Click here to switch to the map view.

The map label for this gene is gcvPA [H]

Identifier: 89255889

GI number: 89255889

Start: 456703

End: 458070

Strand: Direct

Name: gcvPA [H]

Synonym: FTL_0479

Alternate gene names: 89255889

Gene position: 456703-458070 (Clockwise)

Preceding gene: 89255888

Following gene: 89255890

Centisome position: 24.09

GC content: 36.4

Gene sequence:

>1368_bases
ATGTCTTTTATCCCGCATAAACTAGAACAAATCAAAAAAATGCTTGATACTATAGGAGCTAGTTCTGTAGATCAGTTATT
TGATGAGATTCCAAGACACTTAAGGGCTGATACTCTTAATATTAAAGATGGTATCAATGAGATTCAATTAGCAAATCTTA
TGAGAAAGAGAGCTAATAAAAATCATCATAATATAAATTATATAGGTGCTGGTGCCTATAGTCACCATATTCCAGCTGCG
ATATGGGATATCGTAGCTCGTGGCGAGTTCTATACTGCATATACACCATATCAAGCAGAGGCTTCACAAGGTGGTTTGCA
AGTTATCTATGAATTTCAAACTATGATGGCAGGGCTAACAGGTATGGATGCCTCAAATGCGTCTATGTATGATGGCGCAA
CTGCTTTAGCCGAGTCGGTACTTATGGCGATTCGCTCAAACAAAAAAGCAAAGTCACAAAAGGTTTTGATTGCTGAAGCT
TTACACCCAACTTATTTGAGAGTATTAGAAACTATAACAAAGCATCAAGGTATAGAGTTTGATATTGTTAATCTTGATTC
TAAAAATGGTAAGACAGACGTTACAAAGTTAGAAGATTTTGCTAATACCAATTATGCAGCTGTAGTTATCCAAAGTCCTA
ATTTCTTAGGTCAACTTGCAGATGTTGATGGGATTACAAATTGGGCACATAAGCATGGAGCTTTGGTTATTGCAGTTACT
AATCCTATGTCGCTTGCAATATTAAAATCACCAGCGGAATGGGGTGATAATGGTGCTGATATAGTATGTGGTGAGGGTCA
ACCTATTGGTGTGCCTTTAGCTTCTGGAGGTCCATATTTTGGTTTTATGACTTGTAAGATGGCTCATGTACGTCAAATGC
CAGGGCGTATAGTTGGTAGAACTGTTGATTTAGATGGAAATGAAGGTTTTTGTTTGACGCTACAAGCAAGAGAACAACAT
ATCCGTCGCGCTAAAGCTACTTCAAATATCTGTACTAACCAAGGCTTGATGGTTACAGCGGCAACTATTTATATGAGCTT
ACTAGGTGCTGAAGGTTTAGAAAGAGTAGCTAGTATTTCTCATGAAAATACACAAACTTTAGCGACTGAATTAGCTAAAA
TAAACGGGGTAAGCATTAGATTTAATAGTGCTTTCTTTAATGAAGTAGTAATCGATTTACCTGTAAATGCTGAAACTTTT
GTAACAGAGATGGAAAAAGAAGCTATTGATGCAGGTTACTTTTTAGGGGAATATCATAGTGATTTAGCTAACTCTATTAT
GGTTTGTGCTACAGAGATTCATACATCTGAAGATATCAAAGAGTATATAGAAGCTACTAAAAAAGTTTTAGCTAGGATAG
GAGGTTAA

Upstream 100 bases:

>100_bases
ACAGCTGATGCTTATGCAAAAACTCTTGAGGATTAATTGTGTAAACACAAAAACTATTTTTAATCTTTTATAAAATCTTG
TACAAAGACATGGAGGAAAT

Downstream 100 bases:

>100_bases
TTTAAATGGTTATTTTTGAAAAAACTAGAGGTAAAAACTCGCCATCTGTAATGCCTAGCAAAAAAGGAGATGTTTCAAAT
ATCCCTACAGATATGCTACG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANKNHHNINYIGAGAYSHHIPAA
IWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLTGMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEA
LHPTYLRVLETITKHQGIEFDIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVT
NPMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGRTVDLDGNEGFCLTLQAREQH
IRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASISHENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETF
VTEMEKEAIDAGYFLGEYHSDLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG

Sequences:

>Translated_455_residues
MSFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANKNHHNINYIGAGAYSHHIPAA
IWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLTGMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEA
LHPTYLRVLETITKHQGIEFDIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVT
NPMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGRTVDLDGNEGFCLTLQAREQH
IRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASISHENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETF
VTEMEKEAIDAGYFLGEYHSDLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG
>Mature_454_residues
SFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANKNHHNINYIGAGAYSHHIPAAI
WDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLTGMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEAL
HPTYLRVLETITKHQGIEFDIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVTN
PMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGRTVDLDGNEGFCLTLQAREQHI
RRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASISHENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETFV
TEMEKEAIDAGYFLGEYHSDLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=370, Percent_Identity=35.4054054054054, Blast_Score=225, Evalue=7e-59,
Organism=Escherichia coli, GI1789269, Length=436, Percent_Identity=32.3394495412844, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17535605, Length=448, Percent_Identity=36.6071428571429, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=393, Percent_Identity=35.1145038167939, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24645648, Length=385, Percent_Identity=38.1818181818182, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49667; Mature: 49536

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANK
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCC
NHHNINYIGAGAYSHHIPAAIWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLT
CCCCEEEEECCCHHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEALHPTYLRVLETITKHQGIEF
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
DIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVT
EEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHCCEEEEEEC
NPMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGR
CCEEEEEEECCHHHCCCCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCHHCCE
TVDLDGNEGFCLTLQAREQHIRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASIS
EEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
HENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETFVTEMEKEAIDAGYFLGEYHS
CCCHHHHHHHHHHHCCEEEEECCEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG
HHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLNIKDGINEIQLANLMRKRANK
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCC
NHHNINYIGAGAYSHHIPAAIWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLT
CCCCEEEEECCCHHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEALHPTYLRVLETITKHQGIEF
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
DIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVT
EEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHCCEEEEEEC
NPMSLAILKSPAEWGDNGADIVCGEGQPIGVPLASGGPYFGFMTCKMAHVRQMPGRIVGR
CCEEEEEEECCHHHCCCCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCHHCCE
TVDLDGNEGFCLTLQAREQHIRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASIS
EEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
HENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETFVTEMEKEAIDAGYFLGEYHS
CCCHHHHHHHHHHHCCEEEEECCEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG
HHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA