Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 89255577

GI number: 89255577

Start: 147103

End: 148005

Strand: Direct

Name: hemC [H]

Synonym: FTL_0140

Alternate gene names: 89255577

Gene position: 147103-148005 (Clockwise)

Preceding gene: 89255576

Following gene: 89255578

Centisome position: 7.76

GC content: 34.66

Gene sequence:

>903_bases
ATGAAACAAATAACTATAGCTAGTCGAGAAAGTAAACTAGCATTATGGCAGACAAATTTTGTCAAAAATCGTATCCAATC
AGAGCTAAACATTCCTTGTGAAATAAGTACTATGAAAACACAGGGAGATATTATTTTGGATCAACCACTAAACAAAATTG
GTGGTAAAGCACTATTTATGAAAGAGCTAGAAGTAGCAATGCTTAGTAATAAGGCTGATATTGCTGTACATTCTCTTAAA
GATGTTCCTTACCAATTACCGCAAGGTTTTTGTTTAGCAGGTTTTATGCCAAGAGAAGATCCTCGAGATGCTTTTGTATC
AAATAAATATAATTCTATTGATGATTTACCTAAAGGAGCTGTTGTTGGAACATCTAGTCTACGGCGAAAAGCGCAGCTTT
TGCACTATAGAGATGATCTTGAGATTAGAGATTTAAGAGGCAATATTCAAACTAGACTGTCTAAGCTTGATAATGGTGAT
TATGATGCGATTATTTTAGCTAGTGCTGGACTTATTCGCTTAGAGTTAGTTGAGAGAATAACTCAGTTTATCCCTGTAGA
AATATCTTTACCAGCGGTAGGTCAAGGTATAGTAGTTATAGAGGCATTAGAGAGAGATAATGACCTTTTAGAAAAAATAC
AAAAATTAAATTGTAGAGAAAGTTCTCGTGTAGCAACAGCTGAGAGAGCTTTTAATCAAGAATTAAAAGGTGGCTGTCAT
GTTGCAATAGGTGCTTATGCAGAATTAGATAATAATCAGATAACCTTGATGGCGATGGTTGCAAGTAGTGATGGTAAGAA
AATTCTCAAGCGAAAGATGATTGGGGATGATCCTACTAAACTTGGTAAATTGTTAGCTCAAGAGATGATAGCACTAGGTG
CATATAAAATATTGGAGAGTTAA

Upstream 100 bases:

>100_bases
GTTTTGCTAATGAATATAAACACTACGTAGGTATGCAGCATTCTGTATGTATGGAAGAAATAAAAGATATCTCAAACTTT
ATTGCAAAGACATTTAAAAT

Downstream 100 bases:

>100_bases
ATGGGACTTTTATTATTATTGGTAGGTATTGGTGGTGGTTTTGGTGCAATGGCAAGATTTGCATTGACTCAAGCAACCGC
AAGTATTTCTAAGCAAATTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES

Sequences:

>Translated_300_residues
MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
>Mature_300_residues
MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=278, Percent_Identity=41.726618705036, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI66933009, Length=278, Percent_Identity=41.726618705036, Blast_Score=194, Evalue=7e-50,
Organism=Escherichia coli, GI48994974, Length=298, Percent_Identity=55.0335570469799, Blast_Score=310, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6319996, Length=314, Percent_Identity=40.4458598726115, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20130425, Length=279, Percent_Identity=41.9354838709677, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33307; Mature: 33307

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFM
CCCEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHCCCEEHH
KELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGA
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCC
VVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERI
EECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
TQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
HHHCCEEEECCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
EEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFM
CCCEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHCCCEEHH
KELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGA
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCC
VVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERI
EECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
TQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
HHHCCEEEECCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
EEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA