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The map label for this gene is thrC [H]

Identifier: 89255905

GI number: 89255905

Start: 482791

End: 484083

Strand: Direct

Name: thrC [H]

Synonym: FTL_0498

Alternate gene names: 89255905

Gene position: 482791-484083 (Clockwise)

Preceding gene: 89255903

Following gene: 89255906

Centisome position: 25.46

GC content: 34.49

Gene sequence:

>1293_bases
ATGAATTTTATTAGTACTAGAGATAAAAATATTAAAGTTTCACTAAGTGAAGCGATGCAGTCTGGATTAGCTCTTGATGG
AGGATTATTTGTCCCAGAGAGATTTCCTACAGTTAATTGGCAGAGTTTTGCTAAAGATATCAGTTACGCGAAGTTTGCTG
CTAATACTCTAAGAGAATTCTTTAAAGGAGATCAGCTAGAAGACTCTTTAGATAAAATTTGTAATAATGCTTTTACTTTT
GAGGCTCCTGTAAGAAGATTAGATAAAACCACATCAGTTTTAGAGCTTTTTCATGGTCCAACTTTATCTTTTAAAGATTT
CGGTGCGAGATTTTTAGCAAACTGTTTAAGCTCTATCGATAGTGAGAAGCCATTTACTATTTTAGTGGCAACTTCTGGAG
ATACAGGTTCAGCAGTAGCTGCAGCTTTTCATGGTAAGAGCAATATCCGTGTTATAGTGATGTTTCCTAAAGGTAAAATC
TCTAAAAGACAAGAAAAGCAGATAACTTGTTGGGGAGATAATATCCAAGCAGTTGAAGTTGAAGTTGAAGGAGTTTTTGA
TGACTGTCAAAGTCTAGTCAAAGAAGCTTTTAAGACACCTTGGTGGACAGAGAGGACTAAGTTAAATACATCAAATAGTA
TTAATATCGGTAGATTACTATCACAATCAACTTATTATGCTTATACATCGTGGCAACATTATTTGCAGACCGGAGAGAAA
GCAAACTATATAGTTCCATCTGGCAATATTGGTAATATAACTGCTGCTTTTTGGGCAAAGCAAATGGGCTTTCCAATAGG
TGAAATATCGATGAGTTTAAATGCTAATGATACTGTTGTTGACTATCTAGAGACTGGTAAGTTTAATCCTAAGGCAAGTG
TTGAAACGCTAGCAAATGCTATGGATGTTGGTAACCCTAGTAATTTTGAAAGATTGTTATACTTGTTGGGTAATTATGAA
AATTTCAAAGCTAATGTTAAGGCTATATGTGTTTCTGACTTTGAAATTATAGAAGAAATAAAACAAGTGTATCGTCAATA
TCATGAAGTTGTTTGTCCACACACAGCAACAGGTTTTGTAGCAAAAAATCAGTTAGATAGCAATAAAGATTATATAATCG
TAGCAACTGCACATCCTGCTAAGTTTGAAAGTGTAATTGAGCCTATATTAGATATACAAGTGCCGCCTACACCGGCGTTA
CAAAAGCTACTAGACAAAGAGCAAAATAAAGTAGTTATAAATAAGTCTATGGATGAGCTGTGCGAGGTTTATACAAAAGC
TTTTGAAGCTTAG

Upstream 100 bases:

>100_bases
AGATAAGTTTAAAGAGTTTAACTTAAACTCTAATAGTTGGATAAGTGCTATGAGTGACAAAGGCGCGTATATATTAGAGA
AAAAATGATAAAGGTAAAGC

Downstream 100 bases:

>100_bases
CTTAAAAGCGGATGTGATCTGATTTTCAGGTCTTTCTTTAACAATAAAAGGTATTACTGCTATAGTGGGAACTATTAAGA
GCAAGCAGACAACAATACAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNFISTRDKNIKVSLSEAMQSGLALDGGLFVPERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLSQSTYYAYTSWQHYLQTGEK
ANYIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYE
NFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTATGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPAL
QKLLDKEQNKVVINKSMDELCEVYTKAFEA

Sequences:

>Translated_430_residues
MNFISTRDKNIKVSLSEAMQSGLALDGGLFVPERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLSQSTYYAYTSWQHYLQTGEK
ANYIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYE
NFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTATGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPAL
QKLLDKEQNKVVINKSMDELCEVYTKAFEA
>Mature_430_residues
MNFISTRDKNIKVSLSEAMQSGLALDGGLFVPERFPTVNWQSFAKDISYAKFAANTLREFFKGDQLEDSLDKICNNAFTF
EAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSIDSEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKI
SKRQEKQITCWGDNIQAVEVEVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLSQSTYYAYTSWQHYLQTGEK
ANYIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANAMDVGNPSNFERLLYLLGNYE
NFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTATGFVAKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPAL
QKLLDKEQNKVVINKSMDELCEVYTKAFEA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=457, Percent_Identity=33.0415754923414, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI149193323, Length=470, Percent_Identity=29.5744680851064, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786185, Length=398, Percent_Identity=38.4422110552764, Blast_Score=254, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6319901, Length=454, Percent_Identity=32.8193832599119, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48076; Mature: 48076

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFISTRDKNIKVSLSEAMQSGLALDGGLFVPERFPTVNWQSFAKDISYAKFAANTLREF
CCCCCCCCCCEEEEHHHHHHCCCEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FKGDQLEDSLDKICNNAFTFEAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSID
HCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKISKRQEKQITCWGDNIQAVEV
CCCCEEEEEEECCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEE
EVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLSQSTYYAYTSWQHYLQTGEK
EECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHCCCC
ANYIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANA
CCEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHH
MDVGNPSNFERLLYLLGNYENFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTATGFV
HCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCE
AKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQKLLDKEQNKVVINKSMDEL
ECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCHHHH
CEVYTKAFEA
HHHHHHHHCC
>Mature Secondary Structure
MNFISTRDKNIKVSLSEAMQSGLALDGGLFVPERFPTVNWQSFAKDISYAKFAANTLREF
CCCCCCCCCCEEEEHHHHHHCCCEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FKGDQLEDSLDKICNNAFTFEAPVRRLDKTTSVLELFHGPTLSFKDFGARFLANCLSSID
HCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SEKPFTILVATSGDTGSAVAAAFHGKSNIRVIVMFPKGKISKRQEKQITCWGDNIQAVEV
CCCCEEEEEEECCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEE
EVEGVFDDCQSLVKEAFKTPWWTERTKLNTSNSINIGRLLSQSTYYAYTSWQHYLQTGEK
EECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHCCCC
ANYIVPSGNIGNITAAFWAKQMGFPIGEISMSLNANDTVVDYLETGKFNPKASVETLANA
CCEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHH
MDVGNPSNFERLLYLLGNYENFKANVKAICVSDFEIIEEIKQVYRQYHEVVCPHTATGFV
HCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCE
AKNQLDSNKDYIIVATAHPAKFESVIEPILDIQVPPTPALQKLLDKEQNKVVINKSMDEL
ECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCHHHH
CEVYTKAFEA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]