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The map label for this gene is estA [H]

Identifier: 89255576

GI number: 89255576

Start: 146438

End: 147106

Strand: Direct

Name: estA [H]

Synonym: FTL_0139

Alternate gene names: 89255576

Gene position: 146438-147106 (Clockwise)

Preceding gene: 89255575

Following gene: 89255577

Centisome position: 7.72

GC content: 33.18

Gene sequence:

>669_bases
ATGAATTACGAACTTATGGAGCCAGCAAAGCAGGCTAAGTTTTGTGTTATATGGCTGCATGGCCTTGGTGCTGATGGACA
TGATTTTGTAGATATTGTTAACTATTTTGATGTTTCATTGGATGAAATCAGATTTATTTTTCCTCATGCTGATATTATAC
CTGTGACTATAAACATGGGGATGCAGATGCGTGCTTGGTATGATATCAAGTCACTTGATGCAAATAGCCTAAATAGAGTA
GTTGATGTTGAAGGTATAAATAGTTCAATAGCAAAAGTTAATAAATTAATAGATAGTCAAGTCAATCAAGGTATTGCTAG
TGAAAATATTATCTTAGCGGGTTTTTCACAAGGTGGTGTAATTGCTACCTATACGGCTATTACATCTCAAATGAAGCTTG
GTGGTATTATGGCTTTATCTACATATTTGCCAGCATGGGATAATTTTAAAGGTAAAATTACATCTATAAATAAAGGATTA
CCTATACTAGTTTGCCATGGTACGGATGATCAGGTATTACCTGAAGTTCTTGGTCATGATTTATCAGATAAACTAAAAGT
TAGCGGTTTTGCTAATGAATATAAACACTACGTAGGTATGCAGCATTCTGTATGTATGGAAGAAATAAAAGATATCTCAA
ACTTTATTGCAAAGACATTTAAAATATGA

Upstream 100 bases:

>100_bases
TAGAGTACAATGCTTTCGGAGGTGTTTAAATTTTTAGATATTAATAAATTTCTTAAACTAATGTATCATTCTACCTAATA
TTAGTAGATTTAGAAATTTT

Downstream 100 bases:

>100_bases
AACAAATAACTATAGCTAGTCGAGAAAGTAAACTAGCATTATGGCAGACAAATTTTGTCAAAAATCGTATCCAATCAGAG
CTAAACATTCCTTGTGAAAT

Product: carboxylesterase/phospholipase family protein

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNYELMEPAKQAKFCVIWLHGLGADGHDFVDIVNYFDVSLDEIRFIFPHADIIPVTINMGMQMRAWYDIKSLDANSLNRV
VDVEGINSSIAKVNKLIDSQVNQGIASENIILAGFSQGGVIATYTAITSQMKLGGIMALSTYLPAWDNFKGKITSINKGL
PILVCHGTDDQVLPEVLGHDLSDKLKVSGFANEYKHYVGMQHSVCMEEIKDISNFIAKTFKI

Sequences:

>Translated_222_residues
MNYELMEPAKQAKFCVIWLHGLGADGHDFVDIVNYFDVSLDEIRFIFPHADIIPVTINMGMQMRAWYDIKSLDANSLNRV
VDVEGINSSIAKVNKLIDSQVNQGIASENIILAGFSQGGVIATYTAITSQMKLGGIMALSTYLPAWDNFKGKITSINKGL
PILVCHGTDDQVLPEVLGHDLSDKLKVSGFANEYKHYVGMQHSVCMEEIKDISNFIAKTFKI
>Mature_222_residues
MNYELMEPAKQAKFCVIWLHGLGADGHDFVDIVNYFDVSLDEIRFIFPHADIIPVTINMGMQMRAWYDIKSLDANSLNRV
VDVEGINSSIAKVNKLIDSQVNQGIASENIILAGFSQGGVIATYTAITSQMKLGGIMALSTYLPAWDNFKGKITSINKGL
PILVCHGTDDQVLPEVLGHDLSDKLKVSGFANEYKHYVGMQHSVCMEEIKDISNFIAKTFKI

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI5453722, Length=213, Percent_Identity=40.8450704225352, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI9966764, Length=212, Percent_Identity=36.3207547169811, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI20270341, Length=209, Percent_Identity=25.3588516746411, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508057, Length=216, Percent_Identity=39.3518518518519, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323147, Length=223, Percent_Identity=34.0807174887892, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45553055, Length=206, Percent_Identity=35.4368932038835, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45553057, Length=206, Percent_Identity=35.4368932038835, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357257, Length=206, Percent_Identity=35.4368932038835, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161078179, Length=211, Percent_Identity=26.0663507109005, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 24603; Mature: 24603

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYELMEPAKQAKFCVIWLHGLGADGHDFVDIVNYFDVSLDEIRFIFPHADIIPVTINMG
CCCCCCCHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHEEEEECCCCEEEEEECCC
MQMRAWYDIKSLDANSLNRVVDVEGINSSIAKVNKLIDSQVNQGIASENIILAGFSQGGV
CEEEEEECHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCE
IATYTAITSQMKLGGIMALSTYLPAWDNFKGKITSINKGLPILVCHGTDDQVLPEVLGHD
EEEHHHHHHHHHHCHHEEHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCC
LSDKLKVSGFANEYKHYVGMQHSVCMEEIKDISNFIAKTFKI
CCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYELMEPAKQAKFCVIWLHGLGADGHDFVDIVNYFDVSLDEIRFIFPHADIIPVTINMG
CCCCCCCHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHEEEEECCCCEEEEEECCC
MQMRAWYDIKSLDANSLNRVVDVEGINSSIAKVNKLIDSQVNQGIASENIILAGFSQGGV
CEEEEEECHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCE
IATYTAITSQMKLGGIMALSTYLPAWDNFKGKITSINKGLPILVCHGTDDQVLPEVLGHD
EEEHHHHHHHHHHCHHEEHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCC
LSDKLKVSGFANEYKHYVGMQHSVCMEEIKDISNFIAKTFKI
CCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA