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The map label for this gene is map [H]

Identifier: 89255869

GI number: 89255869

Start: 433260

End: 434030

Strand: Direct

Name: map [H]

Synonym: FTL_0459

Alternate gene names: 89255869

Gene position: 433260-434030 (Clockwise)

Preceding gene: 89255865

Following gene: 89255870

Centisome position: 22.85

GC content: 36.32

Gene sequence:

>771_bases
ATGAGTCAAATAATAATAAAAACTTCTCAAGAAATAGAAAAGATGCGCGTTGCTGGTAGACTAGCAGCAGAAGTTTTAGA
GATGATTACTCCTTTTGTTAAAGAAGGAGTTACAACCGCAGAGCTTGATAAAATTTGTCATGAATATATAGTCAAAGAGC
AAGATGCATATCCAGCGCCGCTTAATTACCATGGGTTTCCTAAATCAATTTGTACTTCAATAAATCATGTTGTTTGTCAT
GGAATTCCAGCTGATAAGAAGCTTAAAAATGGTGATATATTAAATATCGATATTACAGTTAAAAAAGATGGCTATCATGG
TGATACAAGTAAGATGTTTATGATAGGTGAGCCATCAGTCATGGCTAAAAAACTAGTAGAAGTTACTCATGAATGCTTAT
GGAAAGGTATAGAAGTAGTTAAACCTGGCAATCATTTTGGCGATATCGGCGCAGCTATAGAAAAGCATGCTAAGAAGTTT
GGTTATTCGATAGTTGATGCTTTTTGTGGCCATGGGATAGGTGCTAATTTCCATGAACCACCGCATGTTATGCATCATGG
TAAAGCTGGTATAGGCGCAATGTTTGAAGAAGGAATGATATTTACAATCGAACCGATGATAAATATCGGTAAAAGAGCAG
TGTCAGTGCTAAAAGATGGTTGGACTGCTGTTACAAAAGACCGTTCACTCTCAGCACAGTGGGAGCATACAATTTTGGTT
ACAAAAGATGGTTATGAAGTCCTAACACTAAGAGAAGAAGAAAAAAACTAG

Upstream 100 bases:

>100_bases
AATTTGCAATAATTTTAACATCCTTTTGTAAGATCTATATATTCATAAACTGATGGTTTATAATGTATGATTAGATTTTA
TTAAAAAATACTGATTACAG

Downstream 100 bases:

>100_bases
TATGCCAAAACAAGTAACTCAAAAACTGGTAAATCAAAAGTGTGATCTTTTAAGATCTCAAAATGAAGAGATTACTGTCA
GTAAAGTTAGAAAGCTGATT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSQIIIKTSQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAPLNYHGFPKSICTSINHVVCH
GIPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEPSVMAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKF
GYSIVDAFCGHGIGANFHEPPHVMHHGKAGIGAMFEEGMIFTIEPMINIGKRAVSVLKDGWTAVTKDRSLSAQWEHTILV
TKDGYEVLTLREEEKN

Sequences:

>Translated_256_residues
MSQIIIKTSQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAPLNYHGFPKSICTSINHVVCH
GIPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEPSVMAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKF
GYSIVDAFCGHGIGANFHEPPHVMHHGKAGIGAMFEEGMIFTIEPMINIGKRAVSVLKDGWTAVTKDRSLSAQWEHTILV
TKDGYEVLTLREEEKN
>Mature_255_residues
SQIIIKTSQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAPLNYHGFPKSICTSINHVVCHG
IPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEPSVMAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKFG
YSIVDAFCGHGIGANFHEPPHVMHHGKAGIGAMFEEGMIFTIEPMINIGKRAVSVLKDGWTAVTKDRSLSAQWEHTILVT
KDGYEVLTLREEEKN

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=48.4, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=44.1295546558704, Blast_Score=213, Evalue=1e-55,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=59.5238095238095, Blast_Score=322, Evalue=1e-89,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=24.2063492063492, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=254, Percent_Identity=46.8503937007874, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6323273, Length=255, Percent_Identity=44.3137254901961, Blast_Score=228, Evalue=7e-61,
Organism=Drosophila melanogaster, GI21355531, Length=252, Percent_Identity=48.015873015873, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=47.1311475409836, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28392; Mature: 28261

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIIIKTSQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAP
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
LNYHGFPKSICTSINHVVCHGIPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEPSV
CCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCCHH
MAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKFGYSIVDAFCGHGIGANFHEP
HHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PHVMHHGKAGIGAMFEEGMIFTIEPMINIGKRAVSVLKDGWTAVTKDRSLSAQWEHTILV
CHHHHCCCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEE
TKDGYEVLTLREEEKN
ECCCCEEEEEECCCCC
>Mature Secondary Structure 
SQIIIKTSQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAP
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
LNYHGFPKSICTSINHVVCHGIPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEPSV
CCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCCHH
MAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKFGYSIVDAFCGHGIGANFHEP
HHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PHVMHHGKAGIGAMFEEGMIFTIEPMINIGKRAVSVLKDGWTAVTKDRSLSAQWEHTILV
CHHHHCCCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEE
TKDGYEVLTLREEEKN
ECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]