPWIKKGVVTALNSSKSLDQVTLEQKSGSKLSTELNDKIIDFFDTYTKQLKFDSSIIAS
RKDIRSLAYNLNIDTNYKNNKLLNGWRYEIVGKKLKEYILSNTK
>Mature_364_residues
MIINTNKQLNNVIEILKNTSQIAVDTEFYWMRTYYPELCLVQLATENEIFLIDTLKDLEFKKLKEIFEDKDILKIIHSAT
NDIPIIKRFFNCEVNNIFDTQLAATFLGFQTQSSLKTLLKEILDIEIEKESQFSDWRNRPLTQNQLNYAIKDVEYLIQLK
EYLQQQLAKSEYQDFFEQELIEVQKTQFNSIENIHAKIGNIQKFDEKTQRNAILIAQWRETIAQEKNIPVRFIFNNKILY
TIAHINPKSLNSFEHSELKSLKPWIKKGVVTALNSSKSLDQVTLEQKSGSKLSTELNDKIIDFFDTYTKQLKFDSSIIAS
RKDIRSLAYNLNIDTNYKNNKLLNGWRYEIVGKKLKEYILSNTK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=153, Percent_Identity=36.6013071895425, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4505917, Length=153, Percent_Identity=36.6013071895425, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1788105, Length=369, Percent_Identity=26.5582655826558, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17531757, Length=258, Percent_Identity=27.1317829457364, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324574, Length=263, Percent_Identity=28.8973384030418, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078302, Length=269, Percent_Identity=30.8550185873606, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42825; Mature: 42825

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIINTNKQLNNVIEILKNTSQIAVDTEFYWMRTYYPELCLVQLATENEIFLIDTLKDLEF
CEECCCHHHHHHHHHHHCCCCEEEECCEEEHHHHCCHHEEEEEECCCCEEEEECHHCCHH
KKLKEIFEDKDILKIIHSATNDIPIIKRFFNCEVNNIFDTQLAATFLGFQTQSSLKTLLK
HHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
EILDIEIEKESQFSDWRNRPLTQNQLNYAIKDVEYLIQLKEYLQQQLAKSEYQDFFEQEL
HHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVQKTQFNSIENIHAKIGNIQKFDEKTQRNAILIAQWRETIAQEKNIPVRFIFNNKILY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEHHHHHHHHHCCCCCEEEEECCEEEE
TIAHINPKSLNSFEHSELKSLKPWIKKGVVTALNSSKSLDQVTLEQKSGSKLSTELNDKI
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHH
IDFFDTYTKQLKFDSSIIASRKDIRSLAYNLNIDTNYKNNKLLNGWRYEIVGKKLKEYIL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SNTK
CCCC
>Mature Secondary Structure
MIINTNKQLNNVIEILKNTSQIAVDTEFYWMRTYYPELCLVQLATENEIFLIDTLKDLEF
CEECCCHHHHHHHHHHHCCCCEEEECCEEEHHHHCCHHEEEEEECCCCEEEEECHHCCHH
KKLKEIFEDKDILKIIHSATNDIPIIKRFFNCEVNNIFDTQLAATFLGFQTQSSLKTLLK
HHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
EILDIEIEKESQFSDWRNRPLTQNQLNYAIKDVEYLIQLKEYLQQQLAKSEYQDFFEQEL
HHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVQKTQFNSIENIHAKIGNIQKFDEKTQRNAILIAQWRETIAQEKNIPVRFIFNNKILY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEHHHHHHHHHCCCCCEEEEECCEEEE
TIAHINPKSLNSFEHSELKSLKPWIKKGVVTALNSSKSLDQVTLEQKSGSKLSTELNDKI
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHH
IDFFDTYTKQLKFDSSIIASRKDIRSLAYNLNIDTNYKNNKLLNGWRYEIVGKKLKEYIL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SNTK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]