Click here to switch to the map view.

The map label for this gene is murQ

Identifier: 89255730

GI number: 89255730

Start: 285992

End: 286876

Strand: Direct

Name: murQ

Synonym: FTL_0299

Alternate gene names: 89255730

Gene position: 285992-286876 (Clockwise)

Preceding gene: 89255729

Following gene: 89255731

Centisome position: 15.08

GC content: 33.33

Gene sequence:

>885_bases
ATGAATATCTTAGAAAATATTAATACAGAAAAAAGAAATCCTAGAAGTTTAAATCTTGATTCCATGTCTATAGCTGAAGC
AGTTAGCTTAATGATAGATGAGGAGTATGGTGTAATTGAAGCACTAAAAGAACAGCATAGAAATATAACAGAGGTAATTT
TGGCAACATCTTATTCCCTAAGAAATGGTGGCAGGATTATATATATTGGTGCAGGTACAAGTGGTAGATTAGGTATATTA
GATGCCGTTGAATGTCCACCAACATTTAGTGTTGATTATAATACAATTGTAGGCTTGATAGCTGGTGGTGAAAAGGCATT
TATTCAAGCTCAAGAAGGAGCTGAAGATGCTGCTAATTTTGGTAAAGAAGATTTGCAGAGCATAAATCTTACAGCTAAAG
ATATTGTAATAGGTATTGCTGCTAGTGGTAGGACTCCATATGTGATTGGTGCTCTTGAGTATGCTAACTCTATTGGTGCG
ACTACAGTTGCTATTAGTTGTACTAAACAAGCAAAAATATCAAAATATGCTAAATACTCTATAGAGGCAGTACCAGGACC
TGAAGTTTTAACAGGTTCAACAAGGCTAAAGGCTGGTACTACTCAAAAGCTGATTCTCAATATGATATCAACTCTTTCAA
TGGTCTCTGTCGGTAAAGTTTATCAAAATCTGATGGTAGATGTAAAACCTACTAACCAAAAGCTAATTGAACGCTCAAAG
AATATTATCTGTGAAGTTACGGGAGTAGATTATACAACTGCGGAGAAATTTTACTTAAAAGCCAATAAATCTGTCAAGGT
TGCAATAGTAATGATATTAAATAATTGTGATTATGAAAAAGCTTTGGCAATATTAAAGAACAATAATAATTTTATAAAGA
GCTAA

Upstream 100 bases:

>100_bases
ATGCTAAAGCTAAAGATGAAGAAGACAATCAACCAGCAGAACGTATATATTTAGACACTAAGTATCTTTATCCTTTGGGG
ATAGTCAAGGAAGTTAAATT

Downstream 100 bases:

>100_bases
GATGAGATTATTAATATTGTTTATAGCCGTTATGTTTAGTTTTGATAGCTATGCTACTATTTATGAAAAATATCAAAATG
GTGTGCCAGAATTTTCTAAT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNILENINTEKRNPRSLNLDSMSIAEAVSLMIDEEYGVIEALKEQHRNITEVILATSYSLRNGGRIIYIGAGTSGRLGIL
DAVECPPTFSVDYNTIVGLIAGGEKAFIQAQEGAEDAANFGKEDLQSINLTAKDIVIGIAASGRTPYVIGALEYANSIGA
TTVAISCTKQAKISKYAKYSIEAVPGPEVLTGSTRLKAGTTQKLILNMISTLSMVSVGKVYQNLMVDVKPTNQKLIERSK
NIICEVTGVDYTTAEKFYLKANKSVKVAIVMILNNCDYEKALAILKNNNNFIKS

Sequences:

>Translated_294_residues
MNILENINTEKRNPRSLNLDSMSIAEAVSLMIDEEYGVIEALKEQHRNITEVILATSYSLRNGGRIIYIGAGTSGRLGIL
DAVECPPTFSVDYNTIVGLIAGGEKAFIQAQEGAEDAANFGKEDLQSINLTAKDIVIGIAASGRTPYVIGALEYANSIGA
TTVAISCTKQAKISKYAKYSIEAVPGPEVLTGSTRLKAGTTQKLILNMISTLSMVSVGKVYQNLMVDVKPTNQKLIERSK
NIICEVTGVDYTTAEKFYLKANKSVKVAIVMILNNCDYEKALAILKNNNNFIKS
>Mature_294_residues
MNILENINTEKRNPRSLNLDSMSIAEAVSLMIDEEYGVIEALKEQHRNITEVILATSYSLRNGGRIIYIGAGTSGRLGIL
DAVECPPTFSVDYNTIVGLIAGGEKAFIQAQEGAEDAANFGKEDLQSINLTAKDIVIGIAASGRTPYVIGALEYANSIGA
TTVAISCTKQAKISKYAKYSIEAVPGPEVLTGSTRLKAGTTQKLILNMISTLSMVSVGKVYQNLMVDVKPTNQKLIERSK
NIICEVTGVDYTTAEKFYLKANKSVKVAIVMILNNCDYEKALAILKNNNNFIKS

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=290, Percent_Identity=48.2758620689655, Blast_Score=260, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_FRATH (Q2A5B0)

Other databases:

- EMBL:   AM233362
- RefSeq:   YP_513091.1
- ProteinModelPortal:   Q2A5B0
- SMR:   Q2A5B0
- GeneID:   3950861
- GenomeReviews:   AM233362_GR
- KEGG:   ftl:FTL_0299
- HOGENOM:   HBG703490
- OMA:   HLLTEQI
- ProtClustDB:   PRK05441
- BioCyc:   FTUL351581:FTL_0299-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31812; Mature: 31812

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS01272 GCKR; PS51464 SIS; PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 84-84 ACT_SITE 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILENINTEKRNPRSLNLDSMSIAEAVSLMIDEEYGVIEALKEQHRNITEVILATSYSL
CCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHEECEEE
RNGGRIIYIGAGTSGRLGILDAVECPPTFSVDYNTIVGLIAGGEKAFIQAQEGAEDAANF
CCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCCEEEEEECCCCHHHHHC
GKEDLQSINLTAKDIVIGIAASGRTPYVIGALEYANSIGATTVAISCTKQAKISKYAKYS
CHHHHHHCCCEEHHEEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEECCHHHHHHHHHEE
IEAVPGPEVLTGSTRLKAGTTQKLILNMISTLSMVSVGKVYQNLMVDVKPTNQKLIERSK
EEECCCCCEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHCCC
NIICEVTGVDYTTAEKFYLKANKSVKVAIVMILNNCDYEKALAILKNNNNFIKS
CEEEEEECCCCCCCCEEEEEECCCEEEEEEEEECCCCHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MNILENINTEKRNPRSLNLDSMSIAEAVSLMIDEEYGVIEALKEQHRNITEVILATSYSL
CCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHEECEEE
RNGGRIIYIGAGTSGRLGILDAVECPPTFSVDYNTIVGLIAGGEKAFIQAQEGAEDAANF
CCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCCEEEEEECCCCHHHHHC
GKEDLQSINLTAKDIVIGIAASGRTPYVIGALEYANSIGATTVAISCTKQAKISKYAKYS
CHHHHHHCCCEEHHEEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEECCHHHHHHHHHEE
IEAVPGPEVLTGSTRLKAGTTQKLILNMISTLSMVSVGKVYQNLMVDVKPTNQKLIERSK
EEECCCCCEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHCCC
NIICEVTGVDYTTAEKFYLKANKSVKVAIVMILNNCDYEKALAILKNNNNFIKS
CEEEEEECCCCCCCCEEEEEECCCEEEEEEEEECCCCHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA