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The map label for this gene is relA [H]

Identifier: 89255717

GI number: 89255717

Start: 270021

End: 271964

Strand: Direct

Name: relA [H]

Synonym: FTL_0285

Alternate gene names: 89255717

Gene position: 270021-271964 (Clockwise)

Preceding gene: 89255716

Following gene: 89255720

Centisome position: 14.24

GC content: 34.1

Gene sequence:

>1944_bases
ATGCAAGTTATTGACTCTAAACTTCTAGATAGTGATGGTCAGATAAAAGATGAGCTTTTGATATCTGAGCTTAAAAGTTT
TTATACTAGTGACAAGTTTGAGATTATAGCTGCAGCTCTAGAATTACTTAAGAATAAAAGTGCTGAATCTGTGCGTCACC
CTACAGGTATTAGCTCATTTTTATATGCTATCGAGATGGCATATGTACTTTTCAAAATTAGAGCAGATGAAGAGTCTGTT
TCTGCAGGTATCCTTTATGAATTGTATAATTTTGGTGATATATCTGATGAAGATATCGAGCAGGCTACTAATCAAACAGT
GCTTAAGATTTTACAAGGCACGCGAAAAATGTCTGCTATTAGAATGTATCGCTCAGATAATATTTCCTTAGAGCAAATTG
ATACATTTAGGAAAATGCTATTGACAATTATTGAAGATGTCAGAATTGTTTTAGTAAAGATTGTCGACAAACTGTGTACA
ATTCGCCATTTAAAATCTCTAAGTAGTAATACCCAACGAGTTATTGCTAGGGAAACATTAGATATCTATGCGCCATTGGC
AAATAGACTTGGCTTAGGTGCCATCAAATGGGAGCTAGAAGATAGAGCATTTTTCTTTTTACAGCAAGATGAATACAAAC
GAATAGCTAAAAGTTTAGGTGTGACGCGAAAACAGCGTGAAGATTTCCTGCATCAAGTAATCCAGGAATTAAAGTCAACG
CTCAAAAAATACAACTTACATGCTGGTATTCAAGGTAGAGTTAAGCATATCTATAGTATCTACAAGAAGTTTAAGAATAA
AGGTTACCAAGAACTTGATGATTTATATGATATTACAGCTGTTAGGGTTATCACAAATAATGTTGATGAGTGTTATAAAG
TACTTGCTGAGGTTAATAATTTATATTCACCAATACCTGAAGAATTTAGTGATTATATTGCTCACCCTAAGCCAAATGGT
TACAAATCAATACATACAGTTGTCAAAGTTGGCGAGCAGAATATTGAGGTTCAAATTAGAACCCAACAAATGCATGAAGA
ATCTGAGTTGGGTTTTGCGGCACATTGGCGTTATAAGGAAGGTGTTAAATTTGATGCTTCTTATGAGGCTAGGGTTGCTT
GGTTAAGATCTCTTCTTGAATGGGAGAAAGAGATTAATGAAGATGATAGTCAAATCACAAAAGAGCTTAATAAAAAGCTT
TATGTATTTACGCCAGCAAATGAGCTAATAGATTTAGCTGAAGGTTCGACAGTCTTAGATTTTGCTTATTCAGTACATAC
TATGGTTGGTCACCGTACTAAAGGCGCTAAACTAAATGGTAAGATAGTACCGTTAACAACTAAGCTAAAGACTGGTGATA
AAGTTGAGATTCTAACAGGTAAAGAACCTAATCCAAGTAAAGATTGGGCATCAGAAAATTTAGGTTATTTAACTTCTGCA
CGGAATAGATCAAGAGTCACCAAATGGTTTAATGAGCAGAATAAAGAAGATAATATAGCTTTAGGAAAAGATCGCCTTCT
AAAAGAGCTAAGAGGTTATGACCTTAAAGAGGTCGATTTTGTTGAAGTTGCTGCTAAGTTTAATATGAAAACTAGTGATA
GTCTTTTTGCAGCGATTGAGGGTGGAAGTTTAAAGACTAATAGCGTTGTTAATTATATTATTGATACTTATTCAGCAGAA
GAGAAATTAATCAAGAAAAAGCATAAAGTAACAAACTTAAAAGCTAAAGCCCCAAAAGTCTTAGTTTCCGGTTTTGATGG
TATGAAATATGAGATGGCTAAGTGCTGCCATCCTGTTTATCCTGATCAAATTCAAGGTTATATGAGTGTTTCAAAAGGAG
TAGTTATTCATACTACAAACTGTCCTAATCTAAATCACCTCAAAGAAAAAAGTCCTGAGAAATTTATAGAGGTTAATTGG
GATGATAATGAAGAGGTCTGCTAA

Upstream 100 bases:

>100_bases
GCTTGAGCTTATTGGTGACAATAGGCCTAGATAAATGACTGTCTATTACAGAACCCGGCTTATAGACTGGCTTTGTATTT
TTTACAAAAAGTGGGTAATT

Downstream 100 bases:

>100_bases
TAATTAACAAAAACTAATTTAATAGTATAAAATGTCAACTAGTATGCTAAGTTAGAAAAAATTTATCAAATTTGGTTTAT
TGAATGAAAGTTTATATTTA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSFLYAIEMAYVLFKIRADEESV
SAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAIRMYRSDNISLEQIDTFRKMLLTIIEDVRIVLVKIVDKLCT
IRHLKSLSSNTQRVIARETLDIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKST
LKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNNLYSPIPEEFSDYIAHPKPNG
YKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKEGVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKL
YVFTPANELIDLAEGSTVLDFAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSA
RNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIEGGSLKTNSVVNYIIDTYSAE
EKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVYPDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNW
DDNEEVC

Sequences:

>Translated_647_residues
MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSFLYAIEMAYVLFKIRADEESV
SAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAIRMYRSDNISLEQIDTFRKMLLTIIEDVRIVLVKIVDKLCT
IRHLKSLSSNTQRVIARETLDIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKST
LKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNNLYSPIPEEFSDYIAHPKPNG
YKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKEGVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKL
YVFTPANELIDLAEGSTVLDFAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSA
RNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIEGGSLKTNSVVNYIIDTYSAE
EKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVYPDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNW
DDNEEVC
>Mature_647_residues
MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSFLYAIEMAYVLFKIRADEESV
SAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAIRMYRSDNISLEQIDTFRKMLLTIIEDVRIVLVKIVDKLCT
IRHLKSLSSNTQRVIARETLDIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKST
LKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNNLYSPIPEEFSDYIAHPKPNG
YKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKEGVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKL
YVFTPANELIDLAEGSTVLDFAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSA
RNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIEGGSLKTNSVVNYIIDTYSAE
EKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVYPDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNW
DDNEEVC

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=614, Percent_Identity=38.1107491856677, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1790082, Length=629, Percent_Identity=31.4785373608903, Blast_Score=339, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 74085; Mature: 74085

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSF
CCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
LYAIEMAYVLFKIRADEESVSAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAI
HHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RMYRSDNISLEQIDTFRKMLLTIIEDVRIVLVKIVDKLCTIRHLKSLSSNTQRVIARETL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKST
HHHHHHHHHCCCCEEEEEECCCEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNN
HHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LYSPIPEEFSDYIAHPKPNGYKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKE
HHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCEEEECCHHC
GVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKLYVFTPANELIDLAEGSTVLD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECHHHHHHHCCCCCHHH
FAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSA
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCHHHCC
RNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIE
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
GGSLKTNSVVNYIIDTYSAEEKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCCC
PDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNWDDNEEVC
HHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSF
CCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
LYAIEMAYVLFKIRADEESVSAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAI
HHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RMYRSDNISLEQIDTFRKMLLTIIEDVRIVLVKIVDKLCTIRHLKSLSSNTQRVIARETL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKST
HHHHHHHHHCCCCEEEEEECCCEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNN
HHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LYSPIPEEFSDYIAHPKPNGYKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKE
HHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCEEEECCHHC
GVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKLYVFTPANELIDLAEGSTVLD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECHHHHHHHCCCCCHHH
FAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSA
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCHHHCC
RNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIE
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
GGSLKTNSVVNYIIDTYSAEEKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCCC
PDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNWDDNEEVC
HHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]