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The map label for this gene is fumC [H]

Identifier: 89255651

GI number: 89255651

Start: 216725

End: 218116

Strand: Direct

Name: fumC [H]

Synonym: FTL_0217

Alternate gene names: 89255651

Gene position: 216725-218116 (Clockwise)

Preceding gene: 89255650

Following gene: 89255652

Centisome position: 11.43

GC content: 35.49

Gene sequence:

>1392_bases
TTGCGTAGAGTAGAAACAGACAGTACTGGTCAAATAGAAGTTGATAATGACAAATATTGGGGTGCACAAACACAGCGATC
TATAGAGCATTTTTCTATAGGCAGTGATTTGATGCCGATCGAAGTTATTAAAGCTTTGGCAATTATCAAAAAAGCTGCAG
CTATCACAAATCATCAGTTAGGTATCTTAGCGCGAACTAAAAAAGAAATTATCATTAAAGTCGCAGATGAGATAATTGCA
GGAGAACTTGATGAGCATTTTCCATTACGTGTTTTTATGACTGGAAGTGGTACACAATCAAATATGAATATTAATGAAGT
GATTTCAAATAGGGCTATTGAGCTTCTAGGAGGCAAAAAGGGGAGTAAAAATCCTATCCATCCAAATGATGATGTTAATA
TGTCTCAATCATCAAATGACACTTTTCCAAGTGCGATGTATATTGCTACCGCCCTTGAGATAAATAACAGACTTTTACCT
GCTCTTGAGTATATGCAACAACAATTAGCTGACAAAGCAAAGCAATGGGATGATATTGTCAAAATTGGTAGGACACATAT
GCAAGATGCTGTGCCACTAACTTTAGGTCAAGAGTTCTCTGGTTATGCGGCATTATTAGAAAATAATATTCAAAGAATCA
AAGATACATTAAAATATGTATATCAGCTTGCTCTTGGCGGCACGGCTGTTGGTACAGGATTAAATGCTCCTGATGGTTTT
GCTGAGATCACAGCAAAATATATCGCTACTATTACAAGTTTAGCATTTGTTTCAGCTACTAATAAATTTGAAGTACAAGG
CTCACATGACGCTTTAGTTGCAGTTATGGGACAACTTAAAACTTTAGCTAATTCGTTATTTAAGATTGCTAATGATATTC
GTTTACTAAGTTGTGGACCAAGAGCTGGTTTTCATGAGTTACTAATCCCAGAAAATGAGCCAGGCTCATCAATTATGCCA
GGAAAGGTTAATCCCACTCAATGTGAAGCTATGGCAATGGTTGCAGCTCAAGTTATCGGTTATGATGTTGCAGTTGGTAT
AGGTGGTTCAGCAGGTTATCTTGAGATGAATGTCTATAAGCCATTGATTATTTTTAATATCATTCAATCGATTAAGATTA
TCTCAGATAGCTGTGTAAATTTTACAAAGTATCTTTTAGAAGGGATGAAGCCAAATCACGATAAAATAGAGTTTTATCTC
AAAAATTCACTGATGCTTGTGACTGCTCTTAGCCCTGTAATAGGCTATGATAAGGCAGCAAAACTAGCCCATTATGCTGA
GCAAAAAAATATCTCCTTGGCTGAGGCAAATCAAGAGCTTAAATTTTTATCAAAAGAAGAATTTGATAAAGTTGTTGATC
CTTATAAAATGACTAAAGGTGGTATCTTATAA

Upstream 100 bases:

>100_bases
AGCATATTTTGTTTTTGTAGTTTTTGAATGTTATATTTGATAGTTAGCTGTAGTAGCTATATGATTTCTGATGTTATTTT
GGTTCTTTAGGAGATAAGTT

Downstream 100 bases:

>100_bases
GTATTAATTTTTTCAAAAATAATATCTTAATTAGATCTATTAACACTTATTAATCGTTTGCTTTAATCCTTGAAAGAAAC
TCGTTTCTAGTTTAATCTTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 2 [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRRVETDSTGQIEVDNDKYWGAQTQRSIEHFSIGSDLMPIEVIKALAIIKKAAAITNHQLGILARTKKEIIIKVADEIIA
GELDEHFPLRVFMTGSGTQSNMNINEVISNRAIELLGGKKGSKNPIHPNDDVNMSQSSNDTFPSAMYIATALEINNRLLP
ALEYMQQQLADKAKQWDDIVKIGRTHMQDAVPLTLGQEFSGYAALLENNIQRIKDTLKYVYQLALGGTAVGTGLNAPDGF
AEITAKYIATITSLAFVSATNKFEVQGSHDALVAVMGQLKTLANSLFKIANDIRLLSCGPRAGFHELLIPENEPGSSIMP
GKVNPTQCEAMAMVAAQVIGYDVAVGIGGSAGYLEMNVYKPLIIFNIIQSIKIISDSCVNFTKYLLEGMKPNHDKIEFYL
KNSLMLVTALSPVIGYDKAAKLAHYAEQKNISLAEANQELKFLSKEEFDKVVDPYKMTKGGIL

Sequences:

>Translated_463_residues
MRRVETDSTGQIEVDNDKYWGAQTQRSIEHFSIGSDLMPIEVIKALAIIKKAAAITNHQLGILARTKKEIIIKVADEIIA
GELDEHFPLRVFMTGSGTQSNMNINEVISNRAIELLGGKKGSKNPIHPNDDVNMSQSSNDTFPSAMYIATALEINNRLLP
ALEYMQQQLADKAKQWDDIVKIGRTHMQDAVPLTLGQEFSGYAALLENNIQRIKDTLKYVYQLALGGTAVGTGLNAPDGF
AEITAKYIATITSLAFVSATNKFEVQGSHDALVAVMGQLKTLANSLFKIANDIRLLSCGPRAGFHELLIPENEPGSSIMP
GKVNPTQCEAMAMVAAQVIGYDVAVGIGGSAGYLEMNVYKPLIIFNIIQSIKIISDSCVNFTKYLLEGMKPNHDKIEFYL
KNSLMLVTALSPVIGYDKAAKLAHYAEQKNISLAEANQELKFLSKEEFDKVVDPYKMTKGGIL
>Mature_463_residues
MRRVETDSTGQIEVDNDKYWGAQTQRSIEHFSIGSDLMPIEVIKALAIIKKAAAITNHQLGILARTKKEIIIKVADEIIA
GELDEHFPLRVFMTGSGTQSNMNINEVISNRAIELLGGKKGSKNPIHPNDDVNMSQSSNDTFPSAMYIATALEINNRLLP
ALEYMQQQLADKAKQWDDIVKIGRTHMQDAVPLTLGQEFSGYAALLENNIQRIKDTLKYVYQLALGGTAVGTGLNAPDGF
AEITAKYIATITSLAFVSATNKFEVQGSHDALVAVMGQLKTLANSLFKIANDIRLLSCGPRAGFHELLIPENEPGSSIMP
GKVNPTQCEAMAMVAAQVIGYDVAVGIGGSAGYLEMNVYKPLIIFNIIQSIKIISDSCVNFTKYLLEGMKPNHDKIEFYL
KNSLMLVTALSPVIGYDKAAKLAHYAEQKNISLAEANQELKFLSKEEFDKVVDPYKMTKGGIL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=457, Percent_Identity=55.7986870897155, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI266458395, Length=85, Percent_Identity=45.8823529411765, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787896, Length=455, Percent_Identity=53.8461538461538, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI87082375, Length=452, Percent_Identity=37.3893805309735, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17553882, Length=457, Percent_Identity=57.5492341356674, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=57.0987654320988, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324993, Length=457, Percent_Identity=55.5798687089716, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24640179, Length=458, Percent_Identity=56.5502183406114, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24640177, Length=458, Percent_Identity=56.5502183406114, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=54.9019607843137, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=53.4782608695652, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=48.5838779956427, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50717; Mature: 50717

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVETDSTGQIEVDNDKYWGAQTQRSIEHFSIGSDLMPIEVIKALAIIKKAAAITNHQL
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GILARTKKEIIIKVADEIIAGELDEHFPLRVFMTGSGTQSNMNINEVISNRAIELLGGKK
EEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
GSKNPIHPNDDVNMSQSSNDTFPSAMYIATALEINNRLLPALEYMQQQLADKAKQWDDIV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHMQDAVPLTLGQEFSGYAALLENNIQRIKDTLKYVYQLALGGTAVGTGLNAPDGF
HHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCH
AEITAKYIATITSLAFVSATNKFEVQGSHDALVAVMGQLKTLANSLFKIANDIRLLSCGP
HHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RAGFHELLIPENEPGSSIMPGKVNPTQCEAMAMVAAQVIGYDVAVGIGGSAGYLEMNVYK
CCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCC
PLIIFNIIQSIKIISDSCVNFTKYLLEGMKPNHDKIEFYLKNSLMLVTALSPVIGYDKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEHHHHHHCCHHHH
KLAHYAEQKNISLAEANQELKFLSKEEFDKVVDPYKMTKGGIL
HHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MRRVETDSTGQIEVDNDKYWGAQTQRSIEHFSIGSDLMPIEVIKALAIIKKAAAITNHQL
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GILARTKKEIIIKVADEIIAGELDEHFPLRVFMTGSGTQSNMNINEVISNRAIELLGGKK
EEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
GSKNPIHPNDDVNMSQSSNDTFPSAMYIATALEINNRLLPALEYMQQQLADKAKQWDDIV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHMQDAVPLTLGQEFSGYAALLENNIQRIKDTLKYVYQLALGGTAVGTGLNAPDGF
HHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCH
AEITAKYIATITSLAFVSATNKFEVQGSHDALVAVMGQLKTLANSLFKIANDIRLLSCGP
HHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RAGFHELLIPENEPGSSIMPGKVNPTQCEAMAMVAAQVIGYDVAVGIGGSAGYLEMNVYK
CCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCC
PLIIFNIIQSIKIISDSCVNFTKYLLEGMKPNHDKIEFYLKNSLMLVTALSPVIGYDKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEHHHHHHCCHHHH
KLAHYAEQKNISLAEANQELKFLSKEEFDKVVDPYKMTKGGIL
HHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]